Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications

December 8th, 2014 by Charuta C. Palsuledesai and Mark D. Distefano

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500791f

Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

December 8th, 2014 by Yoshiki Yamaryo-Botte, Arek K. Rainczuk, David J. Lea-Smith, Rajini Brammananth, Phillip L. van der Peet, Peter Meikle, Julie E. Ralton, Thusita W. T. Rupasinghe, Spencer J. Williams, Ross L. Coppel, Paul K. Crellin and Malcolm J. McConville

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5007689
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

Directed Evolution of New and Improved Enzyme Functions Using an Evolutionary Intermediate and Multidirectional Search

December 5th, 2014 by Joanne L. Porter, Priscilla L. S. Boon, Tracy P. Murray, Thomas Huber, Charles A. Collyer and David L. Ollis

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500809f
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Directed Evolution of New and Improved Enzyme Functions Using an Evolutionary Intermediate and Multidirectional Search

Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

December 5th, 2014 by Nan Zhao, Crystal M. Darby, Jennifer Small, Daniel A. Bachovchin, Xiuju Jiang, Kristin E. Burns-Huang, Helene Botella, Sabine Ehrt, Dale L. Boger, Erin D. Anderson, Benjamin F. Cravatt, Anna E. Speers, Virneliz Fernandez-Vega, Peter S. Hodder, Christ

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500746z
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

Interfacing Chemical Biology and Drug Discovery: Report from the 50th International Conference on Medicinal Chemistry of the SCT (French Medicinal Chemistry Society), July 2–4, 2014, Rouen, France

December 5th, 2014 by Janos Sapi, Frédéric Schmidt, Luc Van Hijfte and Pascal George

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5009469
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Interfacing Chemical Biology and Drug Discovery: Report from the 50th International Conference on Medicinal Chemistry of the SCT (French Medicinal Chemistry Society), July 2–4, 2014, Rouen, France

Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity Using Multi-Target Docking

December 5th, 2014 by Denis Schmidt, Viachaslau Bernat, Regine Brox, Nuska Tschammer and Peter Kolb

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500577j
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity Using Multi-Target Docking

Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

December 5th, 2014 by Liwei Weng, Chuanzheng Zhou and Marc M. Greenberg

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500737y
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

Pseudoaeruginosins, Nonribosomal Peptides in Nodularia spumigena

December 5th, 2014 by Liwei Liu, Adnan Budnjo, Jouni Jokela, Bengt Erik Haug, David P. Fewer, Matti Wahlsten, Leo Rouhiainen, Perttu Permi, Torgils Fossen and Kaarina Sivonen

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5004306

Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis

December 4th, 2014 by Audrey Vingadassalon, Florence Lorieux, Maud Juguet, Géraldine Le Goff, Claude Gerbaud, Jean-Luc Pernodet and Sylvie Lautru

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500652n
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis

Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

December 4th, 2014 by Sushmita D. Lahiri, Stefano Mangani, Haris Jahić, Manuela Benvenuti, Thomas F. Durand-Reville, Filomena De Luca, David E. Ehmann, Gian Maria Rossolini, Richard A Alm and Jean-Denis Docquier

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500703p
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48