Structural biology: HDAC6 finally crystal clear

August 18th, 2016 by Yanli Liu

Nature Chemical Biology 12, 660 (2016). doi:10.1038/nchembio.2158

Authors: Yanli Liu, Li Li & Jinrong Min

Crystal structures of both catalytic domains of HDAC6 provide insights into the mechanisms of deacetylation for their specific substrates and a structural basis for understanding selective inhibition of HDAC6.

Plant biology: Shoot for the top

August 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2161

Author: Grant Miura

Insights into newly discovered marks and readers of epigenetic information

August 18th, 2016 by Forest H Andrews

Nature Chemical Biology 12, 662 (2016). doi:10.1038/nchembio.2149

Authors: Forest H Andrews, Brian D Strahl & Tatiana G Kutateladze

  • Posted in Nat Chem Biol, Publications
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Innate immunity: A sweet switch

August 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2162

Author: Terry L. Sheppard

Target validation: Switching domains

August 18th, 2016 by Alessio Ciulli

Nature Chemical Biology 12, 659 (2016). doi:10.1038/nchembio.2154

Author: Alessio Ciulli

Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.

Chemical synthesis: Linking up lysines

August 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2163

Author: Caitlin Deane

Small-Molecule inhibitors: Weed-control measures

August 18th, 2016 by Koichi Yoneyama

Nature Chemical Biology 12, 658 (2016). doi:10.1038/nchembio.2155

Author: Koichi Yoneyama

A high-throughput screen in the model plant Arabidopsis unveils leads for potential agents to combat Striga, a devastating root parasitic weed that affects food crops in Sub-Saharan Africa.

Gut microbiome: Branching into metabolic disease

August 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 657 (2016). doi:10.1038/nchembio.2164

Author: Mirella Bucci

Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry

August 15th, 2016 by Kei Yamaura

Nature Chemical Biology 12, 822 (2016). doi:10.1038/nchembio.2150

Authors: Kei Yamaura, Shigeki Kiyonaka, Tomohiro Numata, Ryuji Inoue & Itaru Hamachi

  • Posted in Nat Chem Biol, Publications
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TALE proteins search DNA using a rotationally decoupled mechanism

August 15th, 2016 by Luke Cuculis

Nature Chemical Biology 12, 831 (2016). doi:10.1038/nchembio.2152

Authors: Luke Cuculis, Zhanar Abil, Huimin Zhao & Charles M Schroeder