Synthetic beta cells for fusion-mediated dynamic insulin secretion

October 30th, 2017 by Zhaowei Chen

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Synthetic beta cells for fusion-mediated dynamic insulin secretion, Published online: 30 October 2017; doi:10.1038/nchembio.2511

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Synthetic beta cells were fabricated through 'vesicles-in-vesicle' liposomal superstructures equipped with glucose-sensing and membrane-fusion machinery, thus enabling sensing of graded glucose levels and secretion of insulin via fusion processes.

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PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides

October 30th, 2017 by David Sychantha

PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides

PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides, Published online: 30 October 2017; doi:10.1038/nchembio.2509

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A chemically synthesized analog of Bacillus cereus secondary cell wall polysaccharide (SCWP) facilitates the identification of PatB1 as a SCWP O-acetyltransferase, and the structure of PatB1 provides insights into its catalytic mechanism.

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Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

October 30th, 2017 by Yi Qu

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer, Published online: 30 October 2017; doi:10.1038/nchembio.2510

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The small molecule nitazoxanide (NTZ) was identified as a Wnt inhibitor by promoting protein citrullination of β-catenin through increased cytosolic calcium and PAD2 protein stabilization. β-catenin citrullination results in proteasomal degradation.

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Rational design of proteins that exchange on functional timescales

October 23rd, 2017 by James A Davey

Rational design of proteins that exchange on functional timescales

Rational design of proteins that exchange on functional timescales, Published online: 23 October 2017; doi:10.1038/nchembio.2503

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The development of a computational protein design method, meta-multistate design, enables the design and validation of protein variants termed DANCERs that spontaneously exchange between predicted conformational states on the millisecond timescale.

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A CRISPR screen identifies a pathway required for paraquat-induced cell death

October 23rd, 2017 by Colleen R Reczek

A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death, Published online: 23 October 2017; doi:10.1038/nchembio.2499

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A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

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Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

October 23rd, 2017 by Chia-Wei Hu

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase, Published online: 23 October 2017; doi:10.1038/nchembio.2494

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N-Acetylglucosamine derivatives equipped with electrophilic groups and handles for subsequent chemical tagging are useful probes of substrate recognition by O-GlcNAc transferases and enable the capture of transient protein substrates of these enzymes.

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Bacterial cell wall: Phages breaking free

October 18th, 2017 by Karin Kuehnel

Bacterial cell wall: Phages breaking free

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2506

Biomaterials: Cotton gets superpowers

October 18th, 2017 by Caitlin Deane

Biomaterials: Cotton gets superpowers

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2505

Host-microbe interactions: Aiming at GPCRs

October 18th, 2017 by Mirella Bucci

Host-microbe interactions: Aiming at GPCRs

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2507

Drug discovery: Controlling protein SUMOylation

October 18th, 2017 by John S Schneekloth Jr

Drug discovery: Controlling protein SUMOylation

Nature Chemical Biology, Published online: 18 October 2017; doi:10.1038/nchembio.2496

A potent and selective inhibitor of protein SUMOylation, a ubiquitin-like post-translational modification, has been developed, shedding light on the potential for developing new classes of anticancer therapeutics.