Akt3 is a privileged first responder in isozyme-specific electrophile response

January 23rd, 2017 by Marcus J C Long

Nature Chemical Biology 13, 333 (2017). doi:10.1038/nchembio.2284

Authors: Marcus J C Long, Saba Parvez, Yi Zhao, Sanjna L Surya, Yiran Wang, Sheng Zhang & Yimon Aye

  • Posted in Nat Chem Biol, Publications
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Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis

January 23rd, 2017 by Yi Zou

Nature Chemical Biology 13, 325 (2017). doi:10.1038/nchembio.2283

Authors: Yi Zou, Marc Garcia-Borràs, Mancheng C Tang, Yuichiro Hirayama, Dehai H Li, Li Li, Kenji Watanabe, K N Houk & Yi Tang

  • Posted in Nat Chem Biol, Publications
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Redox regulation: Taking AKTion on HNEs

January 23rd, 2017 by Eranthie Weerapana

Nature Chemical Biology 13, 244 (2017). doi:10.1038/nchembio.2311

Author: Eranthie Weerapana

Differential redox regulation of kinase isoforms serves to provide intricate control of cellular signaling events. In a new study, a single isoform of Akt, Akt3, is shown to be preferentially modified by lipid-derived electrophiles to modulate downstream signaling events in mammalian cells and zebrafish.

Synthetic biology: Sensing with modular receptors

January 19th, 2017 by Matthew Brenner

Nature Chemical Biology 13, 131 (2017). doi:10.1038/nchembio.2290

Authors: Matthew Brenner, Jang Hwan Cho & Wilson W Wong

Sensing and responding to diverse extracellular signals is a crucial aspect of cellular decision-making that is currently lacking in the synthetic biology toolkit. The development of modular receptor platforms allows for the rewiring of cellular input–output relationships.

Susan Lindquist (1949–2016)

January 19th, 2017 by Tricia R Serio

Nature Chemical Biology 13, 127 (2017). doi:10.1038/nchembio.2305

Author: Tricia R Serio

Susan Lindquist passed away on 27 October 2016, far too early for those who marveled at her brilliance through her many contributions to science, for all who knew her directly, and especially for her former trainees.

RNA modification: Reading Sex-lethal

January 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2291

Author: Grant Miura

Nitrogenase: A fuel-producing microbe

January 19th, 2017 by Holger Dobbek

Nature Chemical Biology 13, 134 (2017). doi:10.1038/nchembio.2288

Author: Holger Dobbek

Nitrogenase has the canonical ability to reduce N2 to NH3, but under certain conditions, either in vitro or in vivo, it has the additional capability to convert CO2 to CO and CO to light hydrocarbons.

Biosynthesis: Terrifically tailored peptides

January 19th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2292

Author: Caitlin Deane

Host-Pathogen interactions: Nucleotide circles of life and death

January 19th, 2017 by Lingyin Li

Nature Chemical Biology 13, 130 (2017). doi:10.1038/nchembio.2289

Author: Lingyin Li

A phosphodiesterase, CdnP, from Mycobacterium tuberculosis (M. tb.) helps the pathogen evade immune detection by degrading the second messenger cyclic di-AMP that alerts the host to its presence. Genetic knockout of CdnP dampens the virulence of the pathogen, suggesting that CdnP inhibitors are potential anti–M. tb. therapeutics.

Pancreatic development: Changing identity

January 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2293

Author: Grant Miura