Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

May 29th, 2014 by Angelica O. Zabala, Yit-Heng Chooi, Moon Seok Choi, Hsiao-Ching Lin and Yi Tang

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ACS Chemical Biology
DOI: 10.1021/cb500284t

Discovery of Selective Ligands for Telomeric RNA G-quadruplexes (TERRA) through 19F-NMR Based Fragment Screening

May 28th, 2014 by Miguel Garavís, Blanca López-Méndez, Alvaro Somoza, Julen Oyarzabal, Claudio Dalvit, Alfredo Villasante, Ramón Campos-Olivas and Carlos González

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ACS Chemical Biology
DOI: 10.1021/cb500100z
  • Posted in ACS Chemical Biology, Publications
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ATP-Mediated Kinome Selectivity: The Missing Link in Understanding the Contribution of Individual JAK Kinase Isoforms to Cellular Signaling

May 27th, 2014 by Atli Thorarensen, Mary Ellen Banker, Andrew Fensome, Jean-Baptiste Telliez, Brian Juba, Fabien Vincent, Robert M. Czerwinski and Agustin Casimiro-Garcia

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ACS Chemical Biology
DOI: 10.1021/cb5002125
  • Posted in ACS Chemical Biology, Publications
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Automated Genome Mining of Ribosomal Peptide Natural Products

May 23rd, 2014 by Hosein Mohimani, Roland D. Kersten, Wei-Ting Liu, Mingxun Wang, Samuel O. Purvine, Si Wu, Heather M. Brewer, Ljiljana Pasa-Tolic, Nuno Bandeira, Bradley S. Moore, Pavel A. Pevzner and Pieter C. Dorrestein

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ACS Chemical Biology
DOI: 10.1021/cb500199h

Engineering a Light-Regulated GABAA Receptor for Optical Control of Neural Inhibition

May 22nd, 2014 by Wan-Chen Lin, Christopher M. Davenport, Alexandre Mourot, Devaiah Vytla, Caleb M. Smith, Kathryne A. Medeiros, James J. Chambers and Richard H. Kramer

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ACS Chemical Biology
DOI: 10.1021/cb500167u

Synthetic versus Natural Receptors: Supramolecular Control of Chemical Sensing in Fish

May 22nd, 2014 by José P. Da Silva, Rajib Choudhury, Mintu Porel, Uwe Pischel, Steffen Jockusch, Peter C. Hubbard, Vaidhyanathan Ramamurthy and Adelino V. M. Canário

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ACS Chemical Biology
DOI: 10.1021/cb500172u

Optical Control of Protein Function through Unnatural Amino Acid Mutagenesis and Other Optogenetic Approaches

May 21st, 2014 by Austin S. Baker and Alexander Deiters

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ACS Chemical Biology
DOI: 10.1021/cb500176x
  • Posted in ACS Chemical Biology, Publications
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Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine

May 21st, 2014 by Jacqueline M. Wurst, Eric J. Drake, Jimmy R. Theriault, Ivan T. Jewett, Lynn VerPlank, Jose R. Perez, Sivaraman Dandapani, Michelle Palmer, Samuel M. Moskowitz, Stuart L. Schreiber, Benito Munoz and Andrew M. Gulick

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ACS Chemical Biology
DOI: 10.1021/cb5001586
  • Posted in ACS Chemical Biology, Publications
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Increasing Chemical Space Coverage by Combining Empirical and Computational Fragment Screens

May 20th, 2014 by Sarah Barelier, Oliv Eidam, Inbar Fish, Johan Hollander, Francis Figaroa, Ruta Nachane, John J. Irwin, Brian K. Shoichet and Gregg Siegal

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ACS Chemical Biology
DOI: 10.1021/cb5001636

Structure–Function Relationship of Thiazolide-Induced Apoptosis in Colorectal Tumor Cells

May 19th, 2014 by Anette Brockmann, Tobias Strittmatter, Sarah May, Kerstin Stemmer, Andreas Marx and Thomas Brunner

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ACS Chemical Biology
DOI: 10.1021/cb500209a