Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
November 4th, 2019 by Tyler B. Faust
Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0378-3
Cryo-EM and crystal structural analysis of DDB1–DCAF15–DDA1 in complex with E7820 and RBM39 reveal that aryl-sulfonamides reshape the surface of the cullin RING ligase substrate receptor DCAF15 to bind and degrade the splicing factor RBM39.Two-site recognition of <i>Staphylococcus aureus</i> peptidoglycan by lysostaphin SH3b
November 4th, 2019 by Luz S. Gonzalez-Delgado
Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0393-4
A structural look at the interaction between the SH3b domain of the peptidoglycan endopeptidase lysostaphin and the target for its antistaphylococcal activity, peptidoglycan, reveals a mechanism of bacterial cell wall binding.De novo-designed translation-repressing riboregulators for multi-input cellular logic
November 4th, 2019 by Jongmin Kim
Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0388-1
Two programmable riboregulator systems, based on toehold and three-way junction RNA motifs, were designed and validated as robust translational repressors in cells and applied for the construction of logic gates.Structure of an allosteric modulator bound to the CB1 cannabinoid receptor
October 28th, 2019 by Zhenhua Shao
Nature Chemical Biology, Published online: 28 October 2019; doi:10.1038/s41589-019-0387-2
A crystal structure of the GPCR target of endocannabinoid signaling lipids and drugs, CB1, bound to a negative allosteric modulator (NAM) and an agonist, shows that the NAM binds to a membrane-embedded site reminiscent of the binding site of cholesterol.Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation
October 28th, 2019 by Shuai Wang
Nature Chemical Biology, Published online: 28 October 2019; doi:10.1038/s41589-019-0379-2
Small molecules that achieve selective PARP1 degradation were developed that block both the catalytic activity and scaffolding effects of PARP1, enabling the decoupling of PARP1 inhibition and PARP1 trapping.Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
October 23rd, 2019 by Louise Fets
Nature Chemical Biology, Published online: 23 October 2019; doi:10.1038/s41589-019-0409-0
Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOGDisorder guides order
October 21st, 2019 by Yiyun Song
Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0398-z
Disorder guides orderHigher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme
October 21st, 2019 by Gloria Yang
Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0386-3
Ancestral protein reconstruction followed by biochemical and structural analyses characterizes the evolutionary trajectory of methyl-parathion hydrolase from an ancestral dihydrocoumarin hydrolase through the accumulation of five key mutations.Extracellular phosphorylation in axon pathfinding
October 21st, 2019 by Patricia T. Yam
Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0383-6
The growth and guidance of axons dictate their trajectories and are critical for neural-circuit formation. Research in this issue uncovers a new mechanism for regulation of axon growth and guidance that acts via extracellular phosphorylation of a receptor.An inside job
October 21st, 2019 by Caitlin Deane
Nature Chemical Biology, Published online: 21 October 2019; doi:10.1038/s41589-019-0395-2
An inside job