An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

March 19th, 2018 by Michaela Lichtenegger

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel, Published online: 19 March 2018; doi:10.1038/s41589-018-0015-6

A photoswitchable diacylglycerol enabled a screen that found critical TRPC3 lipid-sensing residues and identified a lateral fenestration in the pore domain that allows lipids to protrude into the permeation pathway to control channel gating.
  • Posted in Nat Chem Biol, Publications
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Specialized splicing

March 19th, 2018 by Caitlin Deane

Specialized splicing

Specialized splicing, Published online: 19 March 2018; doi:10.1038/s41589-018-0027-2

Specialized splicing

Whole-organism phenotypic screening for anti-infectives promoting host health

March 19th, 2018 by Anne E. Clatworthy

Whole-organism phenotypic screening for anti-infectives promoting host health

Whole-organism phenotypic screening for anti-infectives promoting host health, Published online: 19 March 2018; doi:10.1038/s41589-018-0018-3

Targeting the host during antibiotic discovery efforts is a viable strategy, and the approach has benefited from phenotypic screening of model organisms such as worms, zebrafish, and mice.
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Structural basis for backbone N-methylation by an interrupted adenylation domain

March 19th, 2018 by Shogo Mori

Structural basis for backbone N-methylation by an interrupted adenylation domain

Structural basis for backbone N-methylation by an interrupted adenylation domain, Published online: 19 March 2018; doi:10.1038/s41589-018-0014-7

The crystal structure of a methyltransferase domain embedded within an interrupted adenylation domain provides insight into how a nonribosomal peptide synthetase N-methylates amino acid precursors for their incorporation into the peptide product.
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Mix and match

March 19th, 2018 by Karin Kuehnel

Mix and match

Mix and match, Published online: 19 March 2018; doi:10.1038/s41589-018-0028-1

Mix and match

Discovery of enzymes for toluene synthesis from anoxic microbial communities

March 19th, 2018 by Harry R. Beller

Discovery of enzymes for toluene synthesis from anoxic microbial communities

Discovery of enzymes for toluene synthesis from anoxic microbial communities, Published online: 19 March 2018; doi:10.1038/s41589-018-0017-4

The source of biological toluene production in diverse anoxic microbial communities is a glycyl radical enzyme that catalyzes phenylacetate decarboxylation (PhdB), and its cognate activating radical S-adenosylmethionine enzyme (PhdA).
  • Posted in Nat Chem Biol, Publications
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A ‘cis’ted localization

March 19th, 2018 by Mirella Bucci

A ‘cis’ted localization

A ‘cis’ted localization, Published online: 19 March 2018; doi:10.1038/s41589-018-0029-0

A ‘cis’ted localization

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

March 12th, 2018 by Sean A. Newmister

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis, Published online: 12 March 2018; doi:10.1038/s41589-018-0003-x

The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.
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Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

March 8th, 2018 by Lukas Reisky

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Published online: 08 March 2018; doi:10.1038/s41589-018-0020-9

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
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Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

March 8th, 2018 by Kiryl D. Piatkevich

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Published online: 08 March 2018; doi:10.1038/s41589-018-0023-6

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
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