Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U-Shaped Binding Mode

July 2nd, 2014 by Jun Lu, Sangita Patel, Nandini Sharma, Stephen M. Soisson, Ryuta Kishii, Masaya Takei, Yasumichi Fukuda, Kevin J. Lumb and Sheo B. Singh

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ACS Chemical Biology
DOI: 10.1021/cb5001197
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Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors

July 2nd, 2014 by Stephen E. Leonard, A. C. Register, Ratika Krishnamurty, Gabriel J. Brighty and Dustin J. Maly

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ACS Chemical Biology
DOI: 10.1021/cb500371g
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Relative Positioning of Classical Benzodiazepines to the γ2-Subunit of GABAA Receptors

June 30th, 2014 by Simon J. Middendorp, Evelyn Hurni, Matthias Schönberger, Marco Stein, Michael Pangerl, Dirk Trauner and Erwin Sigel

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ACS Chemical Biology
DOI: 10.1021/cb500186a

Accelerated Discovery of Novel Benzodiazepine Ligands by Experiment-Guided Virtual Screening

June 27th, 2014 by Simon J. Middendorp, Roshan Puthenkalam, Roland Baur, Margot Ernst and Erwin Sigel

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ACS Chemical Biology
DOI: 10.1021/cb5001873

Membrane Environment Can Enhance the Interaction of Glycan Binding Protein to Cell Surface Glycan Receptors

June 27th, 2014 by Lei Shen, Yini Wang, Chia-I Lin, Hung-wen Liu, Athena Guo and X.-Y. Zhu

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ACS Chemical Biology
DOI: 10.1021/cb5004114
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S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation

June 27th, 2014 by Elena Butturini, Elena Darra, Giulia Chiavegato, Barbara Cellini, Flora Cozzolino, Maria Monti, Piero Pucci, Daniele Dell’Orco and Sofia Mariotto

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ACS Chemical Biology
DOI: 10.1021/cb500407d

Synthesis of Site-Specific DNA–Protein Conjugates and Their Effects on DNA Replication

June 26th, 2014 by Jung Eun Yeo, Susith Wickramaratne, Santoshkumar Khatwani, Yen-Chih Wang, Jeffrey Vervacke, Mark D. Distefano and Natalia Y. Tretyakova

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ACS Chemical Biology
DOI: 10.1021/cb5001795

Synthetic, Non-saccharide, Glycosaminoglycan Mimetics Selectively Target Colon Cancer Stem Cells

June 26th, 2014 by Nirmita J. Patel, Rajesh Karuturi, Rami A. Al-Horani, Somesh Baranwal, Jagrut Patel, Umesh R. Desai and Bhaumik B. Patel

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ACS Chemical Biology
DOI: 10.1021/cb500402f

Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2

June 26th, 2014 by Yi-Ching Li, I-Hsin Ho, Chiao-Chu Ku, Yong-Qing Zhong, Yu-Peng Hu, Zhi-Geng Chen, Chun-Yen Chen, Wei-Chen Lin, Medel Manuel L. Zulueta, Shang-Cheng Hung, Min-Guan Lin, Cheng-Chung Wang and Chwan-Deng Hsiao

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ACS Chemical Biology
DOI: 10.1021/cb500298q
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Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

June 19th, 2014 by Hao Li, Wouter A. van der Linden, Martijn Verdoes, Bogdan I. Florea, Fiona E. McAllister, Kavitha Govindaswamy, Joshua E. Elias, Purnima Bhanot, Herman S. Overkleeft and Matthew Bogyo

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ACS Chemical Biology
DOI: 10.1021/cb5001263
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