Polarized displacement by transcription activator-like effectors for regulatory circuits

November 19th, 2018 by Tina Lebar

Polarized displacement by transcription activator-like effectors for regulatory circuits

Polarized displacement by transcription activator-like effectors for regulatory circuits, Published online: 19 November 2018; doi:10.1038/s41589-018-0163-8

The observation that transcription activator-like effectors (TALES) displace TALES bound at adjacent downstream DNA enables engineered regulation of gene expression, displacement of other DNA binding proteins and construction of logic-gated systems.
  • Posted in Nat Chem Biol, Publications
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Metal Enterococcus equipment

November 14th, 2018 by Mirella Bucci

Metal Enterococcus equipment

Metal Enterococcus equipment, Published online: 14 November 2018; doi:10.1038/s41589-018-0173-6

Metal Enterococcus equipment

Devilish diatoms

November 14th, 2018 by Caitlin Deane

Devilish diatoms

Devilish diatoms, Published online: 14 November 2018; doi:10.1038/s41589-018-0175-4

Devilish diatoms

Transcriptional recorder

November 14th, 2018 by Yiyun Song

Transcriptional recorder

Transcriptional recorder, Published online: 14 November 2018; doi:10.1038/s41589-018-0174-5

Transcriptional recorder

Expanding the terpenoid kingdom

November 14th, 2018 by Yongjin J. Zhou

Expanding the terpenoid kingdom

Expanding the terpenoid kingdom, Published online: 14 November 2018; doi:10.1038/s41589-018-0167-4

Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.

Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation

November 14th, 2018 by Amanda Poissonnier

Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation

Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation, Published online: 14 November 2018; doi:10.1038/s41589-018-0162-9

The HIV protease inhibitor ritonavir targets the calcium-inducing domain (CID) of CD95 to block interactions with PLCγ1. Peptidomimetics targeting the CD95 CID prevents accumulation of inflammatory Th17 cells observed in systemic lupus erythematosus.
  • Posted in Nat Chem Biol, Publications
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Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering

November 14th, 2018 by Codruta Ignea

Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering

Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering, Published online: 14 November 2018; doi:10.1038/s41589-018-0166-5

Yeast engineered to produce the six-carbon terpene building block 2-methyl-geranyl diphosphate, coupled with terpene synthases engineered to accept this noncanonical substrate, enables the biosynthesis of a collection of new C11 terpenoid scaffolds.
  • Posted in Nat Chem Biol, Publications
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Failure to convert

November 14th, 2018 by Grant Miura

Failure to convert

Failure to convert, Published online: 14 November 2018; doi:10.1038/s41589-018-0172-7

Failure to convert

Identification of <i>Chaoborus</i> kairomone chemicals that induce defences in <i>Daphnia</i>

November 14th, 2018 by Linda C. Weiss

Identification of Chaoborus kairomone chemicals that induce defences in Daphnia

Identification of <i>Chaoborus</i> kairomone chemicals that induce defences in <i>Daphnia</i>, Published online: 14 November 2018; doi:10.1038/s41589-018-0164-7

The freshwater microcrustacean Daphnia pulex forms defensive neckteeth in response to a collection of chemical cues (the kairomone), now identified as certain fatty acids conjugated to glutamine, released during digestion by its predator Chaoborus.
  • Posted in Nat Chem Biol, Publications
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HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

November 5th, 2018 by Huanbin Wang

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity, Published online: 05 November 2018; doi:10.1038/s41589-018-0161-x

HIP1R directly interacts with PD-L1 and targets PD-L1 for lysosomal degradation. Development of a rationally designed peptide incorporating the PD-L1 binding sequence of HIP1R with a lysosomal targeting sequence promotes PD-L1 degradation.
  • Posted in Nat Chem Biol, Publications
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