RNA structure: Widening the probe

December 16th, 2016 by Grant Miura

Nature Chemical Biology 13, 1 (2017). doi:10.1038/nchembio.2274

Author: Grant Miura

Natural products: Mapping an amazing thicket

December 16th, 2016 by Mark E Horsman

Nature Chemical Biology 13, 6 (2017). doi:10.1038/nchembio.2265

Authors: Mark E Horsman & Christopher N Boddy

The Global Natural Products Social Molecular Networking (GNPS) resource and the DEREPLICATOR algorithm provide new tools for analyzing mass spectral data and enabling natural products discovery.

RAS signaling: Divide and conquer

December 16th, 2016 by Matthew Holderfield

Nature Chemical Biology 13, 7 (2017). doi:10.1038/nchembio.2264

Authors: Matthew Holderfield & Deborah K Morrison

The role of RAS dimerization in tumor biology is an emerging area of preclinical cancer research. Characterization of a RAS monobody indicates that dimer formation is required for RAS signaling, revealing the dimer interface as a potential drug target.

Rewiring human cellular input–output using modular extracellular sensors

December 12th, 2016 by Kelly A Schwarz

Nature Chemical Biology 13, 202 (2017). doi:10.1038/nchembio.2253

Authors: Kelly A Schwarz, Nichole M Daringer, Taylor B Dolberg & Joshua N Leonard

  • Posted in Nat Chem Biol, Publications
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Single-molecule analysis reveals multi-state folding of a guanine riboswitch

December 12th, 2016 by Vishnu Chandra

Nature Chemical Biology 13, 194 (2017). doi:10.1038/nchembio.2252

Authors: Vishnu Chandra, Zain Hannan, Huizhong Xu & Maumita Mandal

  • Posted in Nat Chem Biol, Publications
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Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

December 12th, 2016 by Ruchi Jain Dey

Nature Chemical Biology 13, 210 (2017). doi:10.1038/nchembio.2254

Authors: Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Gyanu Lamichhane, Herman O Sintim & William R Bishai

  • Posted in Nat Chem Biol, Publications
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Precise small-molecule recognition of a toxic CUG RNA repeat expansion

December 12th, 2016 by Suzanne G Rzuczek

Nature Chemical Biology 13, 188 (2017). doi:10.1038/nchembio.2251

Authors: Suzanne G Rzuczek, Lesley A Colgan, Yoshio Nakai, Michael D Cameron, Denis Furling, Ryohei Yasuda & Matthew D Disney

  • Posted in Nat Chem Biol, Publications
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A human microprotein that interacts with the mRNA decapping complex

December 5th, 2016 by Nadia G D'Lima

Nature Chemical Biology 13, 174 (2017). doi:10.1038/nchembio.2249

Authors: Nadia G D'Lima, Jiao Ma, Lauren Winkler, Qian Chu, Ken H Loh, Elizabeth O Corpuz, Bogdan A Budnik, Jens Lykke-Andersen, Alan Saghatelian & Sarah A Slavoff

Quantitating drug-target engagement in single cells in vitro and in vivo

December 5th, 2016 by J Matthew Dubach

Nature Chemical Biology 13, 168 (2017). doi:10.1038/nchembio.2248

Authors: J Matthew Dubach, Eunha Kim, Katherine Yang, Michael Cuccarese, Randy J Giedt, Labros G Meimetis, Claudio Vinegoni & Ralph Weissleder

  • Posted in Nat Chem Biol, Publications
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Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine

December 5th, 2016 by Monica Yun Liu

Nature Chemical Biology 13, 181 (2017). doi:10.1038/nchembio.2250

Authors: Monica Yun Liu, Hedieh Torabifard, Daniel J Crawford, Jamie E DeNizio, Xing-Jun Cao, Benjamin A Garcia, G Andrés Cisneros & Rahul M Kohli

  • Posted in Nat Chem Biol, Publications
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