Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

February 4th, 2015 by Brittany L. Howard, Katherine L. Harvey, Rebecca J. Stewart, Mauro F. Azevedo, Brendan S. Crabb, Ian G. Jennings, Paul R. Sanders, David T. Manallack, Philip E. Thompson, Christopher J. Tonkin and Paul R. Gilson

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ACS Chemical Biology
DOI: 10.1021/cb501004q
  • Posted in ACS Chemical Biology, Publications
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Isofunctional Enzymes PAD1 and UbiX Catalyze Formation of a Novel Cofactor Required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-polyprenylbenzoic Acid Decarboxylase

February 3rd, 2015 by Fengming Lin, Kyle L. Ferguson, David R. Boyer, Xiaoxia Nina Lin and E. Neil G. Marsh

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ACS Chemical Biology
DOI: 10.1021/cb5008103
  • Posted in ACS Chemical Biology, Publications
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Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg5

February 3rd, 2015 by Hideshi Yokoyama, Jun-ichi Sawada, Shiori Katoh, Kenji Matsuno, Naohisa Ogo, Yoshinobu Ishikawa, Hiroshi Hashimoto, Satoshi Fujii and Akira Asai

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ACS Chemical Biology
DOI: 10.1021/cb500939x

Structural Basis of a Temporin 1b Analogue Antimicrobial Activity against Gram Negative Bacteria Determined by CD and NMR Techniques in Cellular Environment

January 30th, 2015 by Gaetano Malgieri, Concetta Avitabile, Maddalena Palmieri, Luca Domenico D’Andrea, Carla Isernia, Alessandra Romanelli and Roberto Fattorusso

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ACS Chemical Biology
DOI: 10.1021/cb501057d
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Structure-Guided Design of a High Affinity Inhibitor to Human CtBP

January 30th, 2015 by Brendan J. Hilbert, Benjamin L. Morris, Keith C. Ellis, Janet L. Paulsen, Celia A. Schiffer, Steven R. Grossman and William E. Royer

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ACS Chemical Biology
DOI: 10.1021/cb500820b

Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites

January 30th, 2015 by I. J. Frame, Roman Deniskin, Alison Rinderspacher, Francine Katz, Shi-Xian Deng, Robyn D. Moir, Sophie H. Adjalley, Olivia Coburn-Flynn, David A. Fidock, Ian M. Willis, Donald W. Landry and Myles H. Akabas

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ACS Chemical Biology
DOI: 10.1021/cb500981y
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Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance

January 30th, 2015 by Mackenzie D. Martin, Laurent Calcul, Courtney Smith, Umesh K. Jinwal, Sarah N. Fontaine, April Darling, Kent Seeley, Lukasz Wojtas, Malathi Narayan, Jason E. Gestwicki, Garry R. Smith, Allen B. Reitz, Bill J. Baker and Chad A. Dickey

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ACS Chemical Biology
DOI: 10.1021/cb501013w
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Genetically Enhanced Lysozyme Evades a Pathogen Derived Inhibitory Protein

January 30th, 2015 by Sarah M. Dostal, Yongliang Fang, Jonathan C. Guerrette, Thomas C. Scanlon and Karl E. Griswold

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ACS Chemical Biology
DOI: 10.1021/cb500976y

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

January 29th, 2015 by Erik C. Hett, Hua Xu, Kieran F. Geoghegan, Ariamala Gopalsamy, Robert E. Kyne, Carol A. Menard, Arjun Narayanan, Mihir D. Parikh, Shenping Liu, Lee Roberts, Ralph P. Robinson, Michael A. Tones and Lyn H. Jones

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ACS Chemical Biology
DOI: 10.1021/cb5009475

C5-Epimerase and 2-O-Sulfotransferase Associate in Vitro to Generate Contiguous Epimerized and 2-O-Sulfated Heparan Sulfate Domains

January 28th, 2015 by Aurélie Préchoux, Célia Halimi, Jean-Pierre Simorre, Hugues Lortat-Jacob and Cédric Laguri

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ACS Chemical Biology
DOI: 10.1021/cb501037a
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