Mechanism of Drug–Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer

March 25th, 2015 by Ilia G. Denisov, Yelena V. Grinkova, Javier L. Baylon, Emad Tajkhorshid and Stephen G. Sligar

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Biochemistry
DOI: 10.1021/acs.biochem.5b00079

Probing the Molecular Architecture of Arabidopsis thaliana Secondary Cell Walls Using Two- and Three-Dimensional 13C Solid State Nuclear Magnetic Resonance Spectroscopy

March 25th, 2015 by Ray Dupree, Thomas J. Simmons, Jennifer C. Mortimer, Dharmesh Patel, Dinu Iuga, Steven P. Brown and Paul Dupree

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Biochemistry
DOI: 10.1021/bi501552k

DNA Adenine Methyltransferase Facilitated Diffusion Is Enhanced by Protein–DNA “Roadblock” Complexes That Induce DNA Looping

March 25th, 2015 by Adam J. Pollak and Norbert O. Reich

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Biochemistry
DOI: 10.1021/bi501344r

Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly

March 24th, 2015 by Latesh Lad, Sheila Clancy, David Koditek, Melanie H. Wong, Debi Jin, Anita Niedziela-Majka, Giuseppe A. Papalia, Magdeleine Hung, Stephen Yant, John R. Somoza, Eric Hu, Chienhung Chou, Winston Tse, Randall Halcomb, Roman Sakowicz and Nikos Pagratis

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Biochemistry
DOI: 10.1021/acs.biochem.5b00151

Biophysical Comparison of Soluble Amyloid-β(1–42) Protofibrils, Oligomers, and Protofilaments

March 24th, 2015 by Michael R. Nichols, Benjamin A. Colvin, Elizabeth A. Hood, Geeta S. Paranjape, David C. Osborn and Shana E. Terrill-Usery

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Biochemistry
DOI: 10.1021/bi500957g

Self-Assembly of a Nine-Residue Amyloid-Forming Peptide Fragment of SARS Corona Virus E-Protein: Mechanism of Self Aggregation and Amyloid-Inhibition of hIAPP

March 24th, 2015 by Anirban Ghosh, Amit S. Pithadia, Jyotsna Bhat, Supriyo Bera, Anupam Midya, Carol A. Fierke, Ayyalusamy Ramamoorthy and Anirban Bhunia

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Biochemistry
DOI: 10.1021/acs.biochem.5b00061

Redox Potential Tuning through Differential Quinone Binding in the Photosynthetic Reaction Center of Rhodobacter sphaeroides

March 23rd, 2015 by Josh V. Vermaas, Alexander T. Taguchi, Sergei A. Dikanov, Colin A. Wraight and Emad Tajkhorshid

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Biochemistry
DOI: 10.1021/acs.biochem.5b00033

Inverse Thio Effects in the Hepatitis Delta Virus Ribozyme Reveal that the Reaction Pathway Is Controlled by Metal Ion Charge Density

March 23rd, 2015 by Pallavi Thaplyal, Abir Ganguly, Sharon Hammes-Schiffer and Philip C. Bevilacqua

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Biochemistry
DOI: 10.1021/acs.biochem.5b00190

Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8

March 20th, 2015 by Christophe Decroos, Dane J. Clausen, Brandon E. Haines, Olaf Wiest, Robert M. Williams and David W. Christianson

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Biochemistry
DOI: 10.1021/acs.biochem.5b00010

Molecular Determinants of Polyubiquitin Recognition by Continuous Ubiquitin-Binding Domains of Rad18

March 19th, 2015 by Trung Thanh Thach, Namsoo Lee, Donghyuk Shin, Seungsu Han, Gyuhee Kim, Hongtae Kim and Sangho Lee

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Biochemistry
DOI: 10.1021/bi5012546