Site-specific acylation of a bacterial virulence regulator attenuates infection

November 18th, 2019 by Zhenrun J. Zhang

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0392-5

Microbiota-derived butyrate acylation of the key Salmonella enterica transcriptional regulator HilA attenuates virulence of the bacteria, blocking invasion of epithelial cells in vitro and dissemination in vivo.
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Axonal dispatch of iron in neuronal signaling

November 18th, 2019 by Peng Lei

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0394-3

The regulation of brain iron homeostasis, previously thought to be cell autonomous and modulated by local factors in the interstitial fluid, is reported by Wang et al. to be strongly influenced by axonal transport of iron in an activity-dependent and unidirectional manner between functionally associated regions. The supply of iron from the ventral hippocampus to the middle prefrontal cortex subserved an anxiolytic phenotype and mediated the neuropharmacological actions of diazepam and lithium chloride in rodent models.

Choosing a mating site

November 18th, 2019 by Mirella Bucci

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0418-z

Choosing a mating site

Iodine goes viral

November 18th, 2019 by Caitlin Deane

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0416-1

Iodine goes viral

Solo act revealed to be duet

November 18th, 2019 by Mohamed Atta

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0406-3

The last step of archaeosine biosynthesis was found to involve two enzymes, the previously known ArcS with lysine transfer activity and a novel identified radical SAM enzyme named RaSEA.

Cutting actin with light

November 18th, 2019 by Qian Chen

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0410-7

Actin cytoskeletal structures are essential for many cellular processes, and cofilin is a key protein for the assembly of these highly dynamic structures. A new cofilin construct enables precise optogenetic control of actin assembly in live cells.

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

November 4th, 2019 by Tyler B. Faust

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0378-3

Cryo-EM and crystal structural analysis of DDB1–DCAF15–DDA1 in complex with E7820 and RBM39 reveal that aryl-sulfonamides reshape the surface of the cullin RING ligase substrate receptor DCAF15 to bind and degrade the splicing factor RBM39.
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Two-site recognition of <i>Staphylococcus aureus</i> peptidoglycan by lysostaphin SH3b

November 4th, 2019 by Luz S. Gonzalez-Delgado

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0393-4

A structural look at the interaction between the SH3b domain of the peptidoglycan endopeptidase lysostaphin and the target for its antistaphylococcal activity, peptidoglycan, reveals a mechanism of bacterial cell wall binding.
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De novo-designed translation-repressing riboregulators for multi-input cellular logic

November 4th, 2019 by Jongmin Kim

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0388-1

Two programmable riboregulator systems, based on toehold and three-way junction RNA motifs, were designed and validated as robust translational repressors in cells and applied for the construction of logic gates.
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Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

October 28th, 2019 by Zhenhua Shao

Nature Chemical Biology, Published online: 28 October 2019; doi:10.1038/s41589-019-0387-2

A crystal structure of the GPCR target of endocannabinoid signaling lipids and drugs, CB1, bound to a negative allosteric modulator (NAM) and an agonist, shows that the NAM binds to a membrane-embedded site reminiscent of the binding site of cholesterol.
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