Bioconjugation: Methionine’s time to shine

March 22nd, 2017 by Caitlin Deane

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2350

Author: Caitlin Deane

Imaging: Luciferase matchmaker

March 22nd, 2017 by Caitlin Deane

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2352

Author: Caitlin Deane

Versatile modes of cellular regulation via cyclic dinucleotides

March 22nd, 2017 by Petya Violinova Krasteva

Nature Chemical Biology 13, 350 (2017). doi:10.1038/nchembio.2337

Authors: Petya Violinova Krasteva & Holger Sondermann

Signaling: Spatial regulation of axonal cAMP

March 22nd, 2017 by Pierre Vincent

Nature Chemical Biology 13, 348 (2017). doi:10.1038/nchembio.2339

Authors: Pierre Vincent & Liliana R Castro

In early-stage developing neurons, the cAMP–PKA (protein kinase A) signaling pathway is strongly inhibited. This negative control is later removed, unleashing cAMP–PKA signaling, particularly in distal axonal parts, thus allowing for axonal growth.

Protein folding: Illuminating chaperone activity

March 22nd, 2017 by Danny M Hatters

Nature Chemical Biology 13, 346 (2017). doi:10.1038/nchembio.2332

Author: Danny M Hatters

Pharmacological chaperones are small drugs that stabilize a protein's fold and are being developed to treat diseases arising from protein misfolding. A mathematical framework to model their activity in cells enables insight into their mechanism and capacity to rescue protein foldedness.

A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

March 20th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 551 (2017). doi:10.1038/nchembio.2336

Authors: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis

March 20th, 2017 by Marta C Marques

Nature Chemical Biology 13, 544 (2017). doi:10.1038/nchembio.2335

Authors: Marta C Marques, Cristina Tapia, Oscar Gutiérrez-Sanz, Ana Raquel Ramos, Kimberly L Keller, Judy D Wall, Antonio L De Lacey, Pedro M Matias & Inês A C Pereira

  • Posted in Nat Chem Biol, Publications
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Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges

March 20th, 2017 by Vinayak Agarwal

Nature Chemical Biology 13, 537 (2017). doi:10.1038/nchembio.2330

Authors: Vinayak Agarwal, Jessica M Blanton, Sheila Podell, Arnaud Taton, Michelle A Schorn, Julia Busch, Zhenjian Lin, Eric W Schmidt, Paul R Jensen, Valerie J Paul, Jason S Biggs, James W Golden, Eric E Allen & Bradley S Moore

  • Posted in Nat Chem Biol, Publications
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The Rrp4–exosome complex recruits and channels substrate RNA by a unique mechanism

March 13th, 2017 by Milos A Cvetkovic

Nature Chemical Biology 13, 522 (2017). doi:10.1038/nchembio.2328

Authors: Milos A Cvetkovic, Jan Philip Wurm, Maxime J Audin, Stefan Schütz & Remco Sprangers

  • Posted in Nat Chem Biol, Publications
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In silico design of novel probes for the atypical opioid receptor MRGPRX2

March 13th, 2017 by Katherine Lansu

Nature Chemical Biology 13, 529 (2017). doi:10.1038/nchembio.2334

Authors: Katherine Lansu, Joel Karpiak, Jing Liu, Xi-Ping Huang, John D McCorvy, Wesley K Kroeze, Tao Che, Hiroshi Nagase, Frank I Carroll, Jian Jin, Brian K Shoichet & Bryan L Roth

  • Posted in Nat Chem Biol, Publications
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