Structural basis for backbone N-methylation by an interrupted adenylation domain

March 19th, 2018 by Shogo Mori

Structural basis for backbone N-methylation by an interrupted adenylation domain

Structural basis for backbone N-methylation by an interrupted adenylation domain, Published online: 19 March 2018; doi:10.1038/s41589-018-0014-7

The crystal structure of a methyltransferase domain embedded within an interrupted adenylation domain provides insight into how a nonribosomal peptide synthetase N-methylates amino acid precursors for their incorporation into the peptide product.
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Mix and match

March 19th, 2018 by Karin Kuehnel

Mix and match

Mix and match, Published online: 19 March 2018; doi:10.1038/s41589-018-0028-1

Mix and match

Discovery of enzymes for toluene synthesis from anoxic microbial communities

March 19th, 2018 by Harry R. Beller

Discovery of enzymes for toluene synthesis from anoxic microbial communities

Discovery of enzymes for toluene synthesis from anoxic microbial communities, Published online: 19 March 2018; doi:10.1038/s41589-018-0017-4

The source of biological toluene production in diverse anoxic microbial communities is a glycyl radical enzyme that catalyzes phenylacetate decarboxylation (PhdB), and its cognate activating radical S-adenosylmethionine enzyme (PhdA).
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A ‘cis’ted localization

March 19th, 2018 by Mirella Bucci

A ‘cis’ted localization

A ‘cis’ted localization, Published online: 19 March 2018; doi:10.1038/s41589-018-0029-0

A ‘cis’ted localization

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

March 12th, 2018 by Sean A. Newmister

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis, Published online: 12 March 2018; doi:10.1038/s41589-018-0003-x

The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.
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Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

March 8th, 2018 by Lukas Reisky

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Published online: 08 March 2018; doi:10.1038/s41589-018-0020-9

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
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Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

March 8th, 2018 by Kiryl D. Piatkevich

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Published online: 08 March 2018; doi:10.1038/s41589-018-0023-6

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
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Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by <span class=”small-caps”>d</span>-stereospecific peptidases

March 7th, 2018 by Yong-Xin Li

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by <span class="small-caps">d</span>-stereospecific peptidases, Published online: 07 March 2018; doi:10.1038/s41589-018-0022-7

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases
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Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins

March 5th, 2018 by Pierre Goloubinoff

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins, Published online: 05 March 2018; doi:10.1038/s41589-018-0013-8

A nonequilibrium thermodynamic model can explain how molecular chaperones such as GroEL can use the energy from ATP hydrolysis to maintain substrate proteins in an active state, even under conditions that favor the substrate’s inactive unfolded state.
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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

March 5th, 2018 by Lara N. Gechijian

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands, Published online: 05 March 2018; doi:10.1038/s41589-018-0010-y

Selective TRIM24 degradation is achieved by co-opting the VHL E3 ubiquitin ligase machinery. TRIM24 degradation outperforms bromodomain inhibition, with an enhanced antiproliferative effect in acute leukemia, a novel context of TRIM24 dependency.
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