Mutanofactin promotes adhesion and biofilm formation of cariogenic <i>Streptococcus mutans</i>

March 4th, 2021 by Zhong-Rui Li

Nature Chemical Biology, Published online: 04 March 2021; doi:10.1038/s41589-021-00745-2

The mutanofactin family of lipopeptide natural products, produced by strains of cariogenic Streptococcus mutans, promotes biofilm formation via increased cell-surface hydrophobicity and binding to extracellular DNA.
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Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

March 4th, 2021 by Liguo Wang

Nature Chemical Biology, Published online: 04 March 2021; doi:10.1038/s41589-021-00742-5

A selective and potent CDK2 degrader was developed that induced differentiation of acute myeloid leukemia cell lines and primary patient cells.
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Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

March 2nd, 2021 by Yilong Zou

Nature Chemical Biology, Published online: 02 March 2021; doi:10.1038/s41589-021-00767-w

Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
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Orphan receptor GPR37L1 remains unliganded

March 1st, 2021 by Tony Ngo

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00748-z

Orphan receptor GPR37L1 remains unliganded

Binding site for activator MDL-801 on SIRT6

March 1st, 2021 by Weijie You

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00749-y

Binding site for activator MDL-801 on SIRT6

Reply to: Binding site for MDL-801 on SIRT6

March 1st, 2021 by Zhimin Huang

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00750-5

Reply to: Binding site for MDL-801 on SIRT6

Oncohistones: corruption at the core

March 1st, 2021 by Kanishk Jain

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00764-z

High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.

Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

March 1st, 2021 by Tony Ngo

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00746-1

Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
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ROS regulated reversible protein phase separation synchronizes plant flowering

February 25th, 2021 by Xiaozhen Huang

Nature Chemical Biology, Published online: 25 February 2021; doi:10.1038/s41589-021-00739-0

Plants utilize naturally produced ROS in shoot apical stem cells as a developmental signal to trigger phase separation of TMF. The resulting transcriptional condensates repress expression of the floral identity gene to precisely time flowering.
  • Posted in Nat Chem Biol, Publications
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Redox control of flowering

February 25th, 2021 by Christine H. Foyer

Nature Chemical Biology, Published online: 25 February 2021; doi:10.1038/s41589-021-00758-x

Using an interdisciplinary approach, hydrogen-peroxide-induced phase separation in the intrinsically disordered regions of the TERMINATING FLOWER transcription factor proteins was shown to regulate the shoot apical meristem through repression of the floral identity gene called ANANTHA.