The root of the cause

September 20th, 2019 by Grant Miura

Nature Chemical Biology, Published online: 20 September 2019; doi:10.1038/s41589-019-0376-5

The root of the cause

Colibactin comes to light

September 20th, 2019 by Caitlin Deane

Nature Chemical Biology, Published online: 20 September 2019; doi:10.1038/s41589-019-0373-8

Colibactin comes to light

First contact

September 20th, 2019 by Yiyun Song

Nature Chemical Biology, Published online: 20 September 2019; doi:10.1038/s41589-019-0375-6

First contact

A NAMe-tag for ALS

September 20th, 2019 by Mirella Bucci

Nature Chemical Biology, Published online: 20 September 2019; doi:10.1038/s41589-019-0374-7

A NAMe-tag for ALS

Development of targeted protein degradation therapeutics

September 16th, 2019 by Philip P. Chamberlain

Nature Chemical Biology, Published online: 16 September 2019; doi:10.1038/s41589-019-0362-y

This Perspective summarizes recent discoveries that have laid the foundation for targeted degradation therapeutics and discusses the current state of understanding and consideration involved in developing these protein degraders.

DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription

September 16th, 2019 by M. Semer

Nature Chemical Biology, Published online: 16 September 2019; doi:10.1038/s41589-019-0354-y

KAT2A acetylates histone variant H2A.Z to regulate transactivation of XPC and RAR positively regulated genes. The DNA repair complex XPC–RAD23–CEN2 interacts with H2A.Z and KAT2A to license the latter’s histone acetyltransferase activity.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription

Versatile biomanufacturing through stimulus-responsive cell–material feedback

September 16th, 2019 by Zhuojun Dai

Nature Chemical Biology, Published online: 16 September 2019; doi:10.1038/s41589-019-0357-8

Encapsulation of engineered bacteria in environmentally responsive materials enables on-demand protein production coupled to downstream processes such as protein purification, on-chip enzyme kinetics and metabolic production of fatty acids.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Versatile biomanufacturing through stimulus-responsive cell–material feedback

Dynamic membrane topology in an unassembled membrane protein

September 9th, 2019 by Maximilian Seurig

Nature Chemical Biology, Published online: 09 September 2019; doi:10.1038/s41589-019-0356-9

The topology of homodimeric membrane protein EmrE is dynamic and includes unassisted flipping of an N-terminal helix in and out of the membrane long after co-translational insertion. Dimerization locks the helix to limit topological dynamics.

Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

September 9th, 2019 by Mohamed M. Elshenawy

Nature Chemical Biology, Published online: 09 September 2019; doi:10.1038/s41589-019-0352-0

Single-molecule analysis revealed that the velocity and force generation of the mammalian dynein–dynactin complex is regulated by activating adaptors and tail–tail interactions between two dyneins.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

The tail wags the motor

September 9th, 2019 by Richard J. McKenney

Nature Chemical Biology, Published online: 09 September 2019; doi:10.1038/s41589-019-0367-6

Cytoplasmic dynein is a complex molecular motor that steps along microtubules. Advanced biophysical measurements reveal a surprising role for the dynein tail domain in the allosteric control of dynein’s mechanochemistry within assemblies composed of multiple dynein motors.