Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

August 21st, 2017 by Marie Pancera

Nature Chemical Biology 13, 1115 (2017). doi:10.1038/nchembio.2460

Authors: Marie Pancera, Yen-Ting Lai, Tatsiana Bylund, Aliaksandr Druz, Sandeep Narpala, Sijy O'Dell, Arne Schön, Robert T Bailer, Gwo-Yu Chuang, Hui Geng, Mark K Louder, Reda Rawi, Djade I Soumana, Andrés Finzi, Alon Herschhorn, Navid Madani, Joseph Sodroski, Ernesto Freire, David R Langley, John R Mascola, Adrian B McDermott & Peter D Kwong

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Protein engineering: Redirecting membrane machinery

August 18th, 2017 by Kalistyn Burley

Nature Chemical Biology 13, 927 (2017). doi:10.1038/nchembio.2451

Authors: Kalistyn Burley & Celia W Goulding

The ability to solubilize membrane proteins while retaining their native function is a persistent challenge. Re-engineering of the membrane protein DsbB into a soluble cytoplasmic version maintained its activity and enabled recompartmentalization of the periplasmic DsbAB disulfide bond–forming system.

Extracellular vesicles: Taking metabolism on the road

August 18th, 2017 by Lucas B Sullivan

Nature Chemical Biology 13, 924 (2017). doi:10.1038/nchembio.2455

Author: Lucas B Sullivan

Extracellular vesicles (EVs) are a class of secreted membrane particles capable of transferring biological molecules between cells. Metabolomics measurements indicate that isolated EVs also have autonomous metabolic enzyme activities, including the unexpected identification of endogenous human asparaginase activity.

Protein design: I like to fold it, fold it

August 18th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2467

Author: Caitlin Deane

Neurobiology: Lighting up neurons

August 18th, 2017 by Grant Miura

Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2469

Author: Grant Miura

Bacterial immunity: A virtuous CRISPR cycle

August 18th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2468

Author: Terry L. Sheppard

Drug development: Locking down metabolism

August 18th, 2017 by William R Bishai

Nature Chemical Biology 13, 925 (2017). doi:10.1038/nchembio.2452

Author: William R Bishai

An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase—an enzyme that is nonessential for in vitro growth—has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.

A kinetic view of GPCR allostery and biased agonism

August 18th, 2017 by J Robert Lane

Nature Chemical Biology 13, 929 (2017). doi:10.1038/nchembio.2431

Authors: J Robert Lane, Lauren T May, Robert G Parton, Patrick M Sexton & Arthur Christopoulos

Ubiquitin-proteasome system: Rescuing EBV latency

August 18th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2466

Author: Mirella Bucci

Kinetochore regulation: Let there be light

August 14th, 2017 by Ana C Figueiredo

Nature Chemical Biology 13, 1058 (2017). doi:10.1038/nchembio.2464

Authors: Ana C Figueiredo & Helder Maiato

Kinetochores form the critical interface with spindle microtubules that accounts for chromosome movement and segregation fidelity during mitosis. Spatial and temporal control of motor protein and checkpoint signaling at kinetochores is now possible with a new set of optogenetic tools.