Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

November 4th, 2019 by Tyler B. Faust

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0378-3

Cryo-EM and crystal structural analysis of DDB1–DCAF15–DDA1 in complex with E7820 and RBM39 reveal that aryl-sulfonamides reshape the surface of the cullin RING ligase substrate receptor DCAF15 to bind and degrade the splicing factor RBM39.
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Two-site recognition of <i>Staphylococcus aureus</i> peptidoglycan by lysostaphin SH3b

November 4th, 2019 by Luz S. Gonzalez-Delgado

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0393-4

A structural look at the interaction between the SH3b domain of the peptidoglycan endopeptidase lysostaphin and the target for its antistaphylococcal activity, peptidoglycan, reveals a mechanism of bacterial cell wall binding.
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De novo-designed translation-repressing riboregulators for multi-input cellular logic

November 4th, 2019 by Jongmin Kim

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0388-1

Two programmable riboregulator systems, based on toehold and three-way junction RNA motifs, were designed and validated as robust translational repressors in cells and applied for the construction of logic gates.
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Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

October 28th, 2019 by Zhenhua Shao

Nature Chemical Biology, Published online: 28 October 2019; doi:10.1038/s41589-019-0387-2

A crystal structure of the GPCR target of endocannabinoid signaling lipids and drugs, CB1, bound to a negative allosteric modulator (NAM) and an agonist, shows that the NAM binds to a membrane-embedded site reminiscent of the binding site of cholesterol.
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Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation

October 28th, 2019 by Shuai Wang

Nature Chemical Biology, Published online: 28 October 2019; doi:10.1038/s41589-019-0379-2

Small molecules that achieve selective PARP1 degradation were developed that block both the catalytic activity and scaffolding effects of PARP1, enabling the decoupling of PARP1 inhibition and PARP1 trapping.
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Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

October 23rd, 2019 by Louise Fets

Nature Chemical Biology, Published online: 23 October 2019; doi:10.1038/s41589-019-0409-0

Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
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Disorder guides order

October 21st, 2019 by Yiyun Song

Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0398-z

Disorder guides order

Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

October 21st, 2019 by Gloria Yang

Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0386-3

Ancestral protein reconstruction followed by biochemical and structural analyses characterizes the evolutionary trajectory of methyl-parathion hydrolase from an ancestral dihydrocoumarin hydrolase through the accumulation of five key mutations.
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Extracellular phosphorylation in axon pathfinding

October 21st, 2019 by Patricia T. Yam

Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0383-6

The growth and guidance of axons dictate their trajectories and are critical for neural-circuit formation. Research in this issue uncovers a new mechanism for regulation of axon growth and guidance that acts via extracellular phosphorylation of a receptor.

An inside job

October 21st, 2019 by Caitlin Deane

Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0395-2

An inside job