Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition

August 10th, 2014 by Paul J. M. Jackson, Colin H. James, Terence C. Jenkins, Khondaker M. Rahman and David E. Thurston

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ACS Chemical Biology
DOI: 10.1021/cb5002203
  • Posted in ACS Chemical Biology, Publications
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NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

August 7th, 2014 by Drew J. Adams, Daisuke Ito, Matthew G. Rees, Brinton Seashore-Ludlow, Xiaoling Puyang, Alex H. Ramos, Jaime H. Cheah, Paul A. Clemons, Markus Warmuth, Ping Zhu, Alykhan F. Shamji and Stuart L. Schreiber

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ACS Chemical Biology
DOI: 10.1021/cb500347p

Microbiota of Healthy Corals Are Active against Fungi in a Light-Dependent Manner

August 6th, 2014 by Wilna J. Moree, Oliver J. McConnell, Don D. Nguyen, Laura M. Sanchez, Yu-Liang Yang, Xiling Zhao, Wei-Ting Liu, Paul D. Boudreau, Jayashree Srinivasan, Librada Atencio, Javier Ballesteros, Ronnie G. Gavilán, Daniel Torres-Mendoza, Héctor M. Guzmán

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ACS Chemical Biology
DOI: 10.1021/cb500432j

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

August 5th, 2014 by Christopher H. Douse, Sabrina J. Maas, Jemima C. Thomas, James A. Garnett, Yunyun Sun, Ernesto Cota and Edward W. Tate

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ACS Chemical Biology
DOI: 10.1021/cb500271c
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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

August 5th, 2014 by Shahul Hameed P, Praveena Manjrekar, Murugan Chinnapattu, Vaishali Humnabadkar, Gajanan Shanbhag, Chaitanyakumar Kedari, Naina Vinay Mudugal, Anisha Ambady, Boudewijn L.M. de Jonge, Claire Sadler, Beena Paul, Shubha Sriram, Parvinder Kaur, Supreeth G

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ACS Chemical Biology
DOI: 10.1021/cb500360c
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Selective Inhibition of Initiator versus Executioner Caspases Using Small Peptides Containing Unnatural Amino Acids

August 5th, 2014 by Chris J. Vickers, Gonzalo E. González-Páez, Kevin M. Litwin, Jeffrey C. Umotoy, Evangelos A. Coutsias and Dennis W. Wolan

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ACS Chemical Biology
DOI: 10.1021/cb5004256
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Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl

August 5th, 2014 by Kristina N.-M. Daeffler, Henry A. Lester and Dennis A. Dougherty

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ACS Chemical Biology
DOI: 10.1021/cb500323d
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Transition-State Analysis of 2-O-Acetyl-ADP-Ribose Hydrolysis by Human Macrodomain 1

August 5th, 2014 by Brett M. Hirsch, Emmanuel S. Burgos and Vern L. Schramm

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ACS Chemical Biology
DOI: 10.1021/cb500485w

Heat-Shock Response Transcriptional Program Enables High-Yield and High-Quality Recombinant Protein Production in Escherichia coli

August 2nd, 2014 by Xin Zhang, Yu Liu, Joseph C. Genereux, Chandler Nolan, Meha Singh and Jeffery W. Kelly

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ACS Chemical Biology
DOI: 10.1021/cb5004477
  • Posted in ACS Chemical Biology, Publications
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Bioinspired Strategy for the Ribosomal Synthesis of Thioether-Bridged Macrocyclic Peptides in Bacteria

August 1st, 2014 by Nina Bionda, Abby L. Cryan and Rudi Fasan

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ACS Chemical Biology
DOI: 10.1021/cb500311k
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