Functional annotation of chemical libraries across diverse biological processes
July 24th, 2017 by Jeff S Piotrowski
Nature Chemical Biology 13, 982 (2017). doi:10.1038/nchembio.2436
Authors: Jeff S Piotrowski, Sheena C Li, Raamesh Deshpande, Scott W Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A Gebre, Karen Kubo, Nikko P Torres, Marissa A LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L Myers & Charles Boone
Copper import in Escherichia coli by the yersiniabactin metallophore system
July 24th, 2017 by Eun-Ik Koh
Nature Chemical Biology 13, 1016 (2017). doi:10.1038/nchembio.2441
Authors: Eun-Ik Koh, Anne E Robinson, Nilantha Bandara, Buck E Rogers & Jeffrey P Henderson
FRET monitoring of a nonribosomal peptide synthetase
July 24th, 2017 by Jonas Alfermann
Nature Chemical Biology 13, 1009 (2017). doi:10.1038/nchembio.2435
Authors: Jonas Alfermann, Xun Sun, Florian Mayerthaler, Thomas E Morrell, Eva Dehling, Gerrit Volkmann, Tamiki Komatsuzaki, Haw Yang & Henning D Mootz
Toxicity and repair of DNA adducts produced by the natural product yatakemycin
July 24th, 2017 by Elwood A Mullins
Nature Chemical Biology 13, 1002 (2017). doi:10.1038/nchembio.2439
Authors: Elwood A Mullins, Rongxin Shi & Brandt F Eichman
Peptidomimetic inhibitors of APC–Asef interaction block colorectal cancer migration
July 24th, 2017 by Haiming Jiang
Nature Chemical Biology 13, 994 (2017). doi:10.1038/nchembio.2442
Authors: Haiming Jiang, Rong Deng, Xiuyan Yang, Jialin Shang, Shaoyong Lu, Yanlong Zhao, Kun Song, Xinyi Liu, Qiufen Zhang, Yu Chen, Y Eugene Chinn, Geng Wu, Jian Li, Guoqiang Chen, Jianxiu Yu & Jian Zhang
Erratum: Structural and conformational determinants of macrocycle cell permeability
July 18th, 2017 by Björn Over
Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922a
Author: Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall & Jan Kihlberg
Biocatalysis: Achieving aminase activity
July 18th, 2017 by Caitlin Deane
Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2447
Author: Caitlin Deane
Harnessing yeast organelles for metabolic engineering
July 18th, 2017 by Sarah K Hammer
Nature Chemical Biology 13, 823 (2017). doi:10.1038/nchembio.2429
Authors: Sarah K Hammer & José L Avalos
Structural biology: Full monty of family B GPCRs
July 18th, 2017 by Thue W Schwartz
Nature Chemical Biology 13, 819 (2017). doi:10.1038/nchembio.2438
Authors: Thue W Schwartz & Thomas M Frimurer
New structures of the glucagon-like peptide-1 (GLP-1) and glucagon receptors in complex with peptide and nonpeptide ligands provide a comprehensive, detailed picture of the molecular mechanisms of action of family B GPCRs. This opens the door for true structure-based drug discovery aimed at both novel orthosteric and allosteric subsites of the receptors.
Hints of hidden chemistry
July 18th, 2017 by Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology 13, 815 (2017). doi:10.1038/nchembio.2449
Biosynthetic pathways harbor diverse enzyme functions, and identifying those that catalyze unusual or synthetically challenging transformations offers new routes for biocatalytic development.