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Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries by Martin Hintersteiner, Larry Gerace, Manfred Auer and colleagues. ACS Chem. Biol., 2010, 5 (10), pp 967–979. In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors.
Ribozymes and Riboswitches: Modulation of RNA Function by Small Molecules by Jinwei Zhang, Matthew W. Lau, Adrian R. Ferré-D’Amaré. Biochemistry 2010 49 (43), 9123-9131. Diverse small molecules interact with catalytic RNAs (ribozymes) as substrates and cofactors, and their intracellular concentrations are sensed by gene-regulatory mRNA domains (riboswitches) that modulate transcription, splicing, translation, or RNA stability.