Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

August 28th, 2014 by Julia I-Ju Leu, Pingfeng Zhang, Maureen E. Murphy, Ronen Marmorstein and Donna L. George

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ACS Chemical Biology
DOI: 10.1021/cb500236y
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Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2

August 28th, 2014 by Brooke M. Swalm, Sarah K. Knutson, Natalie M. Warholic, Lei Jin, Kevin W. Kuntz, Heike Keilhack, Jesse J. Smith, Roy M. Pollock, Mikel P. Moyer, Margaret Porter Scott, Robert A. Copeland and Tim J. Wigle

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ACS Chemical Biology
DOI: 10.1021/cb500548b

N-Terminal Phosphorylation of Parathyroid Hormone (PTH) Abolishes Its Receptor Activity

August 28th, 2014 by Amit Kumar, Mohanraj Gopalswamy, Clare Wishart, Mathias Henze, Lennart Eschen-Lippold, Dan Donnelly and Jochen Balbach

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ACS Chemical Biology
DOI: 10.1021/cb5004515

Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

August 28th, 2014 by Hyekyung P. Cho, Pedro M. Garcia-Barrantes, John T. Brogan, Corey R. Hopkins, Colleen M. Niswender, Alice L. Rodriguez, Daryl F. Venable, Ryan D. Morrison, Michael Bubser, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn and Craig W. Lindsley

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ACS Chemical Biology
DOI: 10.1021/cb500560h
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Boron Dipyrromethene As a Fluorescent Caging Group for Single-Photon Uncaging with Long-Wavelength Visible Light

August 27th, 2014 by Nobuhiro Umeda, Hironori Takahashi, Mako Kamiya, Tasuku Ueno, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano and Yasuteru Urano

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ACS Chemical Biology
DOI: 10.1021/cb500525p
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Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge

August 26th, 2014 by Gang Chen, Jayne F. Koellhoffer, Samantha E. Zak, Julia C. Frei, Nina Liu, Hua Long, Wei Ye, Kaajal Nagar, Guohua Pan, Kartik Chandran, John M. Dye, Sachdev S. Sidhu and Jonathan R. Lai

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ACS Chemical Biology
DOI: 10.1021/cb5006454
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Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

August 24th, 2014 by Anna Leonidova and Gilles Gasser

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ACS Chemical Biology
DOI: 10.1021/cb500528c

Simultaneous Detection of Distinct Ubiquitin Chain Topologies by 19F NMR

August 22nd, 2014 by Sujan S. Shekhawat, Grace H. Pham, Jyothiprashanth Prabakaran and Eric R. Strieter

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ACS Chemical Biology
DOI: 10.1021/cb500589c

Labeled EF-Tus for Rapid Kinetic Studies of Pretranslocation Complex Formation

August 22nd, 2014 by Wei Liu, Darius Kavaliauskas, Jared M. Schrader, Kiran Poruri, Victoria Birkedal, Emanuel Goldman, Hieronim Jakubowski, Wlodek Mandecki, Olke C. Uhlenbeck, Charlotte R. Knudsen, Yale E. Goldman and Barry S. Cooperman

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ACS Chemical Biology
DOI: 10.1021/cb500409y

High-Throughput Screening System To Identify Small Molecules That Induce Internalization and Degradation of HER2

August 22nd, 2014 by Masayuki Isa, Daisuke Asanuma, Shigeyuki Namiki, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano and Kenzo Hirose

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ACS Chemical Biology
DOI: 10.1021/cb500654q
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