<i>ykkC</i> riboswitches employ an add-on helix to adjust specificity for polyanionic ligands

August 17th, 2018 by Alla Peselis

ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands

<i>ykkC</i> riboswitches employ an add-on helix to adjust specificity for polyanionic ligands, Published online: 17 August 2018; doi:10.1038/s41589-018-0114-4

Structural analysis of PRPP and ppGpp riboswitches reveals that they employ a helical element to create a tunnel for the ligand, whose specificity is determined by the conserved nucleotides forming the tunnel and long-distance contacts.
  • Posted in Nat Chem Biol, Publications
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TA gets a PG rating

August 17th, 2018 by Mirella Bucci

TA gets a PG rating

TA gets a PG rating, Published online: 17 August 2018; doi:10.1038/s41589-018-0126-0

TA gets a PG rating

Stuck on you

August 17th, 2018 by Caitlin Deane

Stuck on you

Stuck on you, Published online: 17 August 2018; doi:10.1038/s41589-018-0124-2

Stuck on you

Mimicking cross-α amyloids

August 17th, 2018 by Meytal Landau

Mimicking cross-α amyloids

Mimicking cross-α amyloids, Published online: 17 August 2018; doi:10.1038/s41589-018-0118-0

The design of spiraling cross-α amyloid-like structures reveals fascinating supermolecular fibrils of diverse compactness and stability. The small sequence variations governing cross-α self-assembly properties concur with amyloids being basic building blocks of life and natural targets for microbial structural mimicry.

Designed peptides that assemble into cross-α amyloid-like structures

July 30th, 2018 by Shao-Qing Zhang

Designed peptides that assemble into cross-α amyloid-like structures

Designed peptides that assemble into cross-α amyloid-like structures, Published online: 30 July 2018; doi:10.1038/s41589-018-0105-5

Structural analysis reveals how certain designed peptides adopt unusual spiraling cross-α amyloid-like structures and also rearrange to helical polymers upon mutation of small nonpolar residues that are critical for packing and stabilization.
  • Posted in Nat Chem Biol, Publications
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Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

July 30th, 2018 by William H. Zhang

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS, Published online: 30 July 2018; doi:10.1038/s41589-018-0108-2

A genetically encoded FRET-based optical sensor generated from a computational design approach can monitor hippocampal glycine levels in brain tissue to determine differences between spines and shafts and changes induced by high- and low-frequency stimulation.
  • Posted in Nat Chem Biol, Publications
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A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells

July 30th, 2018 by Esther Braselmann

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells, Published online: 30 July 2018; doi:10.1038/s41589-018-0103-7

A new riboswitch-based RNA sensor called Riboglow binds to quenched fluorescent probes to induce fluorescence turn-on. Riboglow enables tagging and tracking of mRNA and short noncoding RNAs with different colored fluorophores in live mammalian cells.
  • Posted in Nat Chem Biol, Publications
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Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

July 30th, 2018 by Ron Hermenau

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system, Published online: 30 July 2018; doi:10.1038/s41589-018-0101-9

Plant-associated rhizosphere bacteria produce gramibactin, a cyclic lipodepsipeptide siderophore that tightly binds iron via an unexpected functional group, the N-nitrosohydroxylamine (diazeniumdiolate) moieties of the amino acid graminine.
  • Posted in Nat Chem Biol, Publications
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Dopamine gets lit

July 17th, 2018 by Mirella Bucci

Dopamine gets lit

Dopamine gets lit, Published online: 17 July 2018; doi:10.1038/s41589-018-0111-7

Dopamine gets lit

A remote control for switching

July 17th, 2018 by Marc Vendrell

A remote control for switching

A remote control for switching, Published online: 17 July 2018; doi:10.1038/s41589-018-0107-3

Calcium channels are crucial regulators of a broad range of biological processes. A photoswitchable chemical probe allows the opening and closing of these channels with unprecedented temporal resolution, providing new opportunities to study calcium-dependent signaling pathways in real time.