Protein evolution: Hacking an enzyme

February 14th, 2018 by Kristoffer E Johansson

Protein evolution: Hacking an enzyme

Protein evolution: Hacking an enzyme, Published online: 14 February 2018; doi:10.1038/nchembio.2574

Early stages of protein evolution are inherently difficult to study. Genetic selection in Escherichia coli has now identified a life-sustaining de novo enzyme arising from a simple scaffold that is completely different from the native enzyme.

Altering form for function

February 14th, 2018 by Nature Chemical Biology - Issue - nature.com science feeds

Altering form for function

Altering form for function, Published online: 14 February 2018; doi:10.1038/nchembio.2582

Elucidating the mechanisms by which biomolecules are chemically modified and how these alterations regulate biological pathways represents a leading frontier in chemical biology.

Viruses: Capsids under pressure

February 14th, 2018 by Mirella Bucci

Viruses: Capsids under pressure

Viruses: Capsids under pressure, Published online: 14 February 2018; doi:10.1038/nchembio.2578

Viruses: Capsids under pressure

How many human proteoforms are there?

February 14th, 2018 by Ruedi Aebersold

How many human proteoforms are there?

How many human proteoforms are there?, Published online: 14 February 2018; doi:10.1038/nchembio.2576

How many human proteoforms are there?

Insights into the biogenesis, function, and regulation of ADP-ribosylation

February 14th, 2018 by Michael S Cohen

Insights into the biogenesis, function, and regulation of ADP-ribosylation

Insights into the biogenesis, function, and regulation of ADP-ribosylation, Published online: 14 February 2018; doi:10.1038/nchembio.2568

Insights into the biogenesis, function, and regulation of ADP-ribosylation
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RNA structure: A LASER-focused view into cells

February 14th, 2018 by Philip C Bevilacqua

RNA structure: A LASER-focused view into cells

RNA structure: A LASER-focused view into cells, Published online: 14 February 2018; doi:10.1038/nchembio.2570

RNA structure is irrevocably linked to function. A new method, termed 'LASER', utilizes a light-activated chemical probe to query RNA tertiary structure and illuminate RNA–protein interactions in the living cell.

The ABCs of PTMs

February 14th, 2018 by Karl W Barber

The ABCs of PTMs

The ABCs of PTMs, Published online: 14 February 2018; doi:10.1038/nchembio.2572

Post-translational modifications (PTMs) are ubiquitous in all forms of life and often modulate critical protein functions. Recent chemical and biological advances have finally enabled scientists to precisely modify proteins at physiologically relevant positions, ushering in a new era of protein studies.

Ubiquitination: Trashing the CIA

February 14th, 2018 by Grant Miura

Ubiquitination: Trashing the CIA

Ubiquitination: Trashing the CIA, Published online: 14 February 2018; doi:10.1038/nchembio.2580

Ubiquitination: Trashing the CIA

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

January 29th, 2018 by Hao Yin

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Published online: 29 January 2018; doi:10.1038/nchembio.2559

Partial substitution of CRISPR RNAs with DNA nucleotides retains CRISPR–Cas9 genome editing activity while enhancing efficiency and specificity within cells, suggesting that DNA–RNA hybrids may be economical reagents for targeted genome editing.
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Rewiring T-cell responses to soluble factors with chimeric antigen receptors

January 29th, 2018 by ZeNan L Chang

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

Rewiring T-cell responses to soluble factors with chimeric antigen receptors, Published online: 29 January 2018; doi:10.1038/nchembio.2565

Chimeric antigen receptor (CAR)-expressing T cells were engineered to recognize soluble protein ligands that, by inducing CAR dimerization, mechanically couple ligand binding and receptor signaling to produce immune effector molecules.
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