Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

November 28th, 2016 by Hans Michael Maric

Nature Chemical Biology 13, 153 (2017). doi:10.1038/nchembio.2246

Authors: Hans Michael Maric, Torben Johann Hausrat, Franziska Neubert, Nils Ole Dalby, Sören Doose, Markus Sauer, Matthias Kneussel & Kristian Strømgaard

  • Posted in Nat Chem Biol, Publications
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Full antagonism of the estrogen receptor without a prototypical ligand side chain

November 21st, 2016 by Sathish Srinivasan

Nature Chemical Biology 13, 111 (2017). doi:10.1038/nchembio.2236

Authors: Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen & Kendall W Nettles

  • Posted in Nat Chem Biol, Publications
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The RNA helicase Mtr4p is a duplex-sensing translocase

November 21st, 2016 by Eric M Patrick

Nature Chemical Biology 13, 99 (2017). doi:10.1038/nchembio.2234

Authors: Eric M Patrick, Sukanya Srinivasan, Eckhard Jankowsky & Matthew J Comstock

A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

November 21st, 2016 by John C Rose

Nature Chemical Biology 13, 119 (2017). doi:10.1038/nchembio.2244

Authors: John C Rose, Po-Ssu Huang, Nathan D Camp, Jordan Ye, Andrew M Leidal, Inna Goreshnik, Bridget M Trevillian, Miles S Dickinson, Daniel Cunningham-Bryant, Jayanta Debnath, David Baker, Alejandro Wolf-Yadlin & Dustin J Maly

  • Posted in Nat Chem Biol, Publications
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Ubiquitin utilizes an acidic surface patch to alter chromatin structure

November 21st, 2016 by Galia T Debelouchina

Nature Chemical Biology 13, 105 (2017). doi:10.1038/nchembio.2235

Authors: Galia T Debelouchina, Karola Gerecht & Tom W Muir

  • Posted in Nat Chem Biol, Publications
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Nuclear receptors: PPARα ligands make memories

November 15th, 2016 by Thomas P Burris

Nature Chemical Biology 12, 993 (2016). doi:10.1038/nchembio.2241

Author: Thomas P Burris

Three newly identified endogenous ligands of the nuclear receptor PPARα—hydroxydimethylbutyrate, hexadecanamide and octadecenamide—are implicated in the noncanonical activity of PPARα in synaptic function and hippocampal plasticity.

Photosynthesis: Short circuit at the chlorophyll

November 15th, 2016 by Marc M Nowaczyk

Nature Chemical Biology 12, 990 (2016). doi:10.1038/nchembio.2240

Authors: Marc M Nowaczyk & Nicolas Plumeré

Interfacing photosynthetic proteins and electrodes for investigating light-induced charge separation remains challenging. The discovery of a competing charge transfer pathway through the light-harvesting antenna defines new design requirements for electrode modification.

Immunology: T cells get L-ARGed

November 15th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2256

Author: Mirella Bucci

Protein synthesis: Breaking down the NSA1

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2258

Author: Grant Miura

Epigenomics: Massive ATAC

November 15th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2257

Author: Joshua M. Finkelstein