Mucin tuning

July 26th, 2021 by Philip Lössl

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00849-9

Mucin tuning

Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

July 26th, 2021 by Wei Jiang

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00836-0

A survey of natural metabolic pathways for C1 substrates (methane, methanol, carbon dioxide, and carbon monoxide) highlights past efforts and recent progress, and informs future opportunities to create synthetic C1-utilizing microbes.
  • Posted in Nat Chem Biol, Publications
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Prospecting for natural products by genome mining and microcrystal electron diffraction

July 26th, 2021 by Lee Joon Kim

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00834-2

Combined use of microcrystal electron diffraction and genome mining for biosynthetic gene clusters enables the rapid structural elucidation of natural products, including a newly discovered 2-pyridone compound and a revised structure of fischerin.
  • Posted in Nat Chem Biol, Publications
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Untying knots with force

July 26th, 2021 by Pan T. X. Li

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00856-w

RNA knot-like structures function as an efficient physical barrier to RNA exoribonucleases. Single-molecule mechanical manipulation is used to unfold these structures and unravel the cause of their unusual mechanical resistance from a different direction.

Central dogma, redefined

July 26th, 2021 by Yiyun Song

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00850-2

Central dogma, redefined

A molecular shape-shifter

July 26th, 2021 by Karin Kühnel

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00848-w

A molecular shape-shifter

Picking off persisters

July 26th, 2021 by Caitlin Deane

Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00847-x

Picking off persisters

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

July 22nd, 2021 by Daniel B. Grabarczyk

Nature Chemical Biology, Published online: 22 July 2021; doi:10.1038/s41589-021-00831-5

The full-length structure of HUWE1 reveals the bipartite organization of a giant E3 ubiquitin ligase, comprising a catalytic HECT domain and a large, ring-shaped scaffold that provides docking sites for various substrates and regulates E3 activity.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences

July 21st, 2021 by Zhe Feng, Bowen Jia, and Mingjie Zhang

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.1c00376

[ASAP] Correlated Motions in Structural Biology

July 21st, 2021 by Da Xu, Steve P. Meisburger, and Nozomi Ando

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.1c00420