Rutaecarpine Analogues Reduce Lipid Accumulation in Adipocytes via Inhibiting Adipogenesis/Lipogenesis with AMPK Activation and UPR Suppression

April 23rd, 2015 by Ying-Chun Chen, Xiao-Yi Zeng, Yan He, Hong Liu, Bin Wang, Han Zhou, Jian-Wen Chen, Pei-Qing Liu, Lian-Quan Gu, Ji-Ming Ye and Zhi-Shu Huang

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00242
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Membrane Curvature Affects the Formation of α-Hemolysin Nanopores

April 22nd, 2015 by Satoshi Fujii, Tomoaki Matsuura and Tetsuya Yomo

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00107

Covalent Molecular Probes for Class A G Protein-Coupled Receptors: Advances and Applications

April 22nd, 2015 by Dietmar Weichert and Peter Gmeiner

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00070

Substrate-Controlled Stereochemistry in Natural Product Biosynthesis

April 20th, 2015 by Wei Ding, Yongzhen Li and Qi Zhang

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00104

A Genetically Encoded FRET Sensor for Intracellular Heme

April 17th, 2015 by Yanqun Song, Maiyun Yang, Seraphine V. Wegner, Jingyi Zhao, Rongfeng Zhu, Yun Wu, Chuan He and Peng R. Chen

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ACS Chemical Biology
DOI: 10.1021/cb5009734

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells

April 17th, 2015 by Daniel I. Benjamin, Daniel S. Li, Wallace Lowe, Timothy Heuer, George Kemble and Daniel K. Nomura

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00240
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Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism

April 16th, 2015 by Dahabada H. J. Lopes, Aida Attar, Gayatri Nair, Eric Hayden, Zhenming Du, Kirsten McDaniel, Som Dutt, Kenny Bravo-Rodriguez, Sumit Mittal, Frank-Gerrit Klärner, Chunyu Wang, Elsa Sanchez-Garcia, Thomas Schrader and Gal Bitan

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00146

Distinct Metal Isoforms Underlie Promiscuous Activity Profiles of Metalloenzymes

April 15th, 2015 by Florian Baier, John Chen, Matthew Solomonson, Natalie C.J. Strynadka and Nobuhiko Tokuriki

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00068

Orthogonal Thiol Functionalization at a Single Atomic Center for Profiling Transthiolation Activity of E1 Activating Enzymes

April 15th, 2015 by Mathew Stanley, Cong Han, Axel Knebel, Paul Murphy, Natalia Shpiro and Satpal Virdee

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00118
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A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation

April 15th, 2015 by Alison Ribeiro, Silvia Pontis, Luisa Mengatto, Andrea Armirotti, Valerio Chiurchiù, Valeria Capurro, Annalisa Fiasella, Andrea Nuzzi, Elisa Romeo, Guillermo Moreno-Sanz, Mauro Maccarrone, Angelo Reggiani, Giorgio Tarzia, Marco Mor, Fabio Bertozzi, T

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00114
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