Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism

April 16th, 2015 by Dahabada H. J. Lopes, Aida Attar, Gayatri Nair, Eric Hayden, Zhenming Du, Kirsten McDaniel, Som Dutt, Kenny Bravo-Rodriguez, Sumit Mittal, Frank-Gerrit Klärner, Chunyu Wang, Elsa Sanchez-Garcia, Thomas Schrader and Gal Bitan

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00146

Distinct Metal Isoforms Underlie Promiscuous Activity Profiles of Metalloenzymes

April 15th, 2015 by Florian Baier, John Chen, Matthew Solomonson, Natalie C.J. Strynadka and Nobuhiko Tokuriki

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00068

Orthogonal Thiol Functionalization at a Single Atomic Center for Profiling Transthiolation Activity of E1 Activating Enzymes

April 15th, 2015 by Mathew Stanley, Cong Han, Axel Knebel, Paul Murphy, Natalia Shpiro and Satpal Virdee

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00118
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A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation

April 15th, 2015 by Alison Ribeiro, Silvia Pontis, Luisa Mengatto, Andrea Armirotti, Valerio Chiurchiù, Valeria Capurro, Annalisa Fiasella, Andrea Nuzzi, Elisa Romeo, Guillermo Moreno-Sanz, Mauro Maccarrone, Angelo Reggiani, Giorgio Tarzia, Marco Mor, Fabio Bertozzi, T

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00114
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A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism

April 6th, 2015 by Tejia Zhang, Loren D. Walensky and Alan Saghatelian

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00168

Large-Scale Metabolomics Reveals a Complex Response of Aspergillus nidulans to Epigenetic Perturbation

April 2nd, 2015 by Jessica C. Albright, Matthew T. Henke, Alexandra A. Soukup, Ryan A. McClure, Regan J. Thomson, Nancy P. Keller and Neil L. Kelleher

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00025
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A Simple Method for GFP- and RFP-based Dual Color Single-Molecule Localization Microscopy

April 1st, 2015 by Evgenia Platonova, Christian M. Winterflood and Helge Ewers

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00046

Exquisitely Specific Bisubstrate Inhibitors of c-Src Kinase

March 31st, 2015 by Kristoffer R. Brandvold, Shana M. Santos, Meghan E. Breen, Eric J. Lachacz, Michael E. Steffey and Matthew B. Soellner

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ACS Chemical Biology
DOI: 10.1021/cb501048b

Hydrocarbon Stapled Peptides as Modulators of Biological Function

March 31st, 2015 by Philipp M. Cromm, Jochen Spiegel and Tom N. Grossmann

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ACS Chemical Biology
DOI: 10.1021/cb501020r

A New Class of Orthosteric uPAR·uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR·Vitronectin Interaction

March 31st, 2015 by Degang Liu, Donghui Zhou, Bo Wang, William Eric Knabe and Samy O. Meroueh

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ACS Chemical Biology
DOI: 10.1021/cb500832q
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