Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53

May 22nd, 2015 by Alex M. Chapman and Brian R. McNaughton

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00201
  • Posted in ACS Chemical Biology, Publications
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Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy

May 22nd, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00101
  • Posted in ACS Chemical Biology, Publications
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Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes

May 22nd, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00304
  • Posted in ACS Chemical Biology, Publications
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A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation

May 19th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00103

A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin

May 18th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00226
  • Posted in ACS Chemical Biology, Publications
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Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids

May 15th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00119
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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

May 15th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00245

A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2α Complex Structures

May 15th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00235
  • Posted in ACS Chemical Biology, Publications
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Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein–Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint

May 15th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/acschembio.5b00121
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A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member

May 15th, 2015 by

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ACS Chemical Biology
DOI: 10.1021/cb501046t
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