DNA jumps with CRISPR

July 18th, 2019 by Yiyun Song

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0335-1

DNA jumps with CRISPR

Freedom to bind

July 18th, 2019 by Mirella Bucci

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0332-4

Freedom to bind

A programmable DNA-origami platform for studying lipid transfer between bilayers

July 18th, 2019 by Xin Bian

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0325-3

Use of DNA-origami nanostructures to study lipid transfer between closely apposed membrane bilayers supports a model where phospholipids are transferred by extended synaptotagmin 1 between the endoplasmic reticulum and plasma membrane through a shuttle mechanism.
  • Posted in Nat Chem Biol, Publications
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PROSPECTing for drugs

July 18th, 2019 by Grant Miura

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0334-2

PROSPECTing for drugs

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

July 18th, 2019 by Matthew Ravalin

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0322-6

The C termini sequences recognized by E3 ubiquitin ligase CHIP were identified via a peptide library screen. Caspase cleavage caused the exposure of aspartic acid at the C termini of Tau and caspase-6 that made them accessible to CHIP.
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An excreted small molecule promotes <i>C. elegans</i> reproductive development and aging

July 18th, 2019 by Andreas H. Ludewig

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0321-7

Male C. elegans excrete an N-acylated glutamine that acts via evolutionarily conserved nuclear hormone receptor and chemosensory pathways to counteract dauer diapause and accelerate sexual maturation of hermaphrodites, at the cost of shortening hermaphrodite lifespan.
  • Posted in Nat Chem Biol, Publications
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Imaging nonsense

July 18th, 2019 by Yiyun Song

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0333-3

Imaging nonsense

Pharmacological targeting of the unfolded protein response for disease intervention

July 18th, 2019 by Claudio Hetz

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0326-2

Hetz et al. discuss recent advances in the identification and optimization of small molecules targeting the unfolded protein response and the application of these small molecules in cancers, neurodegeneration and metabolic diseases.
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Covalent targeting of the vacuolar H<sup>+</sup>-ATPase activates autophagy via mTORC1 inhibition

July 8th, 2019 by Clive Yik-Sham Chung

Nature Chemical Biology, Published online: 08 July 2019; doi:10.1038/s41589-019-0308-4

A covalent ligand that targets C277 of ATP6V1A was identified resulting in enhanced v-ATPase activity, inhibition of mTORC1 signaling, increased lysosomal acidification, activation of autophagy and clearance of toxic protein aggregates.
  • Posted in Nat Chem Biol, Publications
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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

July 8th, 2019 by Jark Böttcher

Nature Chemical Biology, Published online: 08 July 2019; doi:10.1038/s41589-019-0310-x

A chemical probe BI-9321 for the PWWP1 domain of NSD3 and its inactive analog were identified. BI-9321 binds to the methyl-lysine binding site, reduces the association of NSD3 with chromatin and inhibits proliferation of acute myeloid leukemia cells.
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