Pseudoaeruginosins, Nonribosomal Peptides in Nodularia spumigena

December 5th, 2014 by Liwei Liu, Adnan Budnjo, Jouni Jokela, Bengt Erik Haug, David P. Fewer, Matti Wahlsten, Leo Rouhiainen, Perttu Permi, Torgils Fossen and Kaarina Sivonen

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5004306

Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis

December 4th, 2014 by Audrey Vingadassalon, Florence Lorieux, Maud Juguet, Géraldine Le Goff, Claude Gerbaud, Jean-Luc Pernodet and Sylvie Lautru

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500652n
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis

Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

December 4th, 2014 by Sushmita D. Lahiri, Stefano Mangani, Haris Jahić, Manuela Benvenuti, Thomas F. Durand-Reville, Filomena De Luca, David E. Ehmann, Gian Maria Rossolini, Richard A Alm and Jean-Denis Docquier

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500703p
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells

December 3rd, 2014 by Suman Ghosh, Heather E. Shinogle, Gaurav Garg, George A. Vielhauer, Jeffrey M. Holzbeierlein, Rick T. Dobrowsky and Brian S. J. Blagg

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5008713
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells

Inhibition of CDC25B Phosphatase Through Disruption of Protein–Protein Interaction

December 1st, 2014 by George Lund, Sergii Dudkin, Dmitry Borkin, Wendi Ni, Jolanta Grembecka and Tomasz Cierpicki

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500883h

Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics

December 1st, 2014 by J. Matthew Meinig and Blake R. Peterson

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500856c
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics

Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A

November 26th, 2014 by Joachim Braun, Martin M. Möckel, Tobias Strittmatter, Andreas Marx, Ulrich Groth and Thomas U. Mayer

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500789h

Cardiac Glycoside Activities Link Na+/K+ ATPase Ion-Transport to Breast Cancer Cell Migration via Correlative SAR

November 26th, 2014 by Anniefer N. Magpusao, George Omolloh, Joshua Johnson, José Gascón, Mark W. Peczuh and Gabriel Fenteany

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500665r
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Cardiac Glycoside Activities Link Na+/K+ ATPase Ion-Transport to Breast Cancer Cell Migration via Correlative SAR

Chemical Probes of Histone Lysine Methyltransferases

November 25th, 2014 by H. Ümit Kaniskan and Jian Jin

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500785t

Correction to Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli

November 24th, 2014 by Anubrata Ghosal, Ally Vitali, James E. M. Stach and Peter E. Nielsen

ACS Chemical Biology
DOI: 10.1021/cb500900g
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Correction to Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli