ACS DIVISION OF BIOLOGICAL CHEMISTRY

April 16th, 2018 by David A. Dougan

Understanding the Pro/N-end rule pathway

Understanding the Pro/N-end rule pathway, Published online: 16 April 2018; doi:10.1038/s41589-018-0045-0

Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of substrates by this proteolytic system.

April 16th, 2018 by Caitlin Deane

Spotting the signal

Spotting the signal, Published online: 16 April 2018; doi:10.1038/s41589-018-0047-y

Spotting the signal

April 16th, 2018 by Marina Santiago

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic, Published online: 16 April 2018; doi:10.1038/s41589-018-0041-4

Use of a combined Tn-seq and machine-learning approach for predicting mechanisms and targets of antibiotic action in Staphylococcus aureus shows that the natural product lysocin E (LysE) binds Lipid II on the cell surface and damages the membrane.

April 16th, 2018 by Grant Miura

Fueled by light

Fueled by light, Published online: 16 April 2018; doi:10.1038/s41589-018-0048-x

Fueled by light

April 16th, 2018 by Mirella Bucci

The peptide d-list

The peptide <span class="small-caps">d</span>-list, Published online: 16 April 2018; doi:10.1038/s41589-018-0049-9

The peptide d-list

April 16th, 2018 by Yiyun Song

Structure in sequence

Structure in sequence, Published online: 16 April 2018; doi:10.1038/s41589-018-0050-3

Structure in sequence

April 16th, 2018 by Aakash Basu

Dynamic coupling between conformations and nucleotide states in DNA gyrase

Dynamic coupling between conformations and nucleotide states in DNA gyrase, Published online: 16 April 2018; doi:10.1038/s41589-018-0037-0

Single-molecule measurements of DNA gyrase activity reveal conformational dynamics coupling ATP consumption to DNA supercoiling.

April 16th, 2018 by Conan K. Wang

Designing macrocyclic disulfide-rich peptides for biotechnological applications

Designing macrocyclic disulfide-rich peptides for biotechnological applications, Published online: 16 April 2018; doi:10.1038/s41589-018-0039-y

Through molecular grafting, cyclic disulfide-rich peptides can be used as scaffolds to improve the stability, rigidity, and cellular uptake of bioactive peptides, although a number of factors should be considered when designing such grafted peptides.

April 2nd, 2018 by Michael M. Gaschler

FINO₂ initiates ferroptosis through GPX4 inactivation and iron oxidation

FINO₂ initiates ferroptosis through GPX4 inactivation and iron oxidation, Published online: 02 April 2018; doi:10.1038/s41589-018-0031-6

FINO2 is a small molecule that requires the endoperoxide moiety and hydroxyl group to promote ferroptosis through indirect inhibition of GPX4 enzymatic function and direct oxidation of iron, resulting in increased lipid peroxidation.

April 2nd, 2018 by Taka A. Tsunoyama

Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function

Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function, Published online: 02 April 2018; doi:10.1038/s41589-018-0032-5

Dissolved oxygen and a reducing-plus-oxidizing system suppress photobleaching and photoblinking in single-molecule tracking experiments, allowing long recordings of CD47 and integrin that showed temporary immobilization within focal adhesions.