Selective degradation of splicing factor CAPERα by anticancer sulfonamides

April 24th, 2017 by Taisuke Uehara

Nature Chemical Biology 13, 675 (2017). doi:10.1038/nchembio.2363

Authors: Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi, Kaoru Ogawa Mitsuhashi, Noboru Yamamoto, Hiroshi Kamiyama, Kentaro Takahashi, Yoshihiko Kotake, Mai Uesugi, Akira Yokoi, Atsushi Inoue, Taku Yoshida, Miyuki Mabuchi, Akito Tanaka & Takashi Owa

  • Posted in Nat Chem Biol, Publications
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Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

April 17th, 2017 by Menglu Wang

Nature Chemical Biology 13, 660 (2017). doi:10.1038/nchembio.2361

Authors: Menglu Wang, Lucile Moynié, Peter J Harrison, Van Kelly, Andrew Piper, James H Naismith & Dominic J Campopiano

  • Posted in Nat Chem Biol, Publications
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The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

April 17th, 2017 by Paola Estrada

Nature Chemical Biology 13, 668 (2017). doi:10.1038/nchembio.2359

Authors: Paola Estrada, Miglena Manandhar, Shi-Hui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal, John E Cronan & Satish K Nair

  • Posted in Nat Chem Biol, Publications
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Microbiology: A new language for small talk

April 13th, 2017 by Yi-Ming Shi

Nature Chemical Biology 13, 453 (2017). doi:10.1038/nchembio.2362

Authors: Yi-Ming Shi & Helge B Bode

A new signal–receptor pair involved in regulating biofilm formation and virulence was detected in Vibrio cholerae. Both the signal and the transcription factor belong to common classes of natural products and receptor proteins, suggesting widespread importance of related systems in nature.

Intrinsic Disorder: Fuzzy fast feedback

April 13th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2367

Author: Mirella Bucci

Targeted protein degradation: You can glue it too!

April 13th, 2017 by Michal J Walczak

Nature Chemical Biology 13, 452 (2017). doi:10.1038/nchembio.2355

Authors: Michal J Walczak, Georg Petzold & Nicolas H Thomä

Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent degradation. Structural insight into the VHL–MZ1–BRD4 complex reveals how the rationally designed MZ1–PROTAC molecule mediates degradation of an unnatural protein substrate.

Anti-Bacterials: Out-SMARting drug resistance

April 13th, 2017 by Alison Farrell

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2368

Author: Alison Farrell

The chemical basis for electrical signaling

April 13th, 2017 by William A Catterall

Nature Chemical Biology 13, 455 (2017). doi:10.1038/nchembio.2353

Authors: William A Catterall, Goragot Wisedchaisri & Ning Zheng

Optogenetics: Lighting up kinases

April 13th, 2017 by Grant Miura

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2365

Author: Grant Miura

Bacterial Membranes: Tear down this wall

April 13th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2366

Author: Caitlin Deane