Tricks for taking up residence

June 18th, 2018 by Mirella Bucci

Tricks for taking up residence

Tricks for taking up residence, Published online: 18 June 2018; doi:10.1038/s41589-018-0094-4

Tricks for taking up residence

Stabilizing synapsis

June 18th, 2018 by Yiyun Song

Stabilizing synapsis

Stabilizing synapsis, Published online: 18 June 2018; doi:10.1038/s41589-018-0095-3

Stabilizing synapsis

Linkers for protein degradation

June 11th, 2018 by Philip P. Chamberlain

Linkers for protein degradation

Linkers for protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0057-9

The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

June 11th, 2018 by Benoit Castrec

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern, Published online: 11 June 2018; doi:10.1038/s41589-018-0077-5

Aided by the solving of the structures of human NMT1 with substrate-mimicking peptides, mapping of human and Arabidopsis myristoylomes defines a myristoylation recognition motif and over 1,000 myristoylated protein targets.
  • Posted in Nat Chem Biol, Publications
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Plasticity in binding confers selectivity in ligand-induced protein degradation

June 11th, 2018 by Radosław P. Nowak

Plasticity in binding confers selectivity in ligand-induced protein degradation

Plasticity in binding confers selectivity in ligand-induced protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0055-y

Selectivity of ligand-induced protein degradation and dimerization is conferred by plastic interprotein contacts. Computational protein–protein docking reveals the underlying interprotein contacts to inform the design of a BRD4 selective degrader.
  • Posted in Nat Chem Biol, Publications
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Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

June 4th, 2018 by Jianchao Li

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins, Published online: 04 June 2018; doi:10.1038/s41589-018-0082-8

Potent pan-Atg8 or GABARAP-selective inhibitory peptides derived from giant neuronal ankyrin-B and -G effectively block autophagy in cell cultures and in C. elegans spatiotemporally.
  • Posted in Nat Chem Biol, Publications
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Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

June 4th, 2018 by Nan Wang

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme, Published online: 04 June 2018; doi:10.1038/s41589-018-0061-0

Functional and structural characterization of PtmA2 reveals that it is an unusual non-adenylating acyl-CoA ligase and part of a system wherein the canonical acyl-CoA ligase reaction is separated into two half-reactions performed by distinct enzymes.
  • Posted in Nat Chem Biol, Publications
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Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system

June 4th, 2018 by Tong Xiao

Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system

Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system, Published online: 04 June 2018; doi:10.1038/s41589-018-0062-z

Copper contributes to regulating zebrafish rest–activity cycles through the locus coeruleus system by modulating the biosynthesis of norepinephrine; brain copper deficiency leads to lower levels of both synaptic norepinephrine and daytime activity.
  • Posted in Nat Chem Biol, Publications
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Functional assignment of multiple catabolic pathways for <span class=”small-caps”>d</span>-apiose

June 4th, 2018 by Michael S. Carter

Functional assignment of multiple catabolic pathways for d-apiose

Functional assignment of multiple catabolic pathways for <span class="small-caps">d</span>-apiose, Published online: 04 June 2018; doi:10.1038/s41589-018-0067-7

A bioinformatic strategy beginning with solute-binding proteins involved in sugar transport led to the functional annotation of four previously unknown catabolic pathways of the branched pentose d-apiose.
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A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

May 28th, 2018 by Xue Chen

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis, Published online: 28 May 2018; doi:10.1038/s41589-018-0059-7

Although the conversion of (7S)-salutaridinol 7-O-acetate to thebaine can occur spontaneously, the identification of a thebaine synthase enzyme that catalyzes the reaction indicates how nature avoids the formation of labile hydroxylated byproducts.
  • Posted in Nat Chem Biol, Publications
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