Ion channels: Calcium channels work together

June 17th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 467 (2016). doi:10.1038/nchembio.2123

Author: Mirella Bucci

Chemical genetics: Unraveling cell death mysteries

June 17th, 2016 by Xiomaris M Cotto-Rios

Nature Chemical Biology 12, 470 (2016). doi:10.1038/nchembio.2110

Authors: Xiomaris M Cotto-Rios & Evripidis Gavathiotis

Non-apoptotic regulated cell death is not fully characterized, particularly for ferroptosis, the iron- and ROS-dependent form of regulated cell death. A systematic approach using modulatory profiling and cell line sensitivity analysis has unraveled the association of lipid metabolism with ferroptosis and enabled the discovery of a novel specific ferroptosis inducer.

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast

June 13th, 2016 by François Collard

Nature Chemical Biology 12, 601 (2016). doi:10.1038/nchembio.2104

Authors: François Collard, Francesca Baldin, Isabelle Gerin, Jennifer Bolsée, Gaëtane Noël, Julie Graff, Maria Veiga-da-Cunha, Vincent Stroobant, Didier Vertommen, Amina Houddane, Mark H Rider, Carole L Linster, Emile Van Schaftingen & Guido T Bommer

  • Posted in Nat Chem Biol, Publications
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Fluorescence probes to detect lipid-derived radicals

June 13th, 2016 by Ken-ichi Yamada

Nature Chemical Biology 12, 608 (2016). doi:10.1038/nchembio.2105

Authors: Ken-ichi Yamada, Fumiya Mito, Yuta Matsuoka, Satsuki Ide, Kazushige Shikimachi, Ayano Fujiki, Daiki Kusakabe, Yuma Ishida, Masataka Enoki, Arisa Tada, Miyuki Ariyoshi, Toshihide Yamasaki & Mayumi Yamato

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

June 13th, 2016 by Pu-Hyeon Cha

Nature Chemical Biology 12, 593 (2016). doi:10.1038/nchembio.2103

Authors: Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han & Kang-Yell Choi

  • Posted in Nat Chem Biol, Publications
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Real-time intravital imaging of pH variation associated with osteoclast activity

June 6th, 2016 by Hiroki Maeda

Nature Chemical Biology 12, 579 (2016). doi:10.1038/nchembio.2096

Authors: Hiroki Maeda, Toshiyuki Kowada, Junichi Kikuta, Masayuki Furuya, Mai Shirazaki, Shin Mizukami, Masaru Ishii & Kazuya Kikuchi

  • Posted in Nat Chem Biol, Publications
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Copper regulates cyclic-AMP-dependent lipolysis

June 6th, 2016 by Lakshmi Krishnamoorthy

Nature Chemical Biology 12, 586 (2016). doi:10.1038/nchembio.2098

Authors: Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko & Christopher J Chang

Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes

May 30th, 2016 by Simon Wisnovsky

Nature Chemical Biology 12, 567 (2016). doi:10.1038/nchembio.2102

Authors: Simon Wisnovsky, Sae Rin Jean & Shana O Kelley

  • Posted in Nat Chem Biol, Publications
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Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

May 30th, 2016 by Giancarlo Bruni

Nature Chemical Biology 12, 559 (2016). doi:10.1038/nchembio.2097

Authors: Giancarlo Bruni, Andrew J Rennekamp, Andrea Velenich, Matthew McCarroll, Leo Gendelev, Ethan Fertsch, Jack Taylor, Parth Lakhani, Dennis Lensen, Tama Evron, Paul J Lorello, Xi-Ping Huang, Sabine Kolczewski, Galen Carey, Barbara J Caldarone, Eric Prinssen, Bryan L Roth, Michael J Keiser, Randall T Peterson & David Kokel

  • Posted in Nat Chem Biol, Publications
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σ1 receptor ligands control a switch between passive and active threat responses

May 30th, 2016 by Andrew J Rennekamp

Nature Chemical Biology 12, 552 (2016). doi:10.1038/nchembio.2089

Authors: Andrew J Rennekamp, Xi-Ping Huang, You Wang, Samir Patel, Paul J Lorello, Lindsay Cade, Andrew P W Gonzales, Jing-Ruey Joanna Yeh, Barbara J Caldarone, Bryan L Roth, David Kokel & Randall T Peterson

  • Posted in Nat Chem Biol, Publications
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