Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System

May 15th, 2014 by Andrea Chicca, Diego Caprioglio, Alberto Minassi, Vanessa Petrucci, Giovanni Appendino, Orazio Taglialatela-Scafati and Jürg Gertsch

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ACS Chemical Biology
DOI: 10.1021/cb500177c
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A Biosensor of Src Family Kinase Conformation by Exposable Tetracysteine Useful for Cell-Based Screening

May 15th, 2014 by Sevgi Irtegun, Rebecca Wood, Kurt Lackovic, Jörg Schweiggert, Yasmin M. Ramdzan, David C. S. Huang, Terrence D. Mulhern and Danny M. Hatters

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ACS Chemical Biology
DOI: 10.1021/cb500242q
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Role of N-Linked Glycans in the Interactions of Recombinant HCV Envelope Glycoproteins with Cellular Receptors

May 15th, 2014 by Po-Chang Chen, Po-Kai Chuang, Chein-Hung Chen, Ya-Ting Chan, Juine-Ruey Chen, Sheng-Wei Lin, Che Ma, Tsui-Ling Hsu and Chi-Huey Wong

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ACS Chemical Biology
DOI: 10.1021/cb500121c
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Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases

May 15th, 2014 by Avanika Mahajan, Dipak Barua, Patrick Cutler, Diane S. Lidke, Flor A. Espinoza, Carolyn Pehlke, Rachel Grattan, Yuko Kawakami, Chang-Shung Tung, Andrew R. M. Bradbury, William S. Hlavacek and Bridget S. Wilson

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ACS Chemical Biology
DOI: 10.1021/cb500134t
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Evaluating the Promiscuous Nature of Tyrosine Kinase Inhibitors Assessed in A431 Epidermoid Carcinoma Cells by Both Chemical- and Phosphoproteomics

May 14th, 2014 by Piero Giansanti, Christian Preisinger, Kilian V. M. Huber, Manuela Gridling, Giulio Superti-Furga, Keiryn L. Bennett and Albert J. R. Heck

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ACS Chemical Biology
DOI: 10.1021/cb500116c
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Correction to Robust Red FRET Sensors Using Self-Associating Fluorescent Domains

May 14th, 2014 by Laurens H. Lindenburg, Anne M. Hessels, Eduard H. T. M. Ebberink, Remco Arts and Maarten Merkx

ACS Chemical Biology
DOI: 10.1021/cb500291b

Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

May 13th, 2014 by Francesca Magnani, Charalampos G. Pappas, Tim Crook, Vassiliki Magafa, Paul Cordopatis, Susumu Ishiguro, Naomi Ohta, Jana Selent, Sanja Bosnyak, Emma S. Jones, Ioannis P. Gerothanassis, Masaaki Tamura, Robert E. Widdop and Andreas G. Tzakos

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ACS Chemical Biology
DOI: 10.1021/cb500063y

Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human α-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants

May 12th, 2014 by Yi Yu, Teresa Mena-Barragán, Katsumi Higaki, Jennifer L. Johnson, Jason E. Drury, Raquel L. Lieberman, Naoe Nakasone, Haruaki Ninomiya, Takahiro Tsukimura, Hitoshi Sakuraba, Yoshiyuki Suzuki, Eiji Nanba, Carmen Ortiz Mellet, José M. García Fernán

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ACS Chemical Biology
DOI: 10.1021/cb500143h
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Rapid Kinetic Characterization of Glycosyl Hydrolases Based on Oxime Derivatization and Nanostructure-Initiator Mass Spectrometry (NIMS)

May 12th, 2014 by Kai Deng, Taichi E. Takasuka, Richard Heins, Xiaoliang Cheng, Lai F. Bergeman, Jian Shi, Ryan Aschenbrener, Sam Deutsch, Seema Singh, Kenneth L. Sale, Blake A. Simmons, Paul D. Adams, Anup K. Singh, Brian G. Fox and Trent R. Northen

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ACS Chemical Biology
DOI: 10.1021/cb5000289
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Unnatural Amino Acid Mutagenesis Reveals Dimerization As a Negative Regulatory Mechanism of VHR’s Phosphatase Activity

May 9th, 2014 by Karolina Pavic, Pablo Rios, Kristina Dzeyk, Christine Koehler, Edward A. Lemke and Maja Köhn

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ACS Chemical Biology
DOI: 10.1021/cb500240n
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