Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates

October 20th, 2014 by Whitney C. Duim, Yan Jiang, Koning Shen, Judith Frydman and W. E. Moerner

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ACS Chemical Biology
DOI: 10.1021/cb500335w
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Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes

October 20th, 2014 by Evgeny Kiselev, Matthew O. Barrett, Vsevolod Katritch, Silvia Paoletta, Clarissa D. Weitzer, Kyle A. Brown, Eva Hammes, Andrew L. Yin, Qiang Zhao, Raymond C. Stevens, T. Kendall Harden and Kenneth A. Jacobson

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ACS Chemical Biology
DOI: 10.1021/cb500614p
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Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment

October 19th, 2014 by Jan-Philip Schülke, Laura A. McAllister, Kieran F. Geoghegan, Vinod Parikh, Thomas A. Chappie, Patrick R. Verhoest, Christopher J. Schmidt, Douglas S. Johnson and Nicholas J. Brandon

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ACS Chemical Biology
DOI: 10.1021/cb500671j
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Evolved Sequence Contexts for Highly Efficient Amber Suppression with Noncanonical Amino Acids

October 16th, 2014 by Moritz Pott, Moritz Johannes Schmidt and Daniel Summerer

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ACS Chemical Biology
DOI: 10.1021/cb5006273

Identification of Small Molecules That Protect Pancreatic β Cells against Endoplasmic Reticulum Stress-Induced Cell Death

October 16th, 2014 by Kim Tran, Yu Li, Hongliang Duan, Daleep Arora, Hui-Ying Lim and Weidong Wang

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ACS Chemical Biology
DOI: 10.1021/cb500740d
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O6-Alkylguanine Postlesion DNA Synthesis Is Correct with the Right Complement of Hydrogen Bonding

October 15th, 2014 by Hailey L. Gahlon, Melissa L. Boby and Shana J. Sturla

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ACS Chemical Biology
DOI: 10.1021/cb500415q
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Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor

October 13th, 2014 by Ilaria Lamberto, Bernhard C. Lechtenberg, Erika J. Olson, Peter D. Mace, Philip E. Dawson, Stefan J. Riedl and Elena B. Pasquale

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ACS Chemical Biology
DOI: 10.1021/cb500677x
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Inhibition of the Ferric Uptake Regulator by Peptides Derived from Anti-FUR Peptide Aptamers: Coupled Theoretical and Experimental Approaches

October 9th, 2014 by Cheickna Cissé, Sophie V. Mathieu, Mohamed B. Ould Abeih, Lindsey Flanagan, Sylvia Vitale, Patrice Catty, Didier Boturyn, Isabelle Michaud-Soret and Serge Crouzy

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ACS Chemical Biology
DOI: 10.1021/cb5005977
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Direct Binding of Bcl-2 Family Proteins by Quercetin Triggers Its Pro-Apoptotic Activity

October 9th, 2014 by Alexandra Primikyri, Maria V. Chatziathanasiadou, Evdoxia Karali, Eleftherios Kostaras, Michalis D. Mantzaris, Eleftheria Hatzimichael, Jae-Sun Shin, Seung-Wook Chi, Evangelos Briasoulis, Evangelos Kolettas, Ioannis P. Gerothanassis and Andreas G. Tz

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ACS Chemical Biology
DOI: 10.1021/cb500259e

Designed Phosphoprotein Recognition in Escherichia coli

October 5th, 2014 by Nicholas Sawyer, Brandon M. Gassaway, Adrian D. Haimovich, Farren J. Isaacs, Jesse Rinehart and Lynne Regan

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ACS Chemical Biology
DOI: 10.1021/cb500658w