A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

April 6th, 2014 by Polina Prusevich, Jay H. Kalin, Shonoi A. Ming, Manuela Basso, Jeffrey Givens, Xin Li, Jianfei Hu, Martin S. Taylor, Anne M. Cieniewicz, Po-Yuan Hsiao, Rong Huang, Heather Roberson, Nkosi Adejola, Lindsay B. Avery, Robert A. Casero, Sean D. Taverna,

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ACS Chemical Biology
DOI: 10.1021/cb500018s

X-ray Structures of Human Furin in Complex with Competitive Inhibitors

April 1st, 2014 by Sven O. Dahms, Kornelia Hardes, Gero L. Becker, Torsten Steinmetzer, Hans Brandstetter and Manuel E. Than

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ACS Chemical Biology
DOI: 10.1021/cb500087x

Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents

March 31st, 2014 by John Gilchrist, Stacey Dutton, Marcelo Diaz-Bustamante, Annie McPherson, Nicolas Olivares, Jeet Kalia, Andrew Escayg and Frank Bosmans

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ACS Chemical Biology
DOI: 10.1021/cb500108p

Identification and Characterization of an Allosteric Inhibitory Site on Dihydropteroate Synthase

March 27th, 2014 by Dalia I. Hammoudeh, Mihir DateĢ, Mi-Kyung Yun, Weixing Zhang, Vincent A. Boyd, Ariele Viacava Follis, Elizabeth Griffith, Richard E. Lee, Donald Bashford and Stephen W. White

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ACS Chemical Biology
DOI: 10.1021/cb500038g

Expanded Cellular Amino Acid Pools Containing Phosphoserine, Phosphothreonine, and Phosphotyrosine

March 27th, 2014 by Justin B. Steinfeld, Hans R. Aerni, Svetlana Rogulina, Yuchen Liu and Jesse Rinehart

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ACS Chemical Biology
DOI: 10.1021/cb5000532
  • Posted in ACS Chemical Biology, Publications
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Synthetic RNA Recognition Motifs That Selectively Recognize HIV-1 Trans-Activation Response Element Hairpin RNA

March 25th, 2014 by Brett D. Blakeley and Brian R. McNaughton

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ACS Chemical Biology
DOI: 10.1021/cb500138h
  • Posted in ACS Chemical Biology, Publications
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Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

March 25th, 2014 by Rakesh K. Pathak, Sean Marrache, Donald A. Harn and Shanta Dhar

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ACS Chemical Biology
DOI: 10.1021/cb400944y
  • Posted in ACS Chemical Biology, Publications
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Optical Control of the Ca2+ Concentration in a Live Specimen with a Genetically Encoded Ca2+-Releasing Molecular Tool

March 24th, 2014 by Noritaka Fukuda, Tomoki Matsuda and Takeharu Nagai

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ACS Chemical Biology
DOI: 10.1021/cb400849n
  • Posted in ACS Chemical Biology, Publications
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A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

March 24th, 2014 by Wei Huang, Zizheng Dong, Fang Wang, Hui Peng, Jing-Yuan Liu and Jian-Ting Zhang

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ACS Chemical Biology
DOI: 10.1021/cb500071v
  • Posted in ACS Chemical Biology, Publications
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Bright Building Blocks for Chemical Biology

March 20th, 2014 by Luke D. Lavis and Ronald T. Raines

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ACS Chemical Biology
DOI: 10.1021/cb500078u