Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

January 21st, 2019 by Ruobo Zhou

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic, Published online: 21 January 2019; doi:10.1038/s41589-018-0209-y

Single-molecule analysis reveals a novel binding state of Holliday junction (HJ) resolving enzymes where the enzymes partially dissociate from the HJ and allowing nearly unencumbered HJ dynamics, suggesting coupled branch migration and HJ resolution.
  • Posted in Nat Chem Biol, Publications
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Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

January 21st, 2019 by Xiaoxue Zhou

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum, Published online: 21 January 2019; doi:10.1038/s41589-018-0206-1

Assembly of the mycobacterial cell envelope layers, including peptidoglycan (PG) and the mycomembrane (MM), is synchronous during elongation, when a mobile fraction of the MM diffuses into the septum after thinning of the diffusion barrier formed by PG.
  • Posted in Nat Chem Biol, Publications
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Pass it along

January 18th, 2019 by Yiyun Song

Pass it along

Pass it along, Published online: 18 January 2019; doi:10.1038/s41589-018-0221-2

Pass it along

Cutting in choline

January 18th, 2019 by Caitlin Deane

Cutting in choline

Cutting in choline, Published online: 18 January 2019; doi:10.1038/s41589-018-0218-x

Cutting in choline

Ras tuning

January 18th, 2019 by Grant Miura

Ras tuning

Ras tuning, Published online: 18 January 2019; doi:10.1038/s41589-018-0219-9

Ras tuning

Molecular tools for imaging and recording neuronal activity

January 18th, 2019 by Wenjing Wang

Molecular tools for imaging and recording neuronal activity

Molecular tools for imaging and recording neuronal activity, Published online: 18 January 2019; doi:10.1038/s41589-018-0207-0

A collection of genetically encoded tools, each with their own capabilities, limitations and performance characteristics, are available for monitoring and manipulating neuronal activity that could allow visualizing the brain at single-cell resolution.

A new Tar-get for inhibition

January 18th, 2019 by Mirella Bucci

A new Tar-get for inhibition

A new Tar-get for inhibition, Published online: 18 January 2019; doi:10.1038/s41589-018-0220-3

A new Tar-get for inhibition

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

January 14th, 2019 by Jennifer S. Spence

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

IFITM3 directly engages and shuttles incoming virus particles to lysosomes, Published online: 14 January 2019; doi:10.1038/s41589-018-0213-2

Live-cell imaging and virus trafficking studies show that the host innate immune receptor IFITM3 localizes with endocytic vesicles that fuse with incoming viruses to ultimately enhance their traffic to lysosomes.
  • Posted in Nat Chem Biol, Publications
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Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

January 14th, 2019 by Naoya Shindo

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Published online: 14 January 2019; doi:10.1038/s41589-018-0204-3

Discovery and exploitation of inherent reaction features of chlorofluoroacetamide (CFA) as a warhead such as low off-target activity and reversible reactivity with cysteine enable specific covalent inhibition of targeted kinases.
  • Posted in Nat Chem Biol, Publications
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Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

January 14th, 2019 by Yeon Hee Ban

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis, Published online: 14 January 2019; doi:10.1038/s41589-018-0203-4

The reconstitution of gentamicin B biosynthesis reveals the existence of multiple new intermediates and branching pathways and enables the identification of factors that contribute to the low levels of the natural product in the native producer.
  • Posted in Nat Chem Biol, Publications
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