Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

January 29th, 2018 by Marie Couturier

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation, Published online: 29 January 2018; doi:10.1038/nchembio.2558

A new type of fungal lytic polysaccharide monooxygenase (LPMO) catalyzes the oxidative degradation of xylan components of cellulosic biomass and offers potential in wood biorefining.
  • Posted in Nat Chem Biol, Publications
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Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

January 22nd, 2018 by Naoyuki Uchida

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair, Published online: 22 January 2018; doi:10.1038/nchembio.2555

A synthetic, orthogonal pair of the plant hormone auxin and its receptor TIR1 was engineered to hijack auxin signaling without interfering with the endogenous system. The synthetic system conclusively demonstrates the role for TIR1 in auxin-induced acid growth.
  • Posted in Nat Chem Biol, Publications
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A whole-animal platform to advance a clinical kinase inhibitor into new disease space

January 22nd, 2018 by Masahiro Sonoshita

A whole-animal platform to advance a clinical kinase inhibitor into new disease space

A whole-animal platform to advance a clinical kinase inhibitor into new disease space, Published online: 22 January 2018; doi:10.1038/nchembio.2556

Combining Drosophila genetics with chemistry and computation led to the development of novel kinase inhibitors based on the RAF-targeting drug sorafenib that reveal the RET oncogene as an enhancer of drug action and improve the therapeutic window in medullary thyroid carcinoma models.
  • Posted in Nat Chem Biol, Publications
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Toward an orthogonal central dogma

January 16th, 2018 by Chang C Liu

Toward an orthogonal central dogma

Toward an orthogonal central dogma, Published online: 16 January 2018; doi:10.1038/nchembio.2554

The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion of the roles of these processes within the cell.

Cell biology: Eaten up from the inside

January 16th, 2018 by Karin Kuehnel

Cell biology: Eaten up from the inside

Cell biology: Eaten up from the inside, Published online: 16 January 2018; doi:10.1038/nchembio.2563

Cell biology: Eaten up from the inside

Plant hormones: Metabolic end run to jasmonate

January 16th, 2018 by Gregg A Howe

Plant hormones: Metabolic end run to jasmonate

Plant hormones: Metabolic end run to jasmonate, Published online: 16 January 2018; doi:10.1038/nchembio.2553

The lipid-derived hormone jasmonate promotes durable resistance of plants to a myriad of herbivores and pathogens. New evidence reveals an alternative pathway for the terminal steps of jasmonate biosynthesis and further advances our understanding of bioactive oxylipins in the plant kingdom.

RNA Splicing: Making the cut

January 16th, 2018 by Stéphane Larochelle

RNA Splicing: Making the cut

RNA Splicing: Making the cut, Published online: 16 January 2018; doi:10.1038/nchembio.2564

RNA Splicing: Making the cut

Drug development: Allosteric inhibitors hit USP7 hard

January 16th, 2018 by Wei Zhang

Drug development: Allosteric inhibitors hit USP7 hard

Drug development: Allosteric inhibitors hit USP7 hard, Published online: 16 January 2018; doi:10.1038/nchembio.2557

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases

January 16th, 2018 by David I Bryson

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases, Published online: 16 January 2018; doi:10.1038/nchembio0218-186

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases

Synthetic biology: License to kill

January 16th, 2018 by Caitlin Deane

Synthetic biology: License to kill

Synthetic biology: License to kill, Published online: 16 January 2018; doi:10.1038/nchembio.2561

Synthetic biology: License to kill