Drug discovery: Uncoupling coupled transport

March 22nd, 2017 by Mirella Bucci

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2351

Author: Mirella Bucci

Development: Marking the transition

March 22nd, 2017 by Grant Miura

Nature Chemical Biology 13, 343 (2017). doi:10.1038/nchembio.2349

Author: Grant Miura

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges

March 20th, 2017 by Vinayak Agarwal

Nature Chemical Biology 13, 537 (2017). doi:10.1038/nchembio.2330

Authors: Vinayak Agarwal, Jessica M Blanton, Sheila Podell, Arnaud Taton, Michelle A Schorn, Julia Busch, Zhenjian Lin, Eric W Schmidt, Paul R Jensen, Valerie J Paul, Jason S Biggs, James W Golden, Eric E Allen & Bradley S Moore

  • Posted in Nat Chem Biol, Publications
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A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

March 20th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 551 (2017). doi:10.1038/nchembio.2336

Authors: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis

March 20th, 2017 by Marta C Marques

Nature Chemical Biology 13, 544 (2017). doi:10.1038/nchembio.2335

Authors: Marta C Marques, Cristina Tapia, Oscar Gutiérrez-Sanz, Ana Raquel Ramos, Kimberly L Keller, Judy D Wall, Antonio L De Lacey, Pedro M Matias & Inês A C Pereira

  • Posted in Nat Chem Biol, Publications
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The Rrp4–exosome complex recruits and channels substrate RNA by a unique mechanism

March 13th, 2017 by Milos A Cvetkovic

Nature Chemical Biology 13, 522 (2017). doi:10.1038/nchembio.2328

Authors: Milos A Cvetkovic, Jan Philip Wurm, Maxime J Audin, Stefan Schütz & Remco Sprangers

  • Posted in Nat Chem Biol, Publications
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In silico design of novel probes for the atypical opioid receptor MRGPRX2

March 13th, 2017 by Katherine Lansu

Nature Chemical Biology 13, 529 (2017). doi:10.1038/nchembio.2334

Authors: Katherine Lansu, Joel Karpiak, Jing Liu, Xi-Ping Huang, John D McCorvy, Wesley K Kroeze, Tao Che, Hiroshi Nagase, Frank I Carroll, Jian Jin, Brian K Shoichet & Bryan L Roth

  • Posted in Nat Chem Biol, Publications
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Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

March 13th, 2017 by Shasha Li

Nature Chemical Biology 13, 467 (2017). doi:10.1038/nchembio.2327

Authors: Shasha Li, Andrew N Lowell, Sean A Newmister, Fengan Yu, Robert M Williams & David H Sherman

The formation of C–C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole- and fischerindole- type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug development. Here we determine the biochemical basis for tri- and tetracyclic core formation in these secondary metabolites, involving a new class of cyclases that catalyze a complex cyclization cascade.

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Structural basis of PROTAC cooperative recognition for selective protein degradation

March 13th, 2017 by Morgan S Gadd

Nature Chemical Biology 13, 514 (2017). doi:10.1038/nchembio.2329

Authors: Morgan S Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J Lamont, Michael Zengerle & Alessio Ciulli

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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

March 6th, 2017 by Andrew M Intlekofer

Nature Chemical Biology 13, 494 (2017). doi:10.1038/nchembio.2307

Authors: Andrew M Intlekofer, Bo Wang, Hui Liu, Hardik Shah, Carlos Carmona-Fontaine, Ariën S Rustenburg, Salah Salah, M R Gunner, John D Chodera, Justin R Cross & Craig B Thompson

  • Posted in Nat Chem Biol, Publications
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