A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation

April 15th, 2015 by Alison Ribeiro, Silvia Pontis, Luisa Mengatto, Andrea Armirotti, Valerio Chiurchiù, Valeria Capurro, Annalisa Fiasella, Andrea Nuzzi, Elisa Romeo, Guillermo Moreno-Sanz, Mauro Maccarrone, Angelo Reggiani, Giorgio Tarzia, Marco Mor, Fabio Bertozzi, T

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00114
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A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism

April 6th, 2015 by Tejia Zhang, Loren D. Walensky and Alan Saghatelian

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00168

Large-Scale Metabolomics Reveals a Complex Response of Aspergillus nidulans to Epigenetic Perturbation

April 2nd, 2015 by Jessica C. Albright, Matthew T. Henke, Alexandra A. Soukup, Ryan A. McClure, Regan J. Thomson, Nancy P. Keller and Neil L. Kelleher

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00025
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A Simple Method for GFP- and RFP-based Dual Color Single-Molecule Localization Microscopy

April 1st, 2015 by Evgenia Platonova, Christian M. Winterflood and Helge Ewers

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00046

Exquisitely Specific Bisubstrate Inhibitors of c-Src Kinase

March 31st, 2015 by Kristoffer R. Brandvold, Shana M. Santos, Meghan E. Breen, Eric J. Lachacz, Michael E. Steffey and Matthew B. Soellner

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ACS Chemical Biology
DOI: 10.1021/cb501048b

Hydrocarbon Stapled Peptides as Modulators of Biological Function

March 31st, 2015 by Philipp M. Cromm, Jochen Spiegel and Tom N. Grossmann

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ACS Chemical Biology
DOI: 10.1021/cb501020r

A New Class of Orthosteric uPAR·uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR·Vitronectin Interaction

March 31st, 2015 by Degang Liu, Donghui Zhou, Bo Wang, William Eric Knabe and Samy O. Meroueh

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ACS Chemical Biology
DOI: 10.1021/cb500832q
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Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

March 30th, 2015 by Megha Bajaj, Sreeman K. Mamidyala, Johannes Zuegg, Stephanie L. Begg, Miranda P. Ween, Zhenyao Luo, Johnny X. Huang, Alastair G. McEwan, Bostjan Kobe, James C. Paton, Christopher A. McDevitt and Matthew A. Cooper

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ACS Chemical Biology
DOI: 10.1021/cb501032x
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PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes

March 25th, 2015 by Yuxiao Wang, Tienhuei G. Ho, Eugen Franz, Jennifer S. Hermann, F. Donelson Smith, Heidi Hehnly, Jessica L. Esseltine, Laura E. Hanold, Mandi M. Murph, Daniela Bertinetti, John D. Scott, Friedrich W. Herberg and Eileen J. Kennedy

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00009

Observing Lysozyme’s Closing and Opening Motions by High-Resolution Single-Molecule Enzymology

March 20th, 2015 by Maxim V. Akhterov, Yongki Choi, Tivoli J. Olsen, Patrick C. Sims, Mariam Iftikhar, O. Tolga Gul, Brad L. Corso, Gregory A. Weiss and Philip G. Collins

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ACS Chemical Biology
DOI: 10.1021/cb500750v