Disorder is a critical component of lipoprotein sorting in Gram-negative bacteria

July 29th, 2021 by Jessica El Rayes

Nature Chemical Biology, Published online: 29 July 2021; doi:10.1038/s41589-021-00845-z

Approximately half of lipoproteins destined to the Escherichia coli outer membrane display intrinsically disordered linker peptides at their N termini, which are required for optimal trafficking by the Lol lipoprotein sorting system.
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Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

July 26th, 2021 by Wei Jiang

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00836-0

A survey of natural metabolic pathways for C1 substrates (methane, methanol, carbon dioxide, and carbon monoxide) highlights past efforts and recent progress, and informs future opportunities to create synthetic C1-utilizing microbes.
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Prospecting for natural products by genome mining and microcrystal electron diffraction

July 26th, 2021 by Lee Joon Kim

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00834-2

Combined use of microcrystal electron diffraction and genome mining for biosynthetic gene clusters enables the rapid structural elucidation of natural products, including a newly discovered 2-pyridone compound and a revised structure of fischerin.
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Untying knots with force

July 26th, 2021 by Pan T. X. Li

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00856-w

RNA knot-like structures function as an efficient physical barrier to RNA exoribonucleases. Single-molecule mechanical manipulation is used to unfold these structures and unravel the cause of their unusual mechanical resistance from a different direction.

Central dogma, redefined

July 26th, 2021 by Yiyun Song

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00850-2

Central dogma, redefined

A molecular shape-shifter

July 26th, 2021 by Karin Kühnel

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00848-w

A molecular shape-shifter

Picking off persisters

July 26th, 2021 by Caitlin Deane

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00847-x

Picking off persisters

Mucin tuning

July 26th, 2021 by Philip Lössl

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00849-9

Mucin tuning

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

July 22nd, 2021 by Daniel B. Grabarczyk

Nature Chemical Biology, Published online: 22 July 2021; doi:10.1038/s41589-021-00831-5

The full-length structure of HUWE1 reveals the bipartite organization of a giant E3 ubiquitin ligase, comprising a catalytic HECT domain and a large, ring-shaped scaffold that provides docking sites for various substrates and regulates E3 activity.
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Mechanical strength of RNA knot in Zika virus protects against cellular defenses

July 12th, 2021 by Meng Zhao

Nature Chemical Biology, Published online: 12 July 2021; doi:10.1038/s41589-021-00829-z

A knot-like RNA from Zika virus is shown to evade digestion by host RNases through its extreme resistance to mechanical unfolding. Weakening the knot mechanically or reducing the likelihood of knot formation lowers the RNase resistance.
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