Redox regulation: Scaffolding H2O2 signaling

July 18th, 2017 by Hadley D Sikes

Nature Chemical Biology 13, 818 (2017). doi:10.1038/nchembio.2432

Author: Hadley D Sikes

Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.

Enzymology: Tracking off-targets

July 18th, 2017 by Alison Farrell

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2445

Author: Alison Farrell

Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

July 18th, 2017 by Yupeng He

Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922b

Author: Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk, Dong Cheng, Kelly L Klinge, Huan-Qiu Li, Marina Pliushchev, Mikkel A Algire, David Maag, Jun Guo, Justin Dietrich, Sanjay C Panchal, Andrew M Petros, Ramzi F Sweis, Maricel Torrent, Lance J Bigelow, Guillermo Senisterra, Fengling Li, Steven Kennedy, Qin Wu, Donald J Osterling, David J Lindley, Wenqing Gao, Scott Galasinski, Dalia Barsyte-Lovejoy, Masoud Vedadi, Fritz G Buchanan, Cheryl H Arrowsmith, Gary G Chiang, Chaohong Sun & William N Pappano

  • Posted in Nat Chem Biol, Publications
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Antibacterials: PUMmeling RNAP

July 18th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2446

Author: Terry L. Sheppard

Erratum: Structural and conformational determinants of macrocycle cell permeability

July 18th, 2017 by Björn Over

Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922a

Author: Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall & Jan Kihlberg

  • Posted in Nat Chem Biol, Publications
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Biocatalysis: Achieving aminase activity

July 18th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2447

Author: Caitlin Deane

Harnessing yeast organelles for metabolic engineering

July 18th, 2017 by Sarah K Hammer

Nature Chemical Biology 13, 823 (2017). doi:10.1038/nchembio.2429

Authors: Sarah K Hammer & José L Avalos

An excited state underlies gene regulation of a transcriptional riboswitch

July 17th, 2017 by Bo Zhao

Nature Chemical Biology 13, 968 (2017). doi:10.1038/nchembio.2427

Authors: Bo Zhao, Sharon L Guffy, Benfeard Williams & Qi Zhang

  • Posted in Nat Chem Biol, Publications
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Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

July 17th, 2017 by Deepankar Gahloth

Nature Chemical Biology 13, 975 (2017). doi:10.1038/nchembio.2434

Authors: Deepankar Gahloth, Mark S Dunstan, Daniela Quaglia, Evaldas Klumbys, Michael P Lockhart-Cairns, Andrew M Hill, Sasha R Derrington, Nigel S Scrutton, Nicholas J Turner & David Leys

  • Posted in Nat Chem Biol, Publications
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Allosteric sensitization of proapoptotic BAX

July 10th, 2017 by Jonathan R Pritz

Nature Chemical Biology 13, 961 (2017). doi:10.1038/nchembio.2433

Authors: Jonathan R Pritz, Franziska Wachter, Susan Lee, James Luccarelli, Thomas E Wales, Daniel T Cohen, Paul Coote, Gregory J Heffron, John R Engen, Walter Massefski & Loren D Walensky