Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

March 30th, 2015 by Megha Bajaj, Sreeman K. Mamidyala, Johannes Zuegg, Stephanie L. Begg, Miranda P. Ween, Zhenyao Luo, Johnny X. Huang, Alastair G. McEwan, Bostjan Kobe, James C. Paton, Christopher A. McDevitt and Matthew A. Cooper

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb501032x
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes

March 25th, 2015 by Yuxiao Wang, Tienhuei G. Ho, Eugen Franz, Jennifer S. Hermann, F. Donelson Smith, Heidi Hehnly, Jessica L. Esseltine, Laura E. Hanold, Mandi M. Murph, Daniela Bertinetti, John D. Scott, Friedrich W. Herberg and Eileen J. Kennedy

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00009

Observing Lysozyme’s Closing and Opening Motions by High-Resolution Single-Molecule Enzymology

March 20th, 2015 by Maxim V. Akhterov, Yongki Choi, Tivoli J. Olsen, Patrick C. Sims, Mariam Iftikhar, O. Tolga Gul, Brad L. Corso, Gregory A. Weiss and Philip G. Collins

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500750v

A Small Molecule That Inhibits OGT Activity in Cells

March 18th, 2015 by Rodrigo F. Ortiz-Meoz, Jiaoyang Jiang, Michael B. Lazarus, Marina Orman, John Janetzko, Chenguang Fan, Damien Y. Duveau, Zhi-Wei Tan, Craig J. Thomas and Suzanne Walker

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00004

Constructing de Novo H2O2 Signaling via Induced Protein Proximity

March 18th, 2015 by Guihua Zeng, Roushu Zhang, Weimin Xuan, Wei Wang and Fu-Sen Liang

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00170

Optochemical Dissection of T-box Gene-Dependent Medial Floor Plate Development

March 17th, 2015 by Alexander Y. Payumo, Whitney J. Walker, Lindsey E. McQuade, Sayumi Yamazoe and James K. Chen

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5010178

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

March 17th, 2015 by Xiaoqing Wu, Lan Lan, David Michael Wilson, Rebecca T. Marquez, Wei-chung Tsao, Philip Gao, Anuradha Roy, Benjamin Andrew Turner, Peter McDonald, Jon A Tunge, Steven A Rogers, Dan A. Dixon, Jeffrey Aubé and Liang Xu

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500851u

Chemoenzymatically Prepared Heparan Sulfate Containing Rare 2-O-Sulfonated Glucuronic Acid Residues

March 17th, 2015 by Rio S. Boothello, Aurijit Sarkar, Vy My Tran, Thao Kim Nu Nguyen, Nehru Viji Sankaranarayanan, Akul Y. Mehta, AlHumaidi Alabbas, Spencer Brown, Alessandro Rossi, April C. Joice, Caitlin P. Mencio, Maritza V. Quintero, Balagurunathan Kuberan and Umesh

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00071
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Chemoenzymatically Prepared Heparan Sulfate Containing Rare 2-O-Sulfonated Glucuronic Acid Residues

Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

March 16th, 2015 by Hyun Lee, Hao Lei, Bernard D. Santarsiero, Joseph L. Gatuz, Shuyi Cao, Amy J. Rice, Kavankumar Patel, Michael Z. Szypulinski, Isabel Ojeda, Arun K. Ghosh and Michael E. Johnson

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500917m
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N6-methyladenosine Recognition

March 16th, 2015 by Hyun Seok Jeong, Gosuke Hayashi and Akimitsu Okamoto

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb5010096
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N6-methyladenosine Recognition