Publisher Correction: Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase family
June 25th, 2020 by Camila R. Santos
Nature Chemical Biology, Published online: 25 June 2020; doi:10.1038/s41589-020-0590-1
Publisher Correction: Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase familyGroovy RNA polymerase
June 22nd, 2020 by Mirella Bucci
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0582-1
Groovy RNA polymeraseDissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors
June 22nd, 2020 by Pabitra K. Parua
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0563-4
This Review provides insights into transcriptional regulation, and vulnerabilities of cancer cells to disruption of cyclin-dependent kinase (CDK)-mediated regulation of Pol II transcription, revealed with small-molecule CDK inhibitors.Structural insight into the formation of lipoprotein-β-barrel complexes
June 22nd, 2020 by Raquel Rodríguez-Alonso
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0575-0
A structural and biochemical study of bacterial β-barrel assembly machinery component BamA with transport substrate RcsF shows an inward-open conformation with RcsF trapped inside the β-barrel lumen and suggests a push–pull substrate export mechanism.Spectroscopic coherent Raman imaging of <i>Caenorhabditis elegans</i> reveals lipid particle diversity
June 22nd, 2020 by Wei-Wen Chen
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0565-2
A Raman-based imaging approach that can distinguish closely related chemical species used to characterize the distribution of lipids throughout the body of intact Caenorhabditis elegans worms shows that the epidermis is an important fat-storage reservoir.Discovering Nature’s super glue
June 22nd, 2020 by Zhi Zeng
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0586-x
Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.Taking out the trash
June 22nd, 2020 by Grant Miura
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0581-2
Taking out the trashThe uninhibited pathway is not worth studying
June 22nd, 2020 by Michael E. Pacold
Nature Chemical Biology, Published online: 22 June 2020; doi:10.1038/s41589-020-0562-5
Glucose 6-phosphate dehydrogenase (G6PD) stands at the head of the pentose phosphate pathway, which is responsible for nucleotide synthesis. The identification and thorough validation of an improved G6PD inhibitor provide a valuable new tool compound for studying metabolism.Enzymes knuckle down to the job
June 17th, 2020 by Paul H. Walton
Nature Chemical Biology, Published online: 17 June 2020; doi:10.1038/s41589-020-0585-y
A suite of new enzymes reveals more on how Nature breaks down plant-based polysaccharides and how these enzymes might be harnessed in the utilization of plant-based biomass.Unraveling proteasome engagement
June 15th, 2020 by Cameron G. Roberts
Nature Chemical Biology, Published online: 15 June 2020; doi:10.1038/s41589-020-0573-2
A new study reveals that, in addition to its longstanding role in recruiting proteins to the proteasome, ubiquitination can also induce a structural destabilization that allows the target protein to be efficiently unraveled for degradation.