Epigenomics: Massive ATAC

November 15th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2257

Author: Joshua M. Finkelstein

Drug discovery: Doubling down on BET inhibition

November 15th, 2016 by Dafydd Owen

Nature Chemical Biology 12, 991 (2016). doi:10.1038/nchembio.2242

Author: Dafydd Owen

Through simultaneous binding to more than one site in a single protein, multivalent small molecules can achieve huge increases in potency. This 'avidity effect' has been demonstrated in BET bromodomain-containing proteins with bivalent probes that represent some of the most potent BET inhibitors to date.

RNA structure: Know when to fold ’em

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2255

Author: Grant Miura

Nuclear receptors: PPARα ligands make memories

November 15th, 2016 by Thomas P Burris

Nature Chemical Biology 12, 993 (2016). doi:10.1038/nchembio.2241

Author: Thomas P Burris

Three newly identified endogenous ligands of the nuclear receptor PPARα—hydroxydimethylbutyrate, hexadecanamide and octadecenamide—are implicated in the noncanonical activity of PPARα in synaptic function and hippocampal plasticity.

Ferroptosis: Oxidized PEs trigger death

November 14th, 2016 by Katharina D'Herde

Nature Chemical Biology 13, 4 (2017). doi:10.1038/nchembio.2261

Authors: Katharina D'Herde & Dmitri V Krysko

Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

November 14th, 2016 by Sebastian Doll

Nature Chemical Biology 13, 91 (2017). doi:10.1038/nchembio.2239

Authors: Sebastian Doll, Bettina Proneth, Yulia Y Tyurina, Elena Panzilius, Sho Kobayashi, Irina Ingold, Martin Irmler, Johannes Beckers, Michaela Aichler, Axel Walch, Holger Prokisch, Dietrich Trümbach, Gaowei Mao, Feng Qu, Hulya Bayir, Joachim Füllekrug, Christina H Scheel, Wolfgang Wurst, Joel A Schick, Valerian E Kagan, José Pedro Friedmann Angeli & Marcus Conrad

  • Posted in Nat Chem Biol, Publications
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Tunable thermal bioswitches for in vivo control of microbial therapeutics

November 14th, 2016 by Dan I Piraner

Nature Chemical Biology 13, 75 (2017). doi:10.1038/nchembio.2233

Authors: Dan I Piraner, Mohamad H Abedi, Brittany A Moser, Audrey Lee-Gosselin & Mikhail G Shapiro

  • Posted in Nat Chem Biol, Publications
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

November 14th, 2016 by Valerian E Kagan

Nature Chemical Biology 13, 81 (2017). doi:10.1038/nchembio.2238

Authors: Valerian E Kagan, Gaowei Mao, Feng Qu, Jose Pedro Friedmann Angeli, Sebastian Doll, Claudette St Croix, Haider Hussain Dar, Bing Liu, Vladimir A Tyurin, Vladimir B Ritov, Alexandr A Kapralov, Andrew A Amoscato, Jianfei Jiang, Tamil Anthonymuthu, Dariush Mohammadyani, Qin Yang, Bettina Proneth, Judith Klein-Seetharaman, Simon Watkins, Ivet Bahar, Joel Greenberger, Rama K Mallampalli, Brent R Stockwell, Yulia Y Tyurina, Marcus Conrad & Hülya Bayır

Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

November 14th, 2016 by Ryan S Nett

Nature Chemical Biology 13, 69 (2017). doi:10.1038/nchembio.2232

Authors: Ryan S Nett, Mariana Montanares, Ariana Marcassa, Xuan Lu, Raimund Nagel, Trevor C Charles, Peter Hedden, Maria Cecilia Rojas & Reuben J Peters

  • Posted in Nat Chem Biol, Publications
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Non-classical transpeptidases yield insight into new antibacterials

November 7th, 2016 by Pankaj Kumar

Nature Chemical Biology 13, 54 (2017). doi:10.1038/nchembio.2237

Authors: Pankaj Kumar, Amit Kaushik, Evan P Lloyd, Shao-Gang Li, Rohini Mattoo, Nicole C Ammerman, Drew T Bell, Alexander L Perryman, Trevor A Zandi, Sean Ekins, Stephan L Ginell, Craig A Townsend, Joel S Freundlich & Gyanu Lamichhane