Rapid Kinetic Characterization of Glycosyl Hydrolases Based on Oxime Derivatization and Nanostructure-Initiator Mass Spectrometry (NIMS)

May 12th, 2014 by Kai Deng, Taichi E. Takasuka, Richard Heins, Xiaoliang Cheng, Lai F. Bergeman, Jian Shi, Ryan Aschenbrener, Sam Deutsch, Seema Singh, Kenneth L. Sale, Blake A. Simmons, Paul D. Adams, Anup K. Singh, Brian G. Fox and Trent R. Northen

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ACS Chemical Biology
DOI: 10.1021/cb5000289
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Unnatural Amino Acid Mutagenesis Reveals Dimerization As a Negative Regulatory Mechanism of VHR’s Phosphatase Activity

May 9th, 2014 by Karolina Pavic, Pablo Rios, Kristina Dzeyk, Christine Koehler, Edward A. Lemke and Maja Köhn

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ACS Chemical Biology
DOI: 10.1021/cb500240n
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Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

May 9th, 2014 by Yuxiao Wang, Tienhuei G. Ho, Daniela Bertinetti, Matthias Neddermann, Eugen Franz, Gary C. H. Mo, Lewis P. Schendowich, Avinash Sukhu, Raybun C. Spelts, Jin Zhang, Friedrich W. Herberg and Eileen J. Kennedy

ACS Chemical Biology
DOI: 10.1021/cb500329z
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Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells

May 7th, 2014 by Horst Prescher, Astrid Schweizer, Elena Kuhfeldt, Lars Nitschke and Reinhard Brossmer

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ACS Chemical Biology
DOI: 10.1021/cb400952v
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Thiamine Pyrophosphate Stimulates Acetone Activation by Desulfococcus biacutus As Monitored by a Fluorogenic ATP Analogue

May 6th, 2014 by Olga B. Gutiérrez Acosta, Norman Hardt, Stephan M. Hacker, Tobias Strittmatter, Bernhard Schink and Andreas Marx

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ACS Chemical Biology
DOI: 10.1021/cb500152y
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Using 19F NMR to Probe Biological Interactions of Proteins and Peptides

May 6th, 2014 by E. Neil G. Marsh and Yuta Suzuki

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ACS Chemical Biology
DOI: 10.1021/cb500111u

Unique DC-SIGN Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design

May 6th, 2014 by Ieva Sutkeviciute, Michel Thépaut, Sara Sattin, Angela Berzi, John McGeagh, Sergei Grudinin, Jörg Weiser, Aline Le Roy, Jose J. Reina, Javier Rojo, Mario Clerici, Anna Bernardi, Christine Ebel and Franck Fieschi

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ACS Chemical Biology
DOI: 10.1021/cb500054h

Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth

May 5th, 2014 by Qian Wang, Tanja Grkovic, Josep Font, Sarah Bonham, Rebecca H Pouwer, Charles G Bailey, Anne M Moran, Renae M Ryan, John EJ Rasko, Mika Jormakka, Ronald J Quinn and Jeff Holst

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ACS Chemical Biology
DOI: 10.1021/cb500120x
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Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies

May 1st, 2014 by Michelle Pirruccello, Ramiro Nandez, Olof Idevall-Hagren, Abel Alcazar-Roman, Laura Abriola, Shana Alexandra Berwick, Louise Lucast, Dayna Morel and Pietro De Camilli

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ACS Chemical Biology
DOI: 10.1021/cb500161z

Directing the Immune System with Chemical Compounds

April 30th, 2014 by Rock J. Mancini, Lalisa Stutts, Keun Ah Ryu, Janine K. Tom and Aaron P. Esser-Kahn

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ACS Chemical Biology
DOI: 10.1021/cb500079s