The RNA helicase Mtr4p is a duplex-sensing translocase

November 21st, 2016 by Eric M Patrick

Nature Chemical Biology 13, 99 (2017). doi:10.1038/nchembio.2234

Authors: Eric M Patrick, Sukanya Srinivasan, Eckhard Jankowsky & Matthew J Comstock

A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

November 21st, 2016 by John C Rose

Nature Chemical Biology 13, 119 (2017). doi:10.1038/nchembio.2244

Authors: John C Rose, Po-Ssu Huang, Nathan D Camp, Jordan Ye, Andrew M Leidal, Inna Goreshnik, Bridget M Trevillian, Miles S Dickinson, Daniel Cunningham-Bryant, Jayanta Debnath, David Baker, Alejandro Wolf-Yadlin & Dustin J Maly

  • Posted in Nat Chem Biol, Publications
  • Comments Off on A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

Ubiquitin utilizes an acidic surface patch to alter chromatin structure

November 21st, 2016 by Galia T Debelouchina

Nature Chemical Biology 13, 105 (2017). doi:10.1038/nchembio.2235

Authors: Galia T Debelouchina, Karola Gerecht & Tom W Muir

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Ubiquitin utilizes an acidic surface patch to alter chromatin structure

Nuclear receptors: PPARα ligands make memories

November 15th, 2016 by Thomas P Burris

Nature Chemical Biology 12, 993 (2016). doi:10.1038/nchembio.2241

Author: Thomas P Burris

Three newly identified endogenous ligands of the nuclear receptor PPARα—hydroxydimethylbutyrate, hexadecanamide and octadecenamide—are implicated in the noncanonical activity of PPARα in synaptic function and hippocampal plasticity.

Photosynthesis: Short circuit at the chlorophyll

November 15th, 2016 by Marc M Nowaczyk

Nature Chemical Biology 12, 990 (2016). doi:10.1038/nchembio.2240

Authors: Marc M Nowaczyk & Nicolas Plumeré

Interfacing photosynthetic proteins and electrodes for investigating light-induced charge separation remains challenging. The discovery of a competing charge transfer pathway through the light-harvesting antenna defines new design requirements for electrode modification.

Immunology: T cells get L-ARGed

November 15th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2256

Author: Mirella Bucci

Protein synthesis: Breaking down the NSA1

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2258

Author: Grant Miura

Epigenomics: Massive ATAC

November 15th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2257

Author: Joshua M. Finkelstein

Drug discovery: Doubling down on BET inhibition

November 15th, 2016 by Dafydd Owen

Nature Chemical Biology 12, 991 (2016). doi:10.1038/nchembio.2242

Author: Dafydd Owen

Through simultaneous binding to more than one site in a single protein, multivalent small molecules can achieve huge increases in potency. This 'avidity effect' has been demonstrated in BET bromodomain-containing proteins with bivalent probes that represent some of the most potent BET inhibitors to date.

RNA structure: Know when to fold ’em

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2255

Author: Grant Miura