Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

November 14th, 2016 by Ryan S Nett

Nature Chemical Biology 13, 69 (2017). doi:10.1038/nchembio.2232

Authors: Ryan S Nett, Mariana Montanares, Ariana Marcassa, Xuan Lu, Raimund Nagel, Trevor C Charles, Peter Hedden, Maria Cecilia Rojas & Reuben J Peters

  • Posted in Nat Chem Biol, Publications
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Ferroptosis: Oxidized PEs trigger death

November 14th, 2016 by Katharina D'Herde

Nature Chemical Biology 13, 4 (2017). doi:10.1038/nchembio.2261

Authors: Katharina D'Herde & Dmitri V Krysko

Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

November 14th, 2016 by Sebastian Doll

Nature Chemical Biology 13, 91 (2017). doi:10.1038/nchembio.2239

Authors: Sebastian Doll, Bettina Proneth, Yulia Y Tyurina, Elena Panzilius, Sho Kobayashi, Irina Ingold, Martin Irmler, Johannes Beckers, Michaela Aichler, Axel Walch, Holger Prokisch, Dietrich Trümbach, Gaowei Mao, Feng Qu, Hulya Bayir, Joachim Füllekrug, Christina H Scheel, Wolfgang Wurst, Joel A Schick, Valerian E Kagan, José Pedro Friedmann Angeli & Marcus Conrad

  • Posted in Nat Chem Biol, Publications
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Tunable thermal bioswitches for in vivo control of microbial therapeutics

November 14th, 2016 by Dan I Piraner

Nature Chemical Biology 13, 75 (2017). doi:10.1038/nchembio.2233

Authors: Dan I Piraner, Mohamad H Abedi, Brittany A Moser, Audrey Lee-Gosselin & Mikhail G Shapiro

  • Posted in Nat Chem Biol, Publications
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Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

November 7th, 2016 by Carika Weldon

Nature Chemical Biology 13, 18 (2017). doi:10.1038/nchembio.2228

Authors: Carika Weldon, Isabelle Behm-Ansmant, Laurence H Hurley, Glenn A Burley, Christiane Branlant, Ian C Eperon & Cyril Dominguez

RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.

  • Posted in Nat Chem Biol, Publications
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DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

November 7th, 2016 by Marian C Okondo

Nature Chemical Biology 13, 46 (2017). doi:10.1038/nchembio.2229

Authors: Marian C Okondo, Darren C Johnson, Ramya Sridharan, Eun Bin Go, Ashley J Chui, Mitchell S Wang, Sarah E Poplawski, Wengen Wu, Yuxin Liu, Jack H Lai, David G Sanford, Michael O Arciprete, Todd R Golub, William W Bachovchin & Daniel A Bachovchin

  • Posted in Nat Chem Biol, Publications
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Inhibition of RAS function through targeting an allosteric regulatory site

November 7th, 2016 by Russell Spencer-Smith

Nature Chemical Biology 13, 62 (2017). doi:10.1038/nchembio.2231

Authors: Russell Spencer-Smith, Akiko Koide, Yong Zhou, Raphael R Eguchi, Fern Sha, Priyanka Gajwani, Dianicha Santana, Ankit Gupta, Miranda Jacobs, Erika Herrero-Garcia, Jacqueline Cobbert, Hugo Lavoie, Matthew Smith, Thanashan Rajakulendran, Evan Dowdell, Mustafa Nazir Okur, Irina Dementieva, Frank Sicheri, Marc Therrien, John F Hancock, Mitsuhiko Ikura, Shohei Koide & John P O'Bryan

  • Posted in Nat Chem Biol, Publications
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Non-classical transpeptidases yield insight into new antibacterials

November 7th, 2016 by Pankaj Kumar

Nature Chemical Biology 13, 54 (2017). doi:10.1038/nchembio.2237

Authors: Pankaj Kumar, Amit Kaushik, Evan P Lloyd, Shao-Gang Li, Rohini Mattoo, Nicole C Ammerman, Drew T Bell, Alexander L Perryman, Trevor A Zandi, Sean Ekins, Stephan L Ginell, Craig A Townsend, Joel S Freundlich & Gyanu Lamichhane

Genetic engineering: Chemical control for CRISPR editing

November 7th, 2016 by Isaac B Hilton

Nature Chemical Biology 13, 2 (2017). doi:10.1038/nchembio.2243

Authors: Isaac B Hilton & Charles A Gersbach

New approaches allow tight control over Cas9 activity using chemical induction. These studies expand the ability to rapidly induce and suppress Cas9-mediated nuclease activity and conditionally modulate the multiplex regulation of endogenous gene expression.

Dereplication of peptidic natural products through database search of mass spectra

October 31st, 2016 by Hosein Mohimani

Nature Chemical Biology 13, 30 (2017). doi:10.1038/nchembio.2219

Authors: Hosein Mohimani, Alexey Gurevich, Alla Mikheenko, Neha Garg, Louis-Felix Nothias, Akihiro Ninomiya, Kentaro Takada, Pieter C Dorrestein & Pavel A Pevzner

  • Posted in Nat Chem Biol, Publications
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