Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

May 29th, 2017 by Casey L Quinlan

Nature Chemical Biology 13, 785 (2017). doi:10.1038/nchembio.2384

Authors: Casey L Quinlan, Stephen E Kaiser, Ben Bolaños, Dawn Nowlin, Rita Grantner, Shannon Karlicek-Bryant, Jun Li Feng, Stephen Jenkinson, Kevin Freeman-Cook, Stephen G Dann, Xiaoli Wang, Peter A Wells, Valeria R Fantin, Al E Stewart & Stephan K Grant

  • Posted in Nat Chem Biol, Publications
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Structural basis for high-affinity fluorophore binding and activation by RNA Mango

May 29th, 2017 by Robert J Trachman

Nature Chemical Biology 13, 807 (2017). doi:10.1038/nchembio.2392

Authors: Robert J Trachman, Natalia A Demeshkina, Matthew W L Lau, Shanker Shyam S Panchapakesan, Sunny C Y Jeng, Peter J Unrau & Adrian R Ferré-D'Amaré

  • Posted in Nat Chem Biol, Publications
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Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

May 29th, 2017 by Yuan Qiao

Nature Chemical Biology 13, 793 (2017). doi:10.1038/nchembio.2388

Authors: Yuan Qiao, Veerasak Srisuknimit, Frederick Rubino, Kaitlin Schaefer, Natividad Ruiz, Suzanne Walker & Daniel Kahne

  • Posted in Nat Chem Biol, Publications
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Structural and functional characterization of the hydrogenase-maturation HydF protein

May 29th, 2017 by Giorgio Caserta

Nature Chemical Biology 13, 779 (2017). doi:10.1038/nchembio.2385

Authors: Giorgio Caserta, Ludovic Pecqueur, Agnieszka Adamska-Venkatesh, Cecilia Papini, Souvik Roy, Vincent Artero, Mohamed Atta, Edward Reijerse, Wolfgang Lubitz & Marc Fontecave

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Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1

May 22nd, 2017 by Zhijie Li

Nature Chemical Biology 13, 757 (2017). doi:10.1038/nchembio.2381

Authors: Zhijie Li, Kristina Han, John E Pak, Malathy Satkunarajah, Dongxia Zhou & James M Rini

  • Posted in Nat Chem Biol, Publications
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Engineering RGB color vision into Escherichia coli

May 22nd, 2017 by Jesus Fernandez-Rodriguez

Nature Chemical Biology 13, 706 (2017). doi:10.1038/nchembio.2390

Authors: Jesus Fernandez-Rodriguez, Felix Moser, Miryoung Song & Christopher A Voigt

Optogenetic tools use colored light to rapidly control gene expression in space and time. We designed a genetically encoded system that gives Escherichia coli the ability to distinguish between red, green, and blue (RGB) light and respond by changing gene expression. We use this system to produce 'color photographs' on bacterial culture plates by controlling pigment production and to redirect metabolic flux by expressing CRISPRi guide RNAs.

Engineering protein stability with atomic precision in a monomeric miniprotein

May 22nd, 2017 by Emily G Baker

Nature Chemical Biology 13, 764 (2017). doi:10.1038/nchembio.2380

Authors: Emily G Baker, Christopher Williams, Kieran L Hudson, Gail J Bartlett, Jack W Heal, Kathryn L Porter Goff, Richard B Sessions, Matthew P Crump & Derek N Woolfson

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A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

May 22nd, 2017 by Marco P Licciardello

Nature Chemical Biology 13, 771 (2017). doi:10.1038/nchembio.2382

Authors: Marco P Licciardello, Anna Ringler, Patrick Markt, Freya Klepsch, Charles-Hugues Lardeau, Sara Sdelci, Erika Schirghuber, André C Müller, Michael Caldera, Anja Wagner, Rebecca Herzog, Thomas Penz, Michael Schuster, Bernd Boidol, Gerhard Dürnberger, Yasin Folkvaljon, Pär Stattin, Vladimir Ivanov, Jacques Colinge, Christoph Bock, Klaus Kratochwill, Jörg Menche, Keiryn L Bennett & Stefan Kubicek

  • Posted in Nat Chem Biol, Publications
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The perception of strigolactones in vascular plants

May 17th, 2017 by Shelley Lumba

Nature Chemical Biology 13, 599 (2017). doi:10.1038/nchembio.2340

Authors: Shelley Lumba, Duncan Holbrook-Smith & Peter McCourt

Infectious disease: A lethal sugar fix

May 17th, 2017 by Alison Farrell

Nature Chemical Biology 13, 569 (2017). doi:10.1038/nchembio.2400

Author: Alison Farrell