Structure-Guided Design of a High Affinity Inhibitor to Human CtBP

January 30th, 2015 by Brendan J. Hilbert, Benjamin L. Morris, Keith C. Ellis, Janet L. Paulsen, Celia A. Schiffer, Steven R. Grossman and William E. Royer

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ACS Chemical Biology
DOI: 10.1021/cb500820b

Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites

January 30th, 2015 by I. J. Frame, Roman Deniskin, Alison Rinderspacher, Francine Katz, Shi-Xian Deng, Robyn D. Moir, Sophie H. Adjalley, Olivia Coburn-Flynn, David A. Fidock, Ian M. Willis, Donald W. Landry and Myles H. Akabas

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ACS Chemical Biology
DOI: 10.1021/cb500981y
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Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance

January 30th, 2015 by Mackenzie D. Martin, Laurent Calcul, Courtney Smith, Umesh K. Jinwal, Sarah N. Fontaine, April Darling, Kent Seeley, Lukasz Wojtas, Malathi Narayan, Jason E. Gestwicki, Garry R. Smith, Allen B. Reitz, Bill J. Baker and Chad A. Dickey

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ACS Chemical Biology
DOI: 10.1021/cb501013w
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Genetically Enhanced Lysozyme Evades a Pathogen Derived Inhibitory Protein

January 30th, 2015 by Sarah M. Dostal, Yongliang Fang, Jonathan C. Guerrette, Thomas C. Scanlon and Karl E. Griswold

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ACS Chemical Biology
DOI: 10.1021/cb500976y

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

January 29th, 2015 by Erik C. Hett, Hua Xu, Kieran F. Geoghegan, Ariamala Gopalsamy, Robert E. Kyne, Carol A. Menard, Arjun Narayanan, Mihir D. Parikh, Shenping Liu, Lee Roberts, Ralph P. Robinson, Michael A. Tones and Lyn H. Jones

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ACS Chemical Biology
DOI: 10.1021/cb5009475

C5-Epimerase and 2-O-Sulfotransferase Associate in Vitro to Generate Contiguous Epimerized and 2-O-Sulfated Heparan Sulfate Domains

January 28th, 2015 by Aurélie Préchoux, Célia Halimi, Jean-Pierre Simorre, Hugues Lortat-Jacob and Cédric Laguri

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ACS Chemical Biology
DOI: 10.1021/cb501037a
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Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

January 28th, 2015 by Yao Zhang, René Bartz, Gevorg Grigoryan, Michael Bryant, Jeff Aaronson, Stephen Beck, Nathalie Innocent, Lee Klein, William Procopio, Tom Tucker, Vasant Jadhav, David M. Tellers and William F. DeGrado

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ACS Chemical Biology
DOI: 10.1021/cb500759p
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Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1

January 28th, 2015 by Michael T. Perfetti, Brandi M. Baughman, Bradley M. Dickson, Yunxiang Mu, Gaofeng Cui, Pavel Mader, Aiping Dong, Jacqueline L. Norris, Scott B. Rothbart, Brian D. Strahl, Peter J. Brown, William P. Janzen, Cheryl H. Arrowsmith, Georges Mer, Kevin M.

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ACS Chemical Biology
DOI: 10.1021/cb500956g
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Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion

January 27th, 2015 by Daliang Li, Lin Liu and Wen-Hong Li

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ACS Chemical Biology
DOI: 10.1021/cb5007536
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Small Molecule Inhibitors of Disulfide Bond Formation by the Bacterial DsbA–DsbB Dual Enzyme System

January 27th, 2015 by Maria A. Halili, Prabhakar Bachu, Fredrik Lindahl, Chérine Bechara, Biswaranjan Mohanty, Robert C. Reid, Martin J. Scanlon, Carol V. Robinson, David P. Fairlie and Jennifer L. Martin

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ACS Chemical Biology
DOI: 10.1021/cb500988r
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