Cuticle thickness affects dynamics of volatile emission from petunia flowers
October 19th, 2020 by Pan Liao
Nature Chemical Biology, Published online: 19 October 2020; doi:10.1038/s41589-020-00670-w
The plant cuticle was initially thought to act as a passive diffusion barrier. Genetic and metabolic analysis reveals that it is also a sink/concentrator for volatiles protecting cells from toxic effects of these hydrophobic compounds.Clarifying the translational potential of B-I09
October 16th, 2020 by Juan R. Del Valle
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00654-w
Clarifying the translational potential of B-I09Kinase ins and outs
October 16th, 2020 by Mirella Bucci
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00682-6
Kinase ins and outsReversal of nucleobase methylation by dioxygenases
October 16th, 2020 by Guo-Liang Xu
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00675-5
This Review summarizes the chemical and physical properties of methylated nucleobases in DNA and RNA, proposes a chemical classification of methylation types, and discusses recent advance in demethylation reactions mediated by dioxygenases.Fine-tuning adhesives
October 16th, 2020 by Grant Miura
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00681-7
Fine-tuning adhesivesLaunching the missile
October 16th, 2020 by Yiyun Song
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00683-5
Launching the missileIt’s a trap!
October 16th, 2020 by Caitlin Deane
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00680-8
It’s a trap!Advanced rules of relays
October 16th, 2020 by Sonja Lorenz
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-0632-8
Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.Hijacking protein degradation
October 16th, 2020 by Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00685-3
Targeted protein degradation provides a powerful complement to small-molecule inhibition in modulating protein activity and allows access to otherwise intractable drug targets.Peroxisome compartmentalization of a toxic enzyme improves alkaloid production
October 12th, 2020 by Parbir S. Grewal
Nature Chemical Biology, Published online: 12 October 2020; doi:10.1038/s41589-020-00668-4
Increased production of (S)-reticuline and other alkaloids is achieved through alleviating norcoclaurine synthase toxicity by targeting the enzyme to the peroxisome plus enlarging peroxisomes by expression of engineered transcription factors.