Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

December 4th, 2014 by Sushmita D. Lahiri, Stefano Mangani, Haris Jahić, Manuela Benvenuti, Thomas F. Durand-Reville, Filomena De Luca, David E. Ehmann, Gian Maria Rossolini, Richard A Alm and Jean-Denis Docquier

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ACS Chemical Biology
DOI: 10.1021/cb500703p
  • Posted in ACS Chemical Biology, Publications
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Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells

December 3rd, 2014 by Suman Ghosh, Heather E. Shinogle, Gaurav Garg, George A. Vielhauer, Jeffrey M. Holzbeierlein, Rick T. Dobrowsky and Brian S. J. Blagg

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ACS Chemical Biology
DOI: 10.1021/cb5008713
  • Posted in ACS Chemical Biology, Publications
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Inhibition of CDC25B Phosphatase Through Disruption of Protein–Protein Interaction

December 1st, 2014 by George Lund, Sergii Dudkin, Dmitry Borkin, Wendi Ni, Jolanta Grembecka and Tomasz Cierpicki

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ACS Chemical Biology
DOI: 10.1021/cb500883h

Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics

December 1st, 2014 by J. Matthew Meinig and Blake R. Peterson

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ACS Chemical Biology
DOI: 10.1021/cb500856c
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Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A

November 26th, 2014 by Joachim Braun, Martin M. Möckel, Tobias Strittmatter, Andreas Marx, Ulrich Groth and Thomas U. Mayer

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ACS Chemical Biology
DOI: 10.1021/cb500789h

Cardiac Glycoside Activities Link Na+/K+ ATPase Ion-Transport to Breast Cancer Cell Migration via Correlative SAR

November 26th, 2014 by Anniefer N. Magpusao, George Omolloh, Joshua Johnson, José Gascón, Mark W. Peczuh and Gabriel Fenteany

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ACS Chemical Biology
DOI: 10.1021/cb500665r
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Chemical Probes of Histone Lysine Methyltransferases

November 25th, 2014 by H. Ümit Kaniskan and Jian Jin

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ACS Chemical Biology
DOI: 10.1021/cb500785t

Correction to Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli

November 24th, 2014 by Anubrata Ghosal, Ally Vitali, James E. M. Stach and Peter E. Nielsen

ACS Chemical Biology
DOI: 10.1021/cb500900g
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An Evolved Mxe GyrA Intein for Enhanced Production of Fusion Proteins

November 24th, 2014 by Carrie J. Marshall, Vanessa A. Grosskopf, Taylor J. Moehling, Benjamin J. Tillotson, Gregory J. Wiepz, Nicholas L. Abbott, Ronald T. Raines and Eric V. Shusta

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ACS Chemical Biology
DOI: 10.1021/cb500689g

Sequence-Specific Generation of 1,N6-Ethenoadenine and 3,N4-Ethenocytosine in Single-Stranded Unmodified DNA

November 24th, 2014 by David Egloff, Igor A. Oleinich and Eva Freisinger

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ACS Chemical Biology
DOI: 10.1021/cb500497p
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