A Chemical Strategy for the Cell-Based Detection of HDAC Activity

April 30th, 2014 by Himashinie V. K. Diyabalanage, Genevieve C. Van de Bittner, Emily L. Ricq and Jacob M. Hooker

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ACS Chemical Biology
DOI: 10.1021/cb500248r

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

April 29th, 2014 by Zheng Zhao, Hong Wu, Li Wang, Yi Liu, Stefan Knapp, Qingsong Liu and Nathanael S. Gray

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ACS Chemical Biology
DOI: 10.1021/cb500129t
  • Posted in ACS Chemical Biology, Publications
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Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps

April 28th, 2014 by Ying Zhang, Yu-Chung E. Chang, John M. Louis, Yuan-Fang Wang, Robert W. Harrison and Irene T. Weber

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ACS Chemical Biology
DOI: 10.1021/cb4008875
  • Posted in ACS Chemical Biology, Publications
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Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness

April 28th, 2014 by Daniel I. Benjamin, Sharon M. Louie, Melinda M. Mulvihill, Rebecca A. Kohnz, Daniel S. Li, Lauryn G. Chan, Antonio Sorrentino, Sourav Bandyopadhyay, Alyssa Cozzo, Anayo Ohiri, Andrei Goga, Shu-Wing Ng and Daniel K. Nomura

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ACS Chemical Biology
DOI: 10.1021/cb5001907
  • Posted in ACS Chemical Biology, Publications
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Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology

April 22nd, 2014 by Manohary Rajendram, Katherine A. Hurley, Marie H. Foss, Kelsey M. Thornton, Jared T. Moore, Jared T. Shaw and Douglas B. Weibel

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ACS Chemical Biology
DOI: 10.1021/cb500154m

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

April 16th, 2014 by Lisa M. Ryno, Joseph C. Genereux, Tadasuke Naito, Richard I. Morimoto, Evan T. Powers, Matthew D. Shoulders and R. Luke Wiseman

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ACS Chemical Biology
DOI: 10.1021/cb500062n
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Correction to Mutasynthesis of a Potent Anticancer Sibiromycin Analogue

April 14th, 2014 by Isaac T. Yonemoto, Wei Li, Ankush Khullar, Natàlia Reixach and Barbara Gerratana

ACS Chemical Biology
DOI: 10.1021/cb5002476

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

April 10th, 2014 by Aude Echalier, Alison J. Hole, Graziano Lolli, Jane A. Endicott and Martin E. M. Noble

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ACS Chemical Biology
DOI: 10.1021/cb500135f

Noncovalent Spin Labeling of Riboswitch RNAs To Obtain Long-Range Structural NMR Restraints

April 9th, 2014 by Christina Helmling, Irene Bessi, Anna Wacker, Kai A. Schnorr, Hendrik R. A. Jonker, Christian Richter, Dominic Wagner, Michael Kreibich and Harald Schwalbe

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ACS Chemical Biology
DOI: 10.1021/cb500050t

Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNAPro

April 9th, 2014 by Jinfan Wang, Marek Kwiatkowski, Michael Y. Pavlov, Måns Ehrenberg and Anthony C. Forster

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ACS Chemical Biology
DOI: 10.1021/cb500036a