Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth

May 5th, 2014 by Qian Wang, Tanja Grkovic, Josep Font, Sarah Bonham, Rebecca H Pouwer, Charles G Bailey, Anne M Moran, Renae M Ryan, John EJ Rasko, Mika Jormakka, Ronald J Quinn and Jeff Holst

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ACS Chemical Biology
DOI: 10.1021/cb500120x
  • Posted in ACS Chemical Biology, Publications
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Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies

May 1st, 2014 by Michelle Pirruccello, Ramiro Nandez, Olof Idevall-Hagren, Abel Alcazar-Roman, Laura Abriola, Shana Alexandra Berwick, Louise Lucast, Dayna Morel and Pietro De Camilli

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ACS Chemical Biology
DOI: 10.1021/cb500161z

Directing the Immune System with Chemical Compounds

April 30th, 2014 by Rock J. Mancini, Lalisa Stutts, Keun Ah Ryu, Janine K. Tom and Aaron P. Esser-Kahn

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ACS Chemical Biology
DOI: 10.1021/cb500079s

Arixanthomycins A–C: Phylogeny-Guided Discovery of Biologically Active eDNA-Derived Pentangular Polyphenols

April 30th, 2014 by Hahk-Soo Kang and Sean F. Brady

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ACS Chemical Biology
DOI: 10.1021/cb500141b
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Correction to Identification and Validation of Cryptochrome Inhibitors That Modulate the Molecular Circadian Clock

April 30th, 2014 by Kyungjin Kim and Young-Ger Suh

ACS Chemical Biology
DOI: 10.1021/cb5002872
  • Posted in ACS Chemical Biology, Publications
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A Chemical Strategy for the Cell-Based Detection of HDAC Activity

April 30th, 2014 by Himashinie V. K. Diyabalanage, Genevieve C. Van de Bittner, Emily L. Ricq and Jacob M. Hooker

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ACS Chemical Biology
DOI: 10.1021/cb500248r

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

April 29th, 2014 by Zheng Zhao, Hong Wu, Li Wang, Yi Liu, Stefan Knapp, Qingsong Liu and Nathanael S. Gray

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ACS Chemical Biology
DOI: 10.1021/cb500129t
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Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps

April 28th, 2014 by Ying Zhang, Yu-Chung E. Chang, John M. Louis, Yuan-Fang Wang, Robert W. Harrison and Irene T. Weber

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ACS Chemical Biology
DOI: 10.1021/cb4008875
  • Posted in ACS Chemical Biology, Publications
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Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness

April 28th, 2014 by Daniel I. Benjamin, Sharon M. Louie, Melinda M. Mulvihill, Rebecca A. Kohnz, Daniel S. Li, Lauryn G. Chan, Antonio Sorrentino, Sourav Bandyopadhyay, Alyssa Cozzo, Anayo Ohiri, Andrei Goga, Shu-Wing Ng and Daniel K. Nomura

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ACS Chemical Biology
DOI: 10.1021/cb5001907
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Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology

April 22nd, 2014 by Manohary Rajendram, Katherine A. Hurley, Marie H. Foss, Kelsey M. Thornton, Jared T. Moore, Jared T. Shaw and Douglas B. Weibel

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ACS Chemical Biology
DOI: 10.1021/cb500154m