Dual phenazine gene clusters enable diversification during biosynthesis

March 18th, 2019 by Yi-Ming Shi

Dual phenazine gene clusters enable diversification during biosynthesis

Dual phenazine gene clusters enable diversification during biosynthesis, Published online: 18 March 2019; doi:10.1038/s41589-019-0246-1

Enzymes from two discrete biosynthetic gene clusters in the entomopathogenic bacterium Xenorhabdus szentirmaii cooperate to produce a diverse array of phenazine natural products, including phenazine–peptide and phenazine–polyketide derivatives.
  • Posted in Nat Chem Biol, Publications
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New roles for old RNA cap flavors

March 18th, 2019 by Richard A. Padgett

New roles for old RNA cap flavors

New roles for old RNA cap flavors, Published online: 18 March 2019; doi:10.1038/s41589-019-0252-3

The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs.

Affinity selection and sequencing

March 18th, 2019 by Kit S. Lam

Affinity selection and sequencing

Affinity selection and sequencing, Published online: 18 March 2019; doi:10.1038/s41589-019-0253-2

Powerful combinatorial peptide library methods allow the discovery of peptide leads from diverse libraries. A new platform based on tandem mass spectrometry peptide sequencing coupled with high-performance size-exclusion chromatography enables identification of high-affinity peptidic ligands from focused libraries.

An appetite for aromatics

March 18th, 2019 by Mirella Bucci

An appetite for aromatics

An appetite for aromatics, Published online: 18 March 2019; doi:10.1038/s41589-019-0260-3

An appetite for aromatics

A broken heart can mend

March 18th, 2019 by Grant Miura

A broken heart can mend

A broken heart can mend, Published online: 18 March 2019; doi:10.1038/s41589-019-0259-9

A broken heart can mend

A new CRISPR scissor

March 18th, 2019 by Yiyun Song

A new CRISPR scissor

A new CRISPR scissor, Published online: 18 March 2019; doi:10.1038/s41589-019-0261-2

A new CRISPR scissor

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

March 18th, 2019 by Mehran Dastmalchi

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy, Published online: 18 March 2019; doi:10.1038/s41589-019-0247-0

Neopinone isomerase catalyzes the isomerization of the opiate alkaloid neopinone to codeinone, driving the biosynthesis of codeine and morphine and preventing accumulation of their isomers neopine and neomorphine.
  • Posted in Nat Chem Biol, Publications
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A better binder builder

March 18th, 2019 by Caitlin Deane

A better binder builder

A better binder builder, Published online: 18 March 2019; doi:10.1038/s41589-019-0258-x

A better binder builder

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

March 6th, 2019 by Jacob I Stuckey

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1, Published online: 06 March 2019; doi:10.1038/s41589-019-0242-5

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
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Potassium channel selectivity filter dynamics revealed by single-molecule FRET

March 4th, 2019 by Shizhen Wang

Potassium channel selectivity filter dynamics revealed by single-molecule FRET

Potassium channel selectivity filter dynamics revealed by single-molecule FRET, Published online: 04 March 2019; doi:10.1038/s41589-019-0240-7

Single-molecule FRET shows that a loop, which forms the selectivity filter in the bacterial inwardly rectifying K+ channel KirBac1.1, transitions between constrained and dilated conformations depending on ion occupancy of the filter.
  • Posted in Nat Chem Biol, Publications
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