Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

July 23rd, 2014 by Glenna Wink Foight, Jeremy A. Ryan, Stefano V. Gullá, Anthony Letai and Amy E. Keating

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ACS Chemical Biology
DOI: 10.1021/cb500340w

In Situ Investigation of Mammalian Inorganic Polyphosphate Localization Using Novel Selective Fluorescent Probes JC-D7 and JC-D8

July 18th, 2014 by Plamena R. Angelova, Bikram Keshari Agrawalla, Pia A. Elustondo, Jacob Gordon, Toshikazu Shiba, Andrey Y. Abramov, Young-Tae Chang and Evgeny V. Pavlov

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ACS Chemical Biology
DOI: 10.1021/cb5000696
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Phylogenomically Guided Identification of Industrially Relevant GH1 β-Glucosidases through DNA Synthesis and Nanostructure-Initiator Mass Spectrometry

July 17th, 2014 by Richard A. Heins, Xiaoliang Cheng, Sangeeta Nath, Kai Deng, Benjamin P. Bowen, Dylan C. Chivian, Supratim Datta, Gregory D. Friedland, Patrik D’Haeseleer, Dongying Wu, Mary Tran-Gyamfi, Chessa S. Scullin, Seema Singh, Weibing Shi, Matthew G. Hamilton

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ACS Chemical Biology
DOI: 10.1021/cb500244v
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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

July 17th, 2014 by Ulrike Leurs, Brian Lohse, Kasper D. Rand, Shonoi Ming, Erik S. Riise, Philip A. Cole, Jesper L. Kristensen and Rasmus P. Clausen

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ACS Chemical Biology
DOI: 10.1021/cb500374f

Versatile Cardiac Troponin Chimera for Muscle Protein Structural Biology and Drug Discovery

July 17th, 2014 by Sandra E. Pineda-Sanabria, Olivier Julien and Brian D. Sykes

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ACS Chemical Biology
DOI: 10.1021/cb500249j

Mitochondrial and ER-Targeted eCALWY Probes Reveal High Levels of Free Zn2+

July 17th, 2014 by Pauline Chabosseau, Erkan Tuncay, Gargi Meur, Elisa A. Bellomo, Anne Hessels, Stephen Hughes, Paul R.V. Johnson, Marco Bugliani, Piero Marchetti, Belma Turan, Alexander R. Lyon, Maarten Merkx and Guy A. Rutter

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ACS Chemical Biology
DOI: 10.1021/cb5004064

Recent Advances in Radical SAM Enzymology: New Structures and Mechanisms

July 15th, 2014 by Jiarui Wang, Rory P. Woldring, Gabriel D. Román-Meléndez, Alan M. McClain, Brian R. Alzua and E. Neil G. Marsh

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ACS Chemical Biology
DOI: 10.1021/cb5004674

Genetically Encoding an Electrophilic Amino Acid for Protein Stapling and Covalent Binding to Native Receptors

July 15th, 2014 by Xiao-Hua Chen, Zheng Xiang, Ying S. Hu, Vanessa K. Lacey, Hu Cang and Lei Wang

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ACS Chemical Biology
DOI: 10.1021/cb500453a
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Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

July 14th, 2014 by Kristoff T. Homan and John J. G. Tesmer

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ACS Chemical Biology
DOI: 10.1021/cb5003976

Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs

July 14th, 2014 by Juan Pablo Maianti, Hiroki Kanazawa, Paola Dozzo, Rowena D. Matias, Lee Ann Feeney, Eliana S. Armstrong, Darin J. Hildebrandt, Timothy R. Kane, Micah J. Gliedt, Adam A. Goldblum, Martin S. Linsell, James B. Aggen, Jiro Kondo and Stephen Hanessian

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ACS Chemical Biology
DOI: 10.1021/cb5003416
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