Keth-seq for transcriptome-wide RNA structure mapping

February 3rd, 2020 by Xiaocheng Weng

Nature Chemical Biology, Published online: 03 February 2020; doi:10.1038/s41589-019-0459-3

The authors designed a chemical probe, azido-kethoxal, to specifically label guanosine in single-strand RNAs in live cells that could be used to determine transcriptome-wide RNA secondary structures.

Stress-tolerant non-conventional microbes enable next-generation chemical biosynthesis

January 23rd, 2020 by Sarah Thorwall

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-019-0452-x

The native stress-tolerant phenotypes of various non-conventional microbes have the potential to enable more efficient bioprocessing for chemical production, addressing certain design challenges encountered when using model production hosts.
  • Posted in Nat Chem Biol, Publications
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Spores hit the spot

January 23rd, 2020 by Chao Zhong

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-019-0451-y

Engineered living materials (ELMs) with the qualities of both programmable functionalities and environmental tolerance are rare. 3D printing of bacterial spores into resilient living materials provides a viable route to fabricate ELMs that integrate these material attributes.

Lipid hijacking

January 23rd, 2020 by Mirella Bucci

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-020-0465-5

Lipid hijacking

Noise reduction

January 23rd, 2020 by Grant Miura

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-020-0464-6

Noise reduction

A dual function PUS enzyme

January 23rd, 2020 by Wen Zhang

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-019-0450-z

The traditional function of pseudouridine synthases is to convert uridine residues in RNA to pseudouridines. A study reveals a new function for the human PUS10 protein, which enhances micro-RNA maturation in addition to tRNA modification.

New beginnings

January 23rd, 2020 by Yiyun Song

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-020-0466-4

New beginnings

Spying on the microbiome

January 23rd, 2020 by Caitlin Deane

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-020-0463-7

Spying on the microbiome

Chris Dobson (1949–2019)

January 23rd, 2020 by Tuomas P. J. Knowles

Nature Chemical Biology, Published online: 23 January 2020; doi:10.1038/s41589-019-0456-6

Chris Dobson passed away on September 8th, leaving a wide-reaching legacy. He is best known for revealing the generality of the phenomenon of protein misfolding and aggregation and has provided inspiration for generations of researchers.

Biased modulators of NMDA receptors control channel opening and ion selectivity

January 20th, 2020 by Riley E. Perszyk

Nature Chemical Biology, Published online: 20 January 2020; doi:10.1038/s41589-019-0449-5

A series of positive allosteric modulators of NMDA receptors that can increase agonist potency, increase channel-open probability, and slow receptor deactivation can also decrease single-channel conductance and decrease calcium permeability.
  • Posted in Nat Chem Biol, Publications
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