[ASAP] <italic toggle=”yes”>In Silico</italic> Protein Design Promotes the Rapid Evolution of Industrial Enzymes

September 20th, 2018 by Yang Wang, Jian Chen, Zhen Kang

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00896

[ASAP] Caught in the Act? Quantifying Biochemistry Inside and Outside of Biomolecular Condensates

September 20th, 2018 by Johannes H. Wilbertz, Jeffrey A. Chao

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00905

[ASAP] Interactions of the DNA Repair Enzyme Human Thymine DNA Glycosylase with Cognate and Noncognate DNA

September 19th, 2018 by Natalia Kanaan, Petra Imhof

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00409

[ASAP] Enhancing Light-Driven 1,3-Propanediol Production by Using Natural Compartmentalization of Differentiated Cells

September 19th, 2018 by Hongyu Liu, Jun Ni, Ping Xu, Fei Tao

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00239
  • Posted in ACS Synthetic Biology, Publications
  • Comments Off on [ASAP] Enhancing Light-Driven 1,3-Propanediol Production by Using Natural Compartmentalization of Differentiated Cells

[ASAP] New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

September 18th, 2018 by Edwin R. Ragwan, Eri Arai, Yan Kung

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00869

Flipping out the peptide

September 17th, 2018 by Stephanie Gras

Flipping out the peptide

Flipping out the peptide, Published online: 17 September 2018; doi:10.1038/s41589-018-0133-1

T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.

Diversifying bases

September 17th, 2018 by Yiyun Song

Diversifying bases

Diversifying bases, Published online: 17 September 2018; doi:10.1038/s41589-018-0141-1

Diversifying bases

A new target for thalidomide

September 17th, 2018 by Peter G. Wells

A new target for thalidomide

A new target for thalidomide, Published online: 17 September 2018; doi:10.1038/s41589-018-0134-0

One mechanism of thalidomide teratogenicity involves binding to the CUL4–CRBN E3 ubiquitin ligase complex, which then mediates the degradation of transcription factors. New studies reveal that species-specific variants of the transcription factor SALL4 are differentially ubiquitinated and degraded via the thalidomide-bound complex.

Cost–benefit analysis

September 17th, 2018 by Grant Miura

Cost–benefit analysis

Cost–benefit analysis, Published online: 17 September 2018; doi:10.1038/s41589-018-0139-8

Cost–benefit analysis

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

September 17th, 2018 by Timothy P. Riley

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability, Published online: 17 September 2018; doi:10.1038/s41589-018-0130-4

Structural analysis shows that cross-reactivity of the T cell receptor DMF5 is governed by adaptability of the peptide antigen, which can undergo TCR-binding-induced frameshifting forcing the peptide C terminus to extend from the MHC-binding groove.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability