Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

May 8th, 2017 by Kadla R Rosholm

Nature Chemical Biology 13, 724 (2017). doi:10.1038/nchembio.2372

Authors: Kadla R Rosholm, Natascha Leijnse, Anna Mantsiou, Vadym Tkach, Søren L Pedersen, Volker F Wirth, Lene B Oddershede, Knud J Jensen, Karen L Martinez, Nikos S Hatzakis, Poul Martin Bendix, Andrew Callan-Jones & Dimitrios Stamou

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Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes

May 8th, 2017 by Jooyoung Park

Nature Chemical Biology 13, 730 (2017). doi:10.1038/nchembio.2376

Authors: Jooyoung Park, Andrew J Gasparrini, Margaret R Reck, Chanez T Symister, Jennifer L Elliott, Joseph P Vogel, Timothy A Wencewicz, Gautam Dantas & Niraj H Tolia

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Computational design of ligand-binding membrane receptors with high selectivity

May 1st, 2017 by Xiang Feng

Nature Chemical Biology 13, 715 (2017). doi:10.1038/nchembio.2371

Authors: Xiang Feng, Joaquin Ambia, Kuang-Yui M Chen, Melvin Young & Patrick Barth

  • Posted in Nat Chem Biol, Publications
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Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

May 1st, 2017 by Linda Lauinger

Nature Chemical Biology 13, 709 (2017). doi:10.1038/nchembio.2370

Authors: Linda Lauinger, Jing Li, Anton Shostak, Ibrahim Avi Cemel, Nati Ha, Yaru Zhang, Philipp E Merkl, Simon Obermeyer, Nicolas Stankovic-Valentin, Tobias Schafmeier, Walter J Wever, Albert A Bowers, Kyle P Carter, Amy E Palmer, Herbert Tschochner, Frauke Melchior, Raymond J Deshaies, Michael Brunner & Axel Diernfellner

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Immunology: Mind the immuno-connection gap

April 24th, 2017 by Wolfgang Link

Nature Chemical Biology 13, 572 (2017). doi:10.1038/nchembio.2373

Author: Wolfgang Link

Biologic drugs that modulate the immune system have revolutionized the therapeutic landscape for several selected cancer types. A new study reports an image-based assay system to monitor cell–cell interactions, identifying small-molecule compounds with immunomodulatory capacity.

Protein degradation: DCAFinating splicing

April 24th, 2017 by Georg E Winter

Nature Chemical Biology 13, 575 (2017). doi:10.1038/nchembio.2378

Author: Georg E Winter

Chemical control of protein homeostasis and induction of protein destabilization are emerging therapeutic strategies. Two recent studies identify a set of sulfonamides that can modulate the CRL4DCAF15 E3 ligase complex to target the splicing factor RBM39 for proteasomal degradation.

Global survey of the immunomodulatory potential of common drugs

April 24th, 2017 by Gregory I Vladimer

Nature Chemical Biology 13, 681 (2017). doi:10.1038/nchembio.2360

Authors: Gregory I Vladimer, Berend Snijder, Nikolaus Krall, Johannes W Bigenzahn, Kilian V M Huber, Charles-Hugues Lardeau, Kumar Sanjiv, Anna Ringler, Ulrika Warpman Berglund, Monika Sabler, Oscar Lopez de la Fuente, Paul Knöbl, Stefan Kubicek, Thomas Helleday, Ulrich Jäger & Giulio Superti-Furga

Selective degradation of splicing factor CAPERα by anticancer sulfonamides

April 24th, 2017 by Taisuke Uehara

Nature Chemical Biology 13, 675 (2017). doi:10.1038/nchembio.2363

Authors: Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi, Kaoru Ogawa Mitsuhashi, Noboru Yamamoto, Hiroshi Kamiyama, Kentaro Takahashi, Yoshihiko Kotake, Mai Uesugi, Akira Yokoi, Atsushi Inoue, Taku Yoshida, Miyuki Mabuchi, Akito Tanaka & Takashi Owa

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Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

April 17th, 2017 by Menglu Wang

Nature Chemical Biology 13, 660 (2017). doi:10.1038/nchembio.2361

Authors: Menglu Wang, Lucile Moynié, Peter J Harrison, Van Kelly, Andrew Piper, James H Naismith & Dominic J Campopiano

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The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

April 17th, 2017 by Paola Estrada

Nature Chemical Biology 13, 668 (2017). doi:10.1038/nchembio.2359

Authors: Paola Estrada, Miglena Manandhar, Shi-Hui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal, John E Cronan & Satish K Nair

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