[ASAP] The Burden Borne by Protein Methyltransferases: Rates and Equilibria of Non-enzymatic Methylation of Amino Acid Side Chains by SAM in Water

March 5th, 2021 by Charles A. Lewis, Jr. and Richard Wolfenden

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.1c00028

Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

March 4th, 2021 by Liguo Wang

Nature Chemical Biology, Published online: 04 March 2021; doi:10.1038/s41589-021-00742-5

A selective and potent CDK2 degrader was developed that induced differentiation of acute myeloid leukemia cell lines and primary patient cells.
  • Posted in Nat Chem Biol, Publications
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Mutanofactin promotes adhesion and biofilm formation of cariogenic <i>Streptococcus mutans</i>

March 4th, 2021 by Zhong-Rui Li

Nature Chemical Biology, Published online: 04 March 2021; doi:10.1038/s41589-021-00745-2

The mutanofactin family of lipopeptide natural products, produced by strains of cariogenic Streptococcus mutans, promotes biofilm formation via increased cell-surface hydrophobicity and binding to extracellular DNA.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism

March 4th, 2021 by Melanie L. Johnston and Caren L. Freel Meyers

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.1c00019

[ASAP] Structural Perturbations of Exon-Skipping Edits within the Dystrophin D20:24 Region

March 3rd, 2021 by Xin Niu and Nick Menhart

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Biochemistry
DOI: 10.1021/acs.biochem.0c00827

Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

March 2nd, 2021 by Yilong Zou

Nature Chemical Biology, Published online: 02 March 2021; doi:10.1038/s41589-021-00767-w

Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
  • Posted in Nat Chem Biol, Publications
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Orphan receptor GPR37L1 remains unliganded

March 1st, 2021 by Tony Ngo

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00748-z

Orphan receptor GPR37L1 remains unliganded

Binding site for activator MDL-801 on SIRT6

March 1st, 2021 by Weijie You

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00749-y

Binding site for activator MDL-801 on SIRT6

Reply to: Binding site for MDL-801 on SIRT6

March 1st, 2021 by Zhimin Huang

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00750-5

Reply to: Binding site for MDL-801 on SIRT6

Oncohistones: corruption at the core

March 1st, 2021 by Kanishk Jain

Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00764-z

High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.