Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

March 27th, 2017 by Stephanie M Stanford

Nature Chemical Biology 13, 624 (2017). doi:10.1038/nchembio.2344

Authors: Stephanie M Stanford, Alexander E Aleshin, Vida Zhang, Robert J Ardecky, Michael P Hedrick, Jiwen Zou, Santhi R Ganji, Matthew R Bliss, Fusayo Yamamoto, Andrey A Bobkov, Janna Kiselar, Yingge Liu, Gregory W Cadwell, Shilpi Khare, Jinghua Yu, Antonio Barquilla, Thomas D Y Chung, Tomas Mustelin, Simon Schenk, Laurie A Bankston, Robert C Liddington, Anthony B Pinkerton & Nunzio Bottini

  • Posted in Nat Chem Biol, Publications
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Chemical screening identifies ATM as a target for alleviating senescence

March 27th, 2017 by Hyun Tae Kang

Nature Chemical Biology 13, 616 (2017). doi:10.1038/nchembio.2342

Authors: Hyun Tae Kang, Joon Tae Park, Kobong Choi, Yongsub Kim, Hyo Jei Claudia Choi, Chul Won Jung, Young-Sam Lee & Sang Chul Park

  • Posted in Nat Chem Biol, Publications
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Near-infrared optogenetic pair for protein regulation and spectral multiplexing

March 27th, 2017 by Taras A Redchuk

Nature Chemical Biology 13, 633 (2017). doi:10.1038/nchembio.2343

Authors: Taras A Redchuk, Evgeniya S Omelina, Konstantin G Chernov & Vladislav V Verkhusha

  • Posted in Nat Chem Biol, Publications
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Structural and functional insight into human O-GlcNAcase

March 27th, 2017 by Christian Roth

Nature Chemical Biology 13, 610 (2017). doi:10.1038/nchembio.2358

Authors: Christian Roth, Sherry Chan, Wendy A Offen, Glyn R Hemsworth, Lianne I Willems, Dustin T King, Vimal Varghese, Robert Britton, David J Vocadlo & Gideon J Davies

O-GlcNAc hydrolase (OGA) removes O-linked N-acetylglucosamine (O-GlcNAc) from a myriad of nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments, we determined the three-dimensional structure of human OGA, revealing an unusual helix-exchanged dimer that lays a structural foundation for an improved understanding of substrate recognition and regulation of OGA. Structures of OGA in complex with a series of inhibitors define a precise blueprint for the design of inhibitors that have clinical value.

Development: Marking the transition

March 22nd, 2017 by Grant Miura

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2349

Author: Grant Miura

Fatty acid synthases: Re-engineering biofactories

March 22nd, 2017 by Timm Maier

Nature Chemical Biology 13, 344 (2017). doi:10.1038/nchembio.2338

Author: Timm Maier

Systematically modifying biological assembly lines for the synthesis of novel products remains a challenge. Structural insights and computational modeling have now paved the way for efficient redesigns of giant fatty acid synthases.

Bioconjugation: Methionine’s time to shine

March 22nd, 2017 by Caitlin Deane

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2350

Author: Caitlin Deane

Imaging: Luciferase matchmaker

March 22nd, 2017 by Caitlin Deane

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2352

Author: Caitlin Deane

Versatile modes of cellular regulation via cyclic dinucleotides

March 22nd, 2017 by Petya Violinova Krasteva

Nature Chemical Biology 13, 350 (2017). doi:10.1038/nchembio.2337

Authors: Petya Violinova Krasteva & Holger Sondermann

Signaling: Spatial regulation of axonal cAMP

March 22nd, 2017 by Pierre Vincent

Nature Chemical Biology 13, 348 (2017). doi:10.1038/nchembio.2339

Authors: Pierre Vincent & Liliana R Castro

In early-stage developing neurons, the cAMP–PKA (protein kinase A) signaling pathway is strongly inhibited. This negative control is later removed, unleashing cAMP–PKA signaling, particularly in distal axonal parts, thus allowing for axonal growth.