Understanding the Molecular Mechanisms of the CRISPR Toolbox Using Single Molecule Approaches

February 9th, 2018 by Digvijay Singh and Taekjip Ha

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00905

Development of Activity-Based Chemical Probes for Human Sirtuins

February 8th, 2018 by Elysian Graham, Stacia Rymarchyk, Marci Wood and Yana Cen

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00754

Toward a Microparticle-Based System for Pooled Assays of Small Molecules in Cellular Contexts

February 8th, 2018 by Carrie E. Yozwiak, Tal Hirschhorn and Brent R. Stockwell

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00043

Identifying Novel Enhancer Elements with CRISPR-Based Screens

January 10th, 2018 by Jason C. Klein, Wei Chen, Molly Gasperini and Jay Shendure

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00778

Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors

January 4th, 2018 by Ganglin Wang, Zhi Li and Nan Ma

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00887

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017Utility and Limitations

December 26th, 2017 by Jonathan B. Baell and J. Willem M. Nissink

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00903

Fluorescent Probes of DNA Repair

November 30th, 2017 by David L. Wilson and Eric T. Kool

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00919

Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

November 30th, 2017 by Myung-Ryul Lee, Namrata Raman, Samuel H. Gellman, David M. Lynn and Sean P. Palecek

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00843
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Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing

November 14th, 2017 by Danielle N. Gallagher and James E. Haber

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00760

Large Scale Mutational and Kinetic Analysis of a Self-Hydrolyzing Deoxyribozyme

November 3rd, 2017 by V. Dhamodharan, Shungo Kobori and Yohei Yokobayashi

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00621