A human microprotein that interacts with the mRNA decapping complex

December 5th, 2016 by Nadia G D'Lima

Nature Chemical Biology 13, 174 (2017). doi:10.1038/nchembio.2249

Authors: Nadia G D'Lima, Jiao Ma, Lauren Winkler, Qian Chu, Ken H Loh, Elizabeth O Corpuz, Bogdan A Budnik, Jens Lykke-Andersen, Alan Saghatelian & Sarah A Slavoff

Quantitating drug-target engagement in single cells in vitro and in vivo

December 5th, 2016 by J Matthew Dubach

Nature Chemical Biology 13, 168 (2017). doi:10.1038/nchembio.2248

Authors: J Matthew Dubach, Eunha Kim, Katherine Yang, Michael Cuccarese, Randy J Giedt, Labros G Meimetis, Claudio Vinegoni & Ralph Weissleder

  • Posted in Nat Chem Biol, Publications
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Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine

December 5th, 2016 by Monica Yun Liu

Nature Chemical Biology 13, 181 (2017). doi:10.1038/nchembio.2250

Authors: Monica Yun Liu, Hedieh Torabifard, Daniel J Crawford, Jamie E DeNizio, Xing-Jun Cao, Benjamin A Garcia, G Andrés Cisneros & Rahul M Kohli

  • Posted in Nat Chem Biol, Publications
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Activation and reduction of carbon dioxide by nitrogenase iron proteins

November 28th, 2016 by Johannes G Rebelein

Nature Chemical Biology 13, 147 (2017). doi:10.1038/nchembio.2245

Authors: Johannes G Rebelein, Martin T Stiebritz, Chi Chung Lee & Yilin Hu

The iron (Fe) proteins of molybdenum (Mo) and vanadium (V) nitrogenases mimic carbon monoxide (CO) dehydrogenase in catalyzing the interconversion between CO2 and CO under ambient conditions. Catalytic reduction of CO2 to CO is achieved in vitro and in vivo upon redox changes of the Fe-protein-associated [Fe4S4] clusters. These observations establish the Fe protein as a model for investigation of CO2 activation while suggesting its biotechnological adaptability for recycling the greenhouse gas into useful products.

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Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

November 28th, 2016 by Hans Michael Maric

Nature Chemical Biology 13, 153 (2017). doi:10.1038/nchembio.2246

Authors: Hans Michael Maric, Torben Johann Hausrat, Franziska Neubert, Nils Ole Dalby, Sören Doose, Markus Sauer, Matthias Kneussel & Kristian Strømgaard

  • Posted in Nat Chem Biol, Publications
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Full antagonism of the estrogen receptor without a prototypical ligand side chain

November 21st, 2016 by Sathish Srinivasan

Nature Chemical Biology 13, 111 (2017). doi:10.1038/nchembio.2236

Authors: Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen & Kendall W Nettles

  • Posted in Nat Chem Biol, Publications
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The RNA helicase Mtr4p is a duplex-sensing translocase

November 21st, 2016 by Eric M Patrick

Nature Chemical Biology 13, 99 (2017). doi:10.1038/nchembio.2234

Authors: Eric M Patrick, Sukanya Srinivasan, Eckhard Jankowsky & Matthew J Comstock

A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

November 21st, 2016 by John C Rose

Nature Chemical Biology 13, 119 (2017). doi:10.1038/nchembio.2244

Authors: John C Rose, Po-Ssu Huang, Nathan D Camp, Jordan Ye, Andrew M Leidal, Inna Goreshnik, Bridget M Trevillian, Miles S Dickinson, Daniel Cunningham-Bryant, Jayanta Debnath, David Baker, Alejandro Wolf-Yadlin & Dustin J Maly

  • Posted in Nat Chem Biol, Publications
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Ubiquitin utilizes an acidic surface patch to alter chromatin structure

November 21st, 2016 by Galia T Debelouchina

Nature Chemical Biology 13, 105 (2017). doi:10.1038/nchembio.2235

Authors: Galia T Debelouchina, Karola Gerecht & Tom W Muir

  • Posted in Nat Chem Biol, Publications
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Nuclear receptors: PPARα ligands make memories

November 15th, 2016 by Thomas P Burris

Nature Chemical Biology 12, 993 (2016). doi:10.1038/nchembio.2241

Author: Thomas P Burris

Three newly identified endogenous ligands of the nuclear receptor PPARα—hydroxydimethylbutyrate, hexadecanamide and octadecenamide—are implicated in the noncanonical activity of PPARα in synaptic function and hippocampal plasticity.