Unexpected Off-Targets and Paradoxical Pathway Activation by Kinase Inhibitors

January 2nd, 2015 by Oliver Hantschel

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ACS Chemical Biology
DOI: 10.1021/cb500886n

Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor

January 2nd, 2015 by Jingwei Zhou, Min Li, Nanhao Chen, Shenglong Wang, Hai-Bin Luo, Yingkai Zhang and Ruibo Wu

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ACS Chemical Biology
DOI: 10.1021/cb500767c

Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

December 30th, 2014 by Marta Artola, Laura B. Ruiz-Avila, Albert Vergoñós, Sonia Huecas, Lidia Araujo-Bazán, Mar Martín-Fontecha, Henar Vázquez-Villa, Carlos Turrado, Erney Ramírez-Aportela, Annabelle Hoegl, Matthew Nodwell, Isabel Barasoain, Pablo Chacón, Stephan A

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ACS Chemical Biology
DOI: 10.1021/cb500974d

Degron Protease Blockade Sensor to Image Epigenetic Histone Protein Methylation in Cells and Living Animals

December 30th, 2014 by Thillai V. Sekar, Kira Foygel, Rammohan Devulapally and Ramasamy Paulmurugan

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ACS Chemical Biology
DOI: 10.1021/cb5008037
  • Posted in ACS Chemical Biology, Publications
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Topology Specific Stabilization of Promoter over Telomeric G-Quadruplex DNAs by Bisbenzimidazole Carboxamide Derivatives

December 26th, 2014 by V. Dhamodharan, S. Harikrishna, Achikanath C. Bhasikuttan and P. I. Pradeepkumar

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ACS Chemical Biology
DOI: 10.1021/cb5008597
  • Posted in ACS Chemical Biology, Publications
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Bacterial Histidine Kinases as Novel Antibacterial Drug Targets

December 26th, 2014 by Agnieszka E. Bem, Nadya Velikova, M. Teresa Pellicer, Peter van Baarlen, Alberto Marina and Jerry M. Wells

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ACS Chemical Biology
DOI: 10.1021/cb5007135

Classification of Chemical Chaperones Based on Their Effect on Protein Folding Landscapes

December 23rd, 2014 by Rohan Dandage, Anannya Bandyopadhyay, Gopal Gunanathan Jayaraj, Kanika Saxena, Vijit Dalal, Aritri Das and Kausik Chakraborty

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ACS Chemical Biology
DOI: 10.1021/cb500798y

Small Molecule Substrate Phosphorylation Site Inhibitors of Protein Kinases: Approaches and Challenges

December 23rd, 2014 by Meghan E. Breen and Matthew B. Soellner

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ACS Chemical Biology
DOI: 10.1021/cb5008376
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Demonstration of a Folding after Binding Mechanism in the Recognition between the Measles Virus NTAIL and X Domains

December 22nd, 2014 by Marion Dosnon, Daniela Bonetti, Angela Morrone, Jenny Erales, Eva di Silvio, Sonia Longhi and Stefano Gianni

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ACS Chemical Biology
DOI: 10.1021/cb5008579
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Structure-Based Design of a B Cell Antigen from B. pseudomallei

December 22nd, 2014 by Davide Gaudesi, Claudio Peri, Giacomo Quilici, Alessandro Gori, Mario Ferrer-Navarro, Oscar Conchillo-Solé, Rachael Thomas, Arnone Nithichanon, Ganjana Lertmemongkolchai, Richard Titball, Xavier Daura, Giorgio Colombo and Giovanna Musco

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ACS Chemical Biology
DOI: 10.1021/cb500831y