Metabolic engineering: Biosensors get the green light

October 18th, 2016 by Sarah K Hammer

Nature Chemical Biology 12, 894 (2016). doi:10.1038/nchembio.2214

Authors: Sarah K Hammer & José L Avalos

A novel approach recruits the largest prokaryotic family of ligand-induced transcriptional regulators to develop a new class of biosensors in yeast based on transcriptional activation, vastly expanding the repertoire of biosensors that could function in eukaryotic hosts.

Synthetic biology: Cholera detectors

October 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2222

Author: Caitlin Deane

Proteomics: Fishing for zinc

October 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2220

Author: Grant Miura

Protein dynamics: Conformational footprints

October 18th, 2016 by Buyong Ma

Nature Chemical Biology 12, 890 (2016). doi:10.1038/nchembio.2212

Authors: Buyong Ma & Ruth Nussinov

The mechanisms by which proteins evolve new functions can be slow and mysterious. Comprehensive structural analysis of enzyme variants reveal how gradual enrichments of pre-existing populations with the right productive dynamics for new functions can accomplish this aim.

Insulin signaling: At a snail’s pace

October 18th, 2016 by Stéphane Larochelle

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2221

Author: Stéphane Larochelle

Long non-coding RNAs: Pulsating RNA motifs

October 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 889 (2016). doi:10.1038/nchembio.2223

Author: Terry L. Sheppard

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

October 17th, 2016 by John Chu

Nature Chemical Biology 12, 1004 (2016). doi:10.1038/nchembio.2207

Authors: John Chu, Xavier Vila-Farres, Daigo Inoyama, Melinda Ternei, Louis J Cohen, Emma A Gordon, Boojala Vijay B Reddy, Zachary Charlop-Powers, Henry A Zebroski, Ricardo Gallardo-Macias, Mark Jaskowski, Shruthi Satish, Steven Park, David S Perlin, Joel S Freundlich & Sean F Brady

Here we present a natural product discovery approach, whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial culture and gene expression. When we applied the approach to nonribosomal peptide synthetase gene clusters from human-associated bacteria, we identified the humimycins. These antibiotics inhibit lipid II flippase and potentiate β-lactam activity against methicillin-resistant Staphylococcus aureus in mice, potentially providing a new treatment regimen.

  • Posted in Nat Chem Biol, Publications
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Identification and characterization of PPARα ligands in the hippocampus

October 17th, 2016 by Avik Roy

Nature Chemical Biology 12, 1075 (2016). doi:10.1038/nchembio.2204

Authors: Avik Roy, Madhuchhanda Kundu, Malabendu Jana, Rama K Mishra, Yeni Yung, Chi-Hao Luan, Frank J Gonzalez & Kalipada Pahan

  • Posted in Nat Chem Biol, Publications
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A prevalent intraresidue hydrogen bond stabilizes proteins

October 17th, 2016 by Robert W Newberry

Nature Chemical Biology 12, 1084 (2016). doi:10.1038/nchembio.2206

Authors: Robert W Newberry & Ronald T Raines

Structural and conformational determinants of macrocycle cell permeability

October 17th, 2016 by Björn Over

Nature Chemical Biology 12, 1065 (2016). doi:10.1038/nchembio.2203

Authors: Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall & Jan Kihlberg

  • Posted in Nat Chem Biol, Publications
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