Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

July 31st, 2017 by David D Shock

Nature Chemical Biology 13, 1074 (2017). doi:10.1038/nchembio.2450

Authors: David D Shock, Bret D Freudenthal, William A Beard & Samuel H Wilson

  • Posted in Nat Chem Biol, Publications
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Copper import in Escherichia coli by the yersiniabactin metallophore system

July 24th, 2017 by Eun-Ik Koh

Nature Chemical Biology 13, 1016 (2017). doi:10.1038/nchembio.2441

Authors: Eun-Ik Koh, Anne E Robinson, Nilantha Bandara, Buck E Rogers & Jeffrey P Henderson

  • Posted in Nat Chem Biol, Publications
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FRET monitoring of a nonribosomal peptide synthetase

July 24th, 2017 by Jonas Alfermann

Nature Chemical Biology 13, 1009 (2017). doi:10.1038/nchembio.2435

Authors: Jonas Alfermann, Xun Sun, Florian Mayerthaler, Thomas E Morrell, Eva Dehling, Gerrit Volkmann, Tamiki Komatsuzaki, Haw Yang & Henning D Mootz

Toxicity and repair of DNA adducts produced by the natural product yatakemycin

July 24th, 2017 by Elwood A Mullins

Nature Chemical Biology 13, 1002 (2017). doi:10.1038/nchembio.2439

Authors: Elwood A Mullins, Rongxin Shi & Brandt F Eichman

  • Posted in Nat Chem Biol, Publications
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Peptidomimetic inhibitors of APC–Asef interaction block colorectal cancer migration

July 24th, 2017 by Haiming Jiang

Nature Chemical Biology 13, 994 (2017). doi:10.1038/nchembio.2442

Authors: Haiming Jiang, Rong Deng, Xiuyan Yang, Jialin Shang, Shaoyong Lu, Yanlong Zhao, Kun Song, Xinyi Liu, Qiufen Zhang, Yu Chen, Y Eugene Chinn, Geng Wu, Jian Li, Guoqiang Chen, Jianxiu Yu & Jian Zhang

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Functional annotation of chemical libraries across diverse biological processes

July 24th, 2017 by Jeff S Piotrowski

Nature Chemical Biology 13, 982 (2017). doi:10.1038/nchembio.2436

Authors: Jeff S Piotrowski, Sheena C Li, Raamesh Deshpande, Scott W Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A Gebre, Karen Kubo, Nikko P Torres, Marissa A LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L Myers & Charles Boone

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Structural biology: Full monty of family B GPCRs

July 18th, 2017 by Thue W Schwartz

Nature Chemical Biology 13, 819 (2017). doi:10.1038/nchembio.2438

Authors: Thue W Schwartz & Thomas M Frimurer

New structures of the glucagon-like peptide-1 (GLP-1) and glucagon receptors in complex with peptide and nonpeptide ligands provide a comprehensive, detailed picture of the molecular mechanisms of action of family B GPCRs. This opens the door for true structure-based drug discovery aimed at both novel orthosteric and allosteric subsites of the receptors.

Hints of hidden chemistry

July 18th, 2017 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 13, 815 (2017). doi:10.1038/nchembio.2449

Biosynthetic pathways harbor diverse enzyme functions, and identifying those that catalyze unusual or synthetically challenging transformations offers new routes for biocatalytic development.

Biosynthesis: Methylating mushrooms

July 18th, 2017 by Albert A Bowers

Nature Chemical Biology 13, 821 (2017). doi:10.1038/nchembio.2437

Author: Albert A Bowers

The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.

Neurodegenerative disease: Not stuck on repeat

July 18th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2444

Author: Mirella Bucci