Sparsomycin Biosynthesis Highlights Unusual Module Architecture and Processing Mechanism in Non-ribosomal Peptide Synthetase

June 9th, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00284
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Sparsomycin Biosynthesis Highlights Unusual Module Architecture and Processing Mechanism in Non-ribosomal Peptide Synthetase

Withaferin A Analogs That Target the AAA+ Chaperone p97

June 3rd, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00367

Metabolic dynamics analysis by massive data integration: application to tsunami-affected field soils in Japan

June 2nd, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/cb500609p
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Metabolic dynamics analysis by massive data integration: application to tsunami-affected field soils in Japan

Multivalent Antigens for Promoting B and T Cell Activation

June 2nd, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00239

Targeting the Early Step of Building Block Organization in Viral Capsid Assembly

May 29th, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00347

A Clickable Aminooxy Probe for Monitoring Cellular ADP-Ribosylation

May 27th, 2015 by Rory K. Morgan and Michael S. Cohen

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00213

What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein–Protein Interface of the tRNA-Modifying Enzyme Tgt

May 26th, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00028
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein–Protein Interface of the tRNA-Modifying Enzyme Tgt

Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53

May 22nd, 2015 by Alex M. Chapman and Brian R. McNaughton

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00201
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy

May 22nd, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00101
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes

May 22nd, 2015 by

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.5b00304
  • Posted in ACS Chemical Biology, Publications
  • Comments Off on Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes