Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition
August 10th, 2014 by Paul J. M. Jackson, Colin H. James, Terence C. Jenkins, Khondaker M. Rahman and David E. Thurston
NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes
August 7th, 2014 by Drew J. Adams, Daisuke Ito, Matthew G. Rees, Brinton Seashore-Ludlow, Xiaoling Puyang, Alex H. Ramos, Jaime H. Cheah, Paul A. Clemons, Markus Warmuth, Ping Zhu, Alykhan F. Shamji and Stuart L. Schreiber
Microbiota of Healthy Corals Are Active against Fungi in a Light-Dependent Manner
August 6th, 2014 by Wilna J. Moree, Oliver J. McConnell, Don D. Nguyen, Laura M. Sanchez, Yu-Liang Yang, Xiling Zhao, Wei-Ting Liu, Paul D. Boudreau, Jayashree Srinivasan, Librada Atencio, Javier Ballesteros, Ronnie G. Gavilán, Daniel Torres-Mendoza, Héctor M. Guzmán
Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction
August 5th, 2014 by Christopher H. Douse, Sabrina J. Maas, Jemima C. Thomas, James A. Garnett, Yunyun Sun, Ernesto Cota and Edward W. Tate
Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli
August 5th, 2014 by Shahul Hameed P, Praveena Manjrekar, Murugan Chinnapattu, Vaishali Humnabadkar, Gajanan Shanbhag, Chaitanyakumar Kedari, Naina Vinay Mudugal, Anisha Ambady, Boudewijn L.M. de Jonge, Claire Sadler, Beena Paul, Shubha Sriram, Parvinder Kaur, Supreeth G
Selective Inhibition of Initiator versus Executioner Caspases Using Small Peptides Containing Unnatural Amino Acids
August 5th, 2014 by Chris J. Vickers, Gonzalo E. González-Páez, Kevin M. Litwin, Jeffrey C. Umotoy, Evangelos A. Coutsias and Dennis W. Wolan
Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl
August 5th, 2014 by Kristina N.-M. Daeffler, Henry A. Lester and Dennis A. Dougherty
Transition-State Analysis of 2-O-Acetyl-ADP-Ribose Hydrolysis by Human Macrodomain 1
August 5th, 2014 by Brett M. Hirsch, Emmanuel S. Burgos and Vern L. Schramm
Heat-Shock Response Transcriptional Program Enables High-Yield and High-Quality Recombinant Protein Production in Escherichia coli
August 2nd, 2014 by Xin Zhang, Yu Liu, Joseph C. Genereux, Chandler Nolan, Meha Singh and Jeffery W. Kelly
Bioinspired Strategy for the Ribosomal Synthesis of Thioether-Bridged Macrocyclic Peptides in Bacteria
August 1st, 2014 by Nina Bionda, Abby L. Cryan and Rudi Fasan
