Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases

May 15th, 2014 by Avanika Mahajan, Dipak Barua, Patrick Cutler, Diane S. Lidke, Flor A. Espinoza, Carolyn Pehlke, Rachel Grattan, Yuko Kawakami, Chang-Shung Tung, Andrew R. M. Bradbury, William S. Hlavacek and Bridget S. Wilson

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ACS Chemical Biology
DOI: 10.1021/cb500134t
  • Posted in ACS Chemical Biology, Publications
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Evaluating the Promiscuous Nature of Tyrosine Kinase Inhibitors Assessed in A431 Epidermoid Carcinoma Cells by Both Chemical- and Phosphoproteomics

May 14th, 2014 by Piero Giansanti, Christian Preisinger, Kilian V. M. Huber, Manuela Gridling, Giulio Superti-Furga, Keiryn L. Bennett and Albert J. R. Heck

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ACS Chemical Biology
DOI: 10.1021/cb500116c
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Correction to Robust Red FRET Sensors Using Self-Associating Fluorescent Domains

May 14th, 2014 by Laurens H. Lindenburg, Anne M. Hessels, Eduard H. T. M. Ebberink, Remco Arts and Maarten Merkx

ACS Chemical Biology
DOI: 10.1021/cb500291b

Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

May 13th, 2014 by Francesca Magnani, Charalampos G. Pappas, Tim Crook, Vassiliki Magafa, Paul Cordopatis, Susumu Ishiguro, Naomi Ohta, Jana Selent, Sanja Bosnyak, Emma S. Jones, Ioannis P. Gerothanassis, Masaaki Tamura, Robert E. Widdop and Andreas G. Tzakos

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ACS Chemical Biology
DOI: 10.1021/cb500063y

Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human α-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants

May 12th, 2014 by Yi Yu, Teresa Mena-Barragán, Katsumi Higaki, Jennifer L. Johnson, Jason E. Drury, Raquel L. Lieberman, Naoe Nakasone, Haruaki Ninomiya, Takahiro Tsukimura, Hitoshi Sakuraba, Yoshiyuki Suzuki, Eiji Nanba, Carmen Ortiz Mellet, José M. García Fernán

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ACS Chemical Biology
DOI: 10.1021/cb500143h
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Rapid Kinetic Characterization of Glycosyl Hydrolases Based on Oxime Derivatization and Nanostructure-Initiator Mass Spectrometry (NIMS)

May 12th, 2014 by Kai Deng, Taichi E. Takasuka, Richard Heins, Xiaoliang Cheng, Lai F. Bergeman, Jian Shi, Ryan Aschenbrener, Sam Deutsch, Seema Singh, Kenneth L. Sale, Blake A. Simmons, Paul D. Adams, Anup K. Singh, Brian G. Fox and Trent R. Northen

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ACS Chemical Biology
DOI: 10.1021/cb5000289
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Unnatural Amino Acid Mutagenesis Reveals Dimerization As a Negative Regulatory Mechanism of VHR’s Phosphatase Activity

May 9th, 2014 by Karolina Pavic, Pablo Rios, Kristina Dzeyk, Christine Koehler, Edward A. Lemke and Maja Köhn

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ACS Chemical Biology
DOI: 10.1021/cb500240n
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Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

May 9th, 2014 by Yuxiao Wang, Tienhuei G. Ho, Daniela Bertinetti, Matthias Neddermann, Eugen Franz, Gary C. H. Mo, Lewis P. Schendowich, Avinash Sukhu, Raybun C. Spelts, Jin Zhang, Friedrich W. Herberg and Eileen J. Kennedy

ACS Chemical Biology
DOI: 10.1021/cb500329z
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Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells

May 7th, 2014 by Horst Prescher, Astrid Schweizer, Elena Kuhfeldt, Lars Nitschke and Reinhard Brossmer

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ACS Chemical Biology
DOI: 10.1021/cb400952v
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Thiamine Pyrophosphate Stimulates Acetone Activation by Desulfococcus biacutus As Monitored by a Fluorogenic ATP Analogue

May 6th, 2014 by Olga B. Gutiérrez Acosta, Norman Hardt, Stephan M. Hacker, Tobias Strittmatter, Bernhard Schink and Andreas Marx

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ACS Chemical Biology
DOI: 10.1021/cb500152y
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