RaPID hookup

March 19th, 2018 by Grant Miura

RaPID hookup

RaPID hookup, Published online: 19 March 2018; doi:10.1038/s41589-018-0030-7

RaPID hookup

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

March 19th, 2018 by Michaela Lichtenegger

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel, Published online: 19 March 2018; doi:10.1038/s41589-018-0015-6

A photoswitchable diacylglycerol enabled a screen that found critical TRPC3 lipid-sensing residues and identified a lateral fenestration in the pore domain that allows lipids to protrude into the permeation pathway to control channel gating.
  • Posted in Nat Chem Biol, Publications
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Specialized splicing

March 19th, 2018 by Caitlin Deane

Specialized splicing

Specialized splicing, Published online: 19 March 2018; doi:10.1038/s41589-018-0027-2

Specialized splicing

Whole-organism phenotypic screening for anti-infectives promoting host health

March 19th, 2018 by Anne E. Clatworthy

Whole-organism phenotypic screening for anti-infectives promoting host health

Whole-organism phenotypic screening for anti-infectives promoting host health, Published online: 19 March 2018; doi:10.1038/s41589-018-0018-3

Targeting the host during antibiotic discovery efforts is a viable strategy, and the approach has benefited from phenotypic screening of model organisms such as worms, zebrafish, and mice.
  • Posted in Nat Chem Biol, Publications
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Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

March 12th, 2018 by Sean A. Newmister

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis, Published online: 12 March 2018; doi:10.1038/s41589-018-0003-x

The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.
  • Posted in Nat Chem Biol, Publications
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Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

March 8th, 2018 by Lukas Reisky

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Published online: 08 March 2018; doi:10.1038/s41589-018-0020-9

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
  • Posted in Nat Chem Biol, Publications
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Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

March 8th, 2018 by Kiryl D. Piatkevich

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Published online: 08 March 2018; doi:10.1038/s41589-018-0023-6

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
  • Posted in Nat Chem Biol, Publications
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Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by <span class=”small-caps”>d</span>-stereospecific peptidases

March 7th, 2018 by Yong-Xin Li

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by <span class="small-caps">d</span>-stereospecific peptidases, Published online: 07 March 2018; doi:10.1038/s41589-018-0022-7

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases
  • Posted in Nat Chem Biol, Publications
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Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

March 5th, 2018 by Ariele Viacava Follis

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL, Published online: 05 March 2018; doi:10.1038/s41589-018-0011-x

Post-translational modification of residues in an intrinsically disordered region of Bcl-XL promotes interactions with its folded core and allosterically reduces affinity for proapoptotic BH3-domain-containing proteins, resulting in apoptosis.
  • Posted in Nat Chem Biol, Publications
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Folding against the wind

March 5th, 2018 by Frederick Stull

Folding against the wind

Folding against the wind, Published online: 05 March 2018; doi:10.1038/s41589-018-0016-5

Many thermodynamically unfavorable processes in biology are powered by ATP, the energy currency of the cell. New evidence suggests that chaperone-mediated protein stabilization may need to be added to that list.