Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2

October 24th, 2016 by Xiaozhe Xiong

Nature Chemical Biology 12, 1111 (2016). doi:10.1038/nchembio.2218

Authors: Xiaozhe Xiong, Tatyana Panchenko, Shuang Yang, Shuai Zhao, Peiqiang Yan, Wenhao Zhang, Wei Xie, Yuanyuan Li, Yingming Zhao, C David Allis & Haitao Li

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Design and characterization of bivalent BET inhibitors

October 24th, 2016 by Minoru Tanaka

Nature Chemical Biology 12, 1089 (2016). doi:10.1038/nchembio.2209

Authors: Minoru Tanaka, Justin M Roberts, Hyuk-Soo Seo, Amanda Souza, Joshiawa Paulk, Thomas G Scott, Stephen L DeAngelo, Sirano Dhe-Paganon & James E Bradner

Synthetic biology: Cholera detectors

October 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2222

Author: Caitlin Deane

Proteomics: Fishing for zinc

October 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2220

Author: Grant Miura

Protein dynamics: Conformational footprints

October 18th, 2016 by Buyong Ma

Nature Chemical Biology 12, 890 (2016). doi:10.1038/nchembio.2212

Authors: Buyong Ma & Ruth Nussinov

The mechanisms by which proteins evolve new functions can be slow and mysterious. Comprehensive structural analysis of enzyme variants reveal how gradual enrichments of pre-existing populations with the right productive dynamics for new functions can accomplish this aim.

Insulin signaling: At a snail’s pace

October 18th, 2016 by Stéphane Larochelle

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2221

Author: Stéphane Larochelle

Long non-coding RNAs: Pulsating RNA motifs

October 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2223

Author: Terry L. Sheppard

Antibiotics: New recipe for targeting resistance

October 18th, 2016 by Balázs Papp

Nature Chemical Biology 12, 891 (2016). doi:10.1038/nchembio.2215

Authors: Balázs Papp & Viktória Lázár

The rapid spread of antibiotic-resistant bacteria demands novel treatment approaches that delay or even reverse the evolution of resistance. A new screening strategy identifies two compounds that select against a common tetracycline-resistance gene in Escherichia coli.

Enzyme mechanisms: Sugary shears

October 18th, 2016 by Ethan D Goddard-Borger

Nature Chemical Biology 12, 892 (2016). doi:10.1038/nchembio.2216

Author: Ethan D Goddard-Borger

Proteolytic maturation of an important transcriptional regulator is performed by a glycosyltransferase. The reaction involves glycosylation of a glutamate residue and conversion of the γ-glycosyl ester product into an N-acyl pyroglutamate, which undergoes spontaneous hydrolysis to effect peptide backbone fission.

Metabolic engineering: Biosensors get the green light

October 18th, 2016 by Sarah K Hammer

Nature Chemical Biology 12, 894 (2016). doi:10.1038/nchembio.2214

Authors: Sarah K Hammer & José L Avalos

A novel approach recruits the largest prokaryotic family of ligand-induced transcriptional regulators to develop a new class of biosensors in yeast based on transcriptional activation, vastly expanding the repertoire of biosensors that could function in eukaryotic hosts.