Cuticle thickness affects dynamics of volatile emission from petunia flowers

October 19th, 2020 by Pan Liao

Nature Chemical Biology, Published online: 19 October 2020; doi:10.1038/s41589-020-00670-w

The plant cuticle was initially thought to act as a passive diffusion barrier. Genetic and metabolic analysis reveals that it is also a sink/concentrator for volatiles protecting cells from toxic effects of these hydrophobic compounds.
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Clarifying the translational potential of B-I09

October 16th, 2020 by Juan R. Del Valle

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00654-w

Clarifying the translational potential of B-I09

Kinase ins and outs

October 16th, 2020 by Mirella Bucci

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00682-6

Kinase ins and outs

Reversal of nucleobase methylation by dioxygenases

October 16th, 2020 by Guo-Liang Xu

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00675-5

This Review summarizes the chemical and physical properties of methylated nucleobases in DNA and RNA, proposes a chemical classification of methylation types, and discusses recent advance in demethylation reactions mediated by dioxygenases.

Fine-tuning adhesives

October 16th, 2020 by Grant Miura

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00681-7

Fine-tuning adhesives

Launching the missile

October 16th, 2020 by Yiyun Song

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00683-5

Launching the missile

It’s a trap!

October 16th, 2020 by Caitlin Deane

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00680-8

It’s a trap!

Advanced rules of relays

October 16th, 2020 by Sonja Lorenz

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-0632-8

Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.

Hijacking protein degradation

October 16th, 2020 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00685-3

Targeted protein degradation provides a powerful complement to small-molecule inhibition in modulating protein activity and allows access to otherwise intractable drug targets.

Peroxisome compartmentalization of a toxic enzyme improves alkaloid production

October 12th, 2020 by Parbir S. Grewal

Nature Chemical Biology, Published online: 12 October 2020; doi:10.1038/s41589-020-00668-4

Increased production of (S)-reticuline and other alkaloids is achieved through alleviating norcoclaurine synthase toxicity by targeting the enzyme to the peroxisome plus enlarging peroxisomes by expression of engineered transcription factors.
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