Small-Molecule Inhibitors of SETD8 with Cellular Activity

September 3rd, 2014 by Gil Blum, Glorymar Ibáñez, Xiangjun Rao, David Shum, Constantin Radu, Hakim Djaballah, Judd C. Rice and Minkui Luo

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ACS Chemical Biology
DOI: 10.1021/cb500515r

Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein

September 2nd, 2014 by Rahul Patil, Aisha Laguerre, Jerome Wielens, Stephen J. Headey, Martin L. Williams, Maria L. R. Hughes, Biswaranjan Mohanty, Christopher J. H. Porter and Martin J. Scanlon

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ACS Chemical Biology
DOI: 10.1021/cb5005178
  • Posted in ACS Chemical Biology, Publications
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Loop Electrostatics Modulates the Intersubunit Interactions in Ferritin

August 29th, 2014 by Caterina Bernacchioni, Veronica Ghini, Cecilia Pozzi, Flavio Di Pisa, Elizabeth C. Theil and Paola Turano

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ACS Chemical Biology
DOI: 10.1021/cb500431r

Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

August 28th, 2014 by Julia I-Ju Leu, Pingfeng Zhang, Maureen E. Murphy, Ronen Marmorstein and Donna L. George

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ACS Chemical Biology
DOI: 10.1021/cb500236y
  • Posted in ACS Chemical Biology, Publications
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Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2

August 28th, 2014 by Brooke M. Swalm, Sarah K. Knutson, Natalie M. Warholic, Lei Jin, Kevin W. Kuntz, Heike Keilhack, Jesse J. Smith, Roy M. Pollock, Mikel P. Moyer, Margaret Porter Scott, Robert A. Copeland and Tim J. Wigle

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ACS Chemical Biology
DOI: 10.1021/cb500548b

N-Terminal Phosphorylation of Parathyroid Hormone (PTH) Abolishes Its Receptor Activity

August 28th, 2014 by Amit Kumar, Mohanraj Gopalswamy, Clare Wishart, Mathias Henze, Lennart Eschen-Lippold, Dan Donnelly and Jochen Balbach

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ACS Chemical Biology
DOI: 10.1021/cb5004515

Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

August 28th, 2014 by Hyekyung P. Cho, Pedro M. Garcia-Barrantes, John T. Brogan, Corey R. Hopkins, Colleen M. Niswender, Alice L. Rodriguez, Daryl F. Venable, Ryan D. Morrison, Michael Bubser, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn and Craig W. Lindsley

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ACS Chemical Biology
DOI: 10.1021/cb500560h
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Boron Dipyrromethene As a Fluorescent Caging Group for Single-Photon Uncaging with Long-Wavelength Visible Light

August 27th, 2014 by Nobuhiro Umeda, Hironori Takahashi, Mako Kamiya, Tasuku Ueno, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano and Yasuteru Urano

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ACS Chemical Biology
DOI: 10.1021/cb500525p
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Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge

August 26th, 2014 by Gang Chen, Jayne F. Koellhoffer, Samantha E. Zak, Julia C. Frei, Nina Liu, Hua Long, Wei Ye, Kaajal Nagar, Guohua Pan, Kartik Chandran, John M. Dye, Sachdev S. Sidhu and Jonathan R. Lai

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ACS Chemical Biology
DOI: 10.1021/cb5006454
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Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

August 24th, 2014 by Anna Leonidova and Gilles Gasser

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ACS Chemical Biology
DOI: 10.1021/cb500528c