Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

August 13th, 2014 by Sherif I. Elshahawi, Theresa A. Ramelot, Jayaraman Seetharaman, Jing Chen, Shanteri Singh, Yunhuang Yang, Kari Pederson, Madan K. Kharel, Rong Xiao, Scott Lew, Ragothaman M. Yennamalli, Mitchell D. Miller, Fengbin Wang, Liang Tong, Gaetano T. Monteli

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ACS Chemical Biology
DOI: 10.1021/cb500327m
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Redesigning Human 2′-Deoxycytidine Kinase Enantioselectivity for l-Nucleoside Analogues as Reporters in Positron Emission Tomography

August 12th, 2014 by Pravin Muthu, Hannah X. Chen and Stefan Lutz

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ACS Chemical Biology
DOI: 10.1021/cb500463f
  • Posted in ACS Chemical Biology, Publications
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Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

August 11th, 2014 by Benedetta Mannini, Estefania Mulvihill, Caterina Sgromo, Roberta Cascella, Reza Khodarahmi, Matteo Ramazzotti, Christopher M. Dobson, Cristina Cecchi and Fabrizio Chiti

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ACS Chemical Biology
DOI: 10.1021/cb500505m
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An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

August 11th, 2014 by David E. Olson, Namrata D. Udeshi, Noah A. Wolfson, Carol Ann Pitcairn, Eric D. Sullivan, Jacob D. Jaffe, Tanya Svinkina, Ted Natoli, Xiaodong Liu, Joshiawa Paulk, Patrick McCarren, Florence F. Wagner, Doug Barker, Eleanor Howe, Fanny Lazzaro, Jennif

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ACS Chemical Biology
DOI: 10.1021/cb500492r

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

August 11th, 2014 by Akito Nakagawa, Francine E. Lui, Dina Wassaf, Revital Yefidoff-Freedman, Dominick Casalena, Michelle A. Palmer, Jacqueline Meadows, Andrea Mozzarelli, Luca Ronda, Osheiza Abdulmalik, Kenneth D. Bloch, Martin K. Safo and Warren M. Zapol

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ACS Chemical Biology
DOI: 10.1021/cb500230b
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Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition

August 10th, 2014 by Paul J. M. Jackson, Colin H. James, Terence C. Jenkins, Khondaker M. Rahman and David E. Thurston

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ACS Chemical Biology
DOI: 10.1021/cb5002203
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NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

August 7th, 2014 by Drew J. Adams, Daisuke Ito, Matthew G. Rees, Brinton Seashore-Ludlow, Xiaoling Puyang, Alex H. Ramos, Jaime H. Cheah, Paul A. Clemons, Markus Warmuth, Ping Zhu, Alykhan F. Shamji and Stuart L. Schreiber

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ACS Chemical Biology
DOI: 10.1021/cb500347p

Microbiota of Healthy Corals Are Active against Fungi in a Light-Dependent Manner

August 6th, 2014 by Wilna J. Moree, Oliver J. McConnell, Don D. Nguyen, Laura M. Sanchez, Yu-Liang Yang, Xiling Zhao, Wei-Ting Liu, Paul D. Boudreau, Jayashree Srinivasan, Librada Atencio, Javier Ballesteros, Ronnie G. Gavilán, Daniel Torres-Mendoza, Héctor M. Guzmán

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ACS Chemical Biology
DOI: 10.1021/cb500432j

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

August 5th, 2014 by Christopher H. Douse, Sabrina J. Maas, Jemima C. Thomas, James A. Garnett, Yunyun Sun, Ernesto Cota and Edward W. Tate

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ACS Chemical Biology
DOI: 10.1021/cb500271c
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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

August 5th, 2014 by Shahul Hameed P, Praveena Manjrekar, Murugan Chinnapattu, Vaishali Humnabadkar, Gajanan Shanbhag, Chaitanyakumar Kedari, Naina Vinay Mudugal, Anisha Ambady, Boudewijn L.M. de Jonge, Claire Sadler, Beena Paul, Shubha Sriram, Parvinder Kaur, Supreeth G

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ACS Chemical Biology
DOI: 10.1021/cb500360c
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